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March 7, 1964, Vol 187, No. 10 >
MULTIPLE DISCIPLINE RESEARCH FORUM | March 7, 1964

Evaluation of Reticuloendothelial Function in Man

Nathan K. Salky, MD; Nicholas R. Di Luzio, PhD; David B. P' Pool, MD; Arthur J. Sutherland, MD
[+] Author Affiliations

Read before the session on immune processes and microbiology of the Third Multiple Discipline Research Forum during the 112th Annual Meeting of the American Medical Association, Atlantic City, NJ, June 20, 1963.


Memphis

From the departments of physiology and medicine, University of Tennessee Medical Units.


JAMA. 1964;187(10):744-748. doi:10.1001/jama.1964.03060230072019
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References

The CONCEPT of the reticuloendothelial system (RES) as groups of fixed macrophages in various organs which are related functionally and morphologically was developed by Aschoff in 1924.1 Since that time, experimental studies have amply documented the involvement of the RES in areas of lipid metabolism, tumor growth, antibody production, and general host resistance,2 but lack of a practical method of measuring RE function in man has hindered an accurate estimation of its clinical significance.

In experimental studies, colloidal substances which are known to be phagocytized by RE cells and whose rate of disappearance from the circulation can be measured, such as colloidal gold or carbon, are employed to evaluate RE function. Since these colloids are not metabolized, they cannot be safely administered to human subjects in doses large enough to determine RE phagocytic activity or capacity. Recently, I131-labeled aggregated albumin has been developed for the clinical

REFERENCES

1 +
Aschoff, L.:  Das reticulo-endothelial System , Ergebn Inn Med Kinderheilk 26:1, 1924;.
2 +
Heller, J.H., ed: Reticulo-Endothelial Structure and Function , New York: Ronald Press Co., 1960;.
3 +
Iio, M., and Wagner, H.N., Jr.:  Studies of Reticulo-Endothelial System (RES): I. Measurement of Phagocytic Capacity of RES in Man and Dog , J Clin Invest 42:417, 1963;.
4 +
Di Luzio, N.R., and Riggi, S.J.: " Hepatic Participation in Chylomicron Metabolism ," in Triglyceride Metabolism , F. Kruger and G. Cowgill, ed., Springfield, Ill: Charles C Thomas, to be published.
5 +
Riggi, S.J., and Di Luzio, N.R.:  Removal of Chylomicra and Fat Emulsion by Reticulo-Endothelial System (RES): New Functional Test for RE Activity , Fed Proc 21:279, 1962;.
6 +
Ashworth, C.T.; Riggi, S.J.; and Di Luzio, N.R.:  Morphologic Study of Effect of Reticulo-Endothelial (RE) Stimulation Upon Hepatic Removal of Minute Particles From Blood of Rats , Exp Molec Path 1:83, 1963;.
7 +
Ladman, A.J.; Salky, N.K.; and Di Luzio, N.R.:  Electron Microscopic Observations of Human Liver After Intravenous Administration of Reticulo-Endothelial (RE ) Test Lipid Emulsion , J Appl Physics 34:2504, 1963;.
8 +
Storer, E.H.:  Fat Emulsions for Clinical Intravenous Therapy , Arch Surg (Chicago) 80:214, 1960;.
9 +
Feinberg, L.J., et al:  Disappearance Curves of Intravenously Administered I131-Triolein in Human Subjects , Amer J Cardiol 8:1, 1961;.
10 +
Zilversmit, D.B., et al:  Preparation and Use of Anhydrous Fat Emulsions for Intravenous Feeding and Metabolic Experiments , J Lab Clin Med 48:386, 1956;.
11 +
Van Handel, E., and Zilversmit, D.B.:  Micromethod for Direct Determination of Serum Triglyceride , J Lab Clin Med 50:152, 1957;.
12 +
Riggi, S.J., and Di Luzio, N.R.:  Influence of Reticulo-Endothelial Stimulation on Response of Rats to Dietary Cholesterol , J Lipid Res 3:339, 1962;.
13 +
Dole, V.P.:  Relation Between Non-Esterified Fatty Acids in Plasma and Metabolism of Glucose , J Clin Invest 35:150, 1956;.
14 +
Dixon, W.J., and Massey, F.J.: Introduction to Statistical Analysis , New York: McCraw-Hill Book Co, Inc, 1957;.
15 +
Benacerraf, B.G., et al: " Physiology of Phagocytosis of Particles by RES ," Physiopathology of Reticulo-Endothelial Systems: Symposium . Oxford: Blackwell Scientific Publications, 1957;, p 52.
16 +
Wagner, H.N., Jr.; Iio, M.; and Hornick, R.B.:  Studies of Reticulo-Endothelial System: II. Changes in Phagocytic Capacity of RES in Patients With Certain Infections , J Clin Invest 42:427, 1963;.
17 +
Day, A.J., and Gould-Hurst, P.R.S.:  Esterification of C14 Labeled Cholesterol by Reticulo-Endothelial Cells , Quart J Exp Physiol 46:376, 1961;.
18 +
Wooles, W.A., and Di Luzio, N.R.:  Reticulo-Endothelial Function and Immune Response , Science 142:1078, 1963;.

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1 +
Aschoff, L.:  Das reticulo-endothelial System , Ergebn Inn Med Kinderheilk 26:1, 1924;.
2 +
Heller, J.H., ed: Reticulo-Endothelial Structure and Function , New York: Ronald Press Co., 1960;.
3 +
Iio, M., and Wagner, H.N., Jr.:  Studies of Reticulo-Endothelial System (RES): I. Measurement of Phagocytic Capacity of RES in Man and Dog , J Clin Invest 42:417, 1963;.
4 +
Di Luzio, N.R., and Riggi, S.J.: " Hepatic Participation in Chylomicron Metabolism ," in Triglyceride Metabolism , F. Kruger and G. Cowgill, ed., Springfield, Ill: Charles C Thomas, to be published.
5 +
Riggi, S.J., and Di Luzio, N.R.:  Removal of Chylomicra and Fat Emulsion by Reticulo-Endothelial System (RES): New Functional Test for RE Activity , Fed Proc 21:279, 1962;.
6 +
Ashworth, C.T.; Riggi, S.J.; and Di Luzio, N.R.:  Morphologic Study of Effect of Reticulo-Endothelial (RE) Stimulation Upon Hepatic Removal of Minute Particles From Blood of Rats , Exp Molec Path 1:83, 1963;.
7 +
Ladman, A.J.; Salky, N.K.; and Di Luzio, N.R.:  Electron Microscopic Observations of Human Liver After Intravenous Administration of Reticulo-Endothelial (RE ) Test Lipid Emulsion , J Appl Physics 34:2504, 1963;.
8 +
Storer, E.H.:  Fat Emulsions for Clinical Intravenous Therapy , Arch Surg (Chicago) 80:214, 1960;.
9 +
Feinberg, L.J., et al:  Disappearance Curves of Intravenously Administered I131-Triolein in Human Subjects , Amer J Cardiol 8:1, 1961;.
10 +
Zilversmit, D.B., et al:  Preparation and Use of Anhydrous Fat Emulsions for Intravenous Feeding and Metabolic Experiments , J Lab Clin Med 48:386, 1956;.
11 +
Van Handel, E., and Zilversmit, D.B.:  Micromethod for Direct Determination of Serum Triglyceride , J Lab Clin Med 50:152, 1957;.
12 +
Riggi, S.J., and Di Luzio, N.R.:  Influence of Reticulo-Endothelial Stimulation on Response of Rats to Dietary Cholesterol , J Lipid Res 3:339, 1962;.
13 +
Dole, V.P.:  Relation Between Non-Esterified Fatty Acids in Plasma and Metabolism of Glucose , J Clin Invest 35:150, 1956;.
14 +
Dixon, W.J., and Massey, F.J.: Introduction to Statistical Analysis , New York: McCraw-Hill Book Co, Inc, 1957;.
15 +
Benacerraf, B.G., et al: " Physiology of Phagocytosis of Particles by RES ," Physiopathology of Reticulo-Endothelial Systems: Symposium . Oxford: Blackwell Scientific Publications, 1957;, p 52.
16 +
Wagner, H.N., Jr.; Iio, M.; and Hornick, R.B.:  Studies of Reticulo-Endothelial System: II. Changes in Phagocytic Capacity of RES in Patients With Certain Infections , J Clin Invest 42:427, 1963;.
17 +
Day, A.J., and Gould-Hurst, P.R.S.:  Esterification of C14 Labeled Cholesterol by Reticulo-Endothelial Cells , Quart J Exp Physiol 46:376, 1961;.
18 +
Wooles, W.A., and Di Luzio, N.R.:  Reticulo-Endothelial Function and Immune Response , Science 142:1078, 1963;.

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