Thrombotic Thrombocytopenic Purpura in Pregnancy FREE

Walter Solomon, MD; Daniel S. Turner, MD; Charles Block, MD; A. Charles Posner, MD

[+] Author Affiliations

New York

From the departments of laboratories, medicine, and obstetrics, the Bronx Hospital.; Dr. Block is a Fellow of the National Heart Institute, National Institutes of Health.

JAMA. 1963;184(7):587-590. doi:10.1001/jama.1963.73700200008025a

Text Size: A A A

Published online

Article

References

ABSTRACT

ABSTRACT | REFERENCES

THROMBOTIC THROMBOCYTOPENIC PURPURA (TTP) is being diagnosed with increasing frequency. Five cases have been reported in which the disease occurred as a complication of pregnancy.^1-4 We are here presenting a synopsis of these cases and are adding a sixth case together with a discussion of diagnosis and management.

Report of a Case On Jan 20, 1961, a 28-yr-old pregnant woman, Gravida 6, Para 4, whose expected date of confinement was Feb 20, came to The Bronx Hospital in active labor. Fifteen minutes after admission a 4 lb 6 oz (2.0 kg) girl was delivered spontaneously. Intrapartum bleeding was estimated at less than 150 cc. The only notable signs at this time were pallor (Table 1) and a blood pressure of 140/90 mm Hg. A blood transfusion had to be discontinued after 800 cc because of a chill and vomiting. Rectal temperature was 100 F (37.8 C) and pulse rate

REFERENCES

ABSTRACT | REFERENCES

Miner, P. F.; Nutt, R. L.; and Thomas, M. E.: Thrombotic Thrombocytopenic Purpura Occurring in Pregnancy , Amer J Obstet Gynec 70:611-617, 1955;.

Reisfield, D. R.: Thrombotic Thrombocytopenic Purpura and Pregnancy , Obstet Gynec Survey 14:303-321, 1959;.

O'Leary, J. A., and Marchetti, A. A.: Thrombotic Thrombocytopenic Purpura in Pregnancy , Amer J Obstet Gynec 83:214-219, 1962;.

Reisfield, D. R.: Death from Thrombotic Thrombocytopenic Purpura During Pregnancy , Obstet Gynec 19:517-520, 1962;.

Singer, K.; Motulsky, A. G.; and Shanberge, J. N.: Thrombotic Thrombocytopenic Purpura II: Studies on Hemolytic Syndrome in Disease , Blood 5:434-448, 1950;.

Lukes, R. J., et al: Thrombotic Thrombocytopenic Purpura—Clinical and Pathological Findings in 49 Cases, Abstracted , Blood 17:366, 1961;.

Brain, M. C.; Dacie, J. V.; and Hourihane, D. O'B.: Microangiopathic Haemolytic Anaemia: Possible Role of Vascular Lesions in Pathogenesis , Brit J Haemat 8:358-374, 1962;.

Rubinstein, M. A., et al: Unusual Remission in Case of Thrombotic Thrombocytopenic Purpura Syndrome Following Fresh Blood Exchange Transfusions , Ann Intern Med 51:1409-1419, 1959;.

Pritchard, J. A.; Ratnoff, O. D.; and Weissman, R., Jr.: Hemostatic Defects and Increased Red Cell Destruction in Preeclampsia and Eclampsia , Obstet Gynec 4:159-164, 1954;.

Ruffolo, E. H.; Pease, G. L.; and Cooper, T.: Thrombotic Thrombocytopenic Purpura; Antemortem Diagnosis: Use of Paraffin Sections of Sternal Bone-marrow Aspirate , Arch Intern Med (Chicago) 110:78-82, 1962;.

Hill, J. M., and Loeb, E.: Massive Hormonal Therapy and Splenectomy in Acute Thrombotic Thrombocytopenic Purpura: Report of Three Cases with One Eight-Year Cure , JAMA 173:778-783, 1960;.

McElin, T. W.; Mussey, R. D.; and Watkins, C. H.: Splenectomy During Pregnancy, with Report of 5 Cases and Review of Literature , Amer J Obstet Gynec 59:1036-1044, 1950;.

First Page Preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal