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September 15, 1962, Vol 181, No. 11 >
ARTICLE | September 15, 1962

Clinical Science FREE

[+] Author Affiliations

From the Biophysics Research Laboratory of the Division of Medical Biology, Department of Medicine, Harvard Medical School, and the Peter Bent Brigham Hospital.

Assistant Professor of Medicine, Harvard Medical School, Senior Associate in Medicine, Peter Bent Brigham Hospital, and investigator, Howard Hughes Medical Institute (Dr. Wacker). Research Fellow in Surgery (urology), Harvard Medical School, Assistant in Surgery (urology), Peter Bent Brigham Hospital, and recipient of F.N.G. Starr Memorial Scholarship, University of Toronto. On leave of absence from Department of Surgery, University of Toronto (Dr. Dorfman).


JAMA. 1962;181(11):972-978. doi:10.1001/jama.1962.03050370040009
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References

Urinary Lactic Dehydrogenase Activity  I. Screening Method for Detection of Cancer of Kidneys and BladderWarren E. C. Wacker, M.D., and Lionel E. Dorfman, M.D., BostonLACTIC DEHYDROGENASE ACTIVITY (LDH) X has been reported to be present in urine,1-3 but its presence has not previously been utilized in diagnosis. LDH activity in serum and other body fluids, such as pleural effusions and ascitic fluid, however, has been used widely in the diagnosis of a large number of diseases including acute myocardial infarction,4,5 pulmonary embolism,6,8 and cancer.7,8 The present study demonstrates that an increased LDH activity in urine provides a potent diagnostic screening method for detection of malignant tumors of the kidneys and bladder.The present successful development of an adequate method for measurement of LDH activity in urine depended upon recognition and elimination of substances that inhibit LDH activity and that have been found in all

REFERENCES

1 +
Pojer, J.; Mojiz, A.; and Tovarek, J.:  Activité enzymatique de l'urine au cours des nephropathies , Rev Franc Etud Clin Biol 5:919-921 ( (Sept.) ) 1960;.
2 +
Rosalki, S. B., and Wilkinson, J. H.:  Urinary Lactic Dehydrogenase in Renal Disease , Lancet 2:327-328 ( (Sept. 12) ) 1959;.
3 +
Crockson, R. A.:  Lactic Dehydrogenase in Renal Diseases; Urinary Concentrations and Relative Clearances , Lancet 1:140-142 ( (Jan. 12) ) 1961;.
4 +
Snodgrass, P. J., et al.:  Metalloenzymes and Myocardial Infarction. III. Lactic Dehydrogenase Activity of Serum. Determinate Diagnostic Measure , New Engl J Med 261:1258-1266 ( (Dec. 17) ) 1959;.
5 +
Wacker, W. E. C.; Ulmer, D. D.; and Valle, B. L.:  Metalloenzymes and Myocardial Infarction. II. Malic and Lactic Dehydrogenase Activities and Zinc Concentrations in Serum , New Engl J Med 255:449-456 ( (Sept. 6) ) 1956;.
6 +
Wacker, W. E. C., et al.:  Triad for Diagnosis of Pulmonary Embolism , JAMA 178:8-13 ( (Oct. 7) ) 1961;.
7 +
Hill, B. R., and Levi, C.:  Elevation of Serum Component in Neoplastic Disease , Cancer Res 14:513-515, 1954;.
8 +
Wroblewski, F.:  Significance of Alterations in Lactic Dehydrogenase Activity of Body Fluids in Diagnosis of Malignant Tumors , Cancer 12:27-39 ( (Feb.) ) 1959;.
9 +
Dorfman, L. E., and Amador, E.: Assay of Urinary Lactic Dehydrogenase Activity, unpublished data.
10 +
Dorfman, L. E. and Wacker, W. E. C.: Urinary Lactic Dehydrogenase Activity. II. Its Clinical Usefulness in Diagnosis and Prognosis of Diseases of Kidneys, unpublished data.
11 +
Papanicolaou, G. N., and Traut, H. F.: Diagnosis of Uterine Cancer by Vaginal Smear , New York: Commonwealth Fund, 1943;.
12 +
Stevenson, C. S., et al.:  Changing Picture of Cervical Carcinoma , JAMA 179:92-96 ( (March 24) ) 1962;.
13 +
Francis, R. R.:  Carcinoma of Bladder , J Urol 85:552-555 ( (April) ) 1961;.
14 +
Lucke, B., and Schlumberger, H. G.:  Tumors of Kidney, Renal Pelvis and Ureter , in Atlas of Tumor Pathology, Section VIII , Fascicle (30) , Armed Forces Institute of Pathology, 1957;.
15 +
Amador, E.; Dorfman, L. E.; and Wacker, W. E. C.: Serum LDH Activity. Analytical Assessment of Current Assays, unpublished data.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Pojer, J.; Mojiz, A.; and Tovarek, J.:  Activité enzymatique de l'urine au cours des nephropathies , Rev Franc Etud Clin Biol 5:919-921 ( (Sept.) ) 1960;.
2 +
Rosalki, S. B., and Wilkinson, J. H.:  Urinary Lactic Dehydrogenase in Renal Disease , Lancet 2:327-328 ( (Sept. 12) ) 1959;.
3 +
Crockson, R. A.:  Lactic Dehydrogenase in Renal Diseases; Urinary Concentrations and Relative Clearances , Lancet 1:140-142 ( (Jan. 12) ) 1961;.
4 +
Snodgrass, P. J., et al.:  Metalloenzymes and Myocardial Infarction. III. Lactic Dehydrogenase Activity of Serum. Determinate Diagnostic Measure , New Engl J Med 261:1258-1266 ( (Dec. 17) ) 1959;.
5 +
Wacker, W. E. C.; Ulmer, D. D.; and Valle, B. L.:  Metalloenzymes and Myocardial Infarction. II. Malic and Lactic Dehydrogenase Activities and Zinc Concentrations in Serum , New Engl J Med 255:449-456 ( (Sept. 6) ) 1956;.
6 +
Wacker, W. E. C., et al.:  Triad for Diagnosis of Pulmonary Embolism , JAMA 178:8-13 ( (Oct. 7) ) 1961;.
7 +
Hill, B. R., and Levi, C.:  Elevation of Serum Component in Neoplastic Disease , Cancer Res 14:513-515, 1954;.
8 +
Wroblewski, F.:  Significance of Alterations in Lactic Dehydrogenase Activity of Body Fluids in Diagnosis of Malignant Tumors , Cancer 12:27-39 ( (Feb.) ) 1959;.
9 +
Dorfman, L. E., and Amador, E.: Assay of Urinary Lactic Dehydrogenase Activity, unpublished data.
10 +
Dorfman, L. E. and Wacker, W. E. C.: Urinary Lactic Dehydrogenase Activity. II. Its Clinical Usefulness in Diagnosis and Prognosis of Diseases of Kidneys, unpublished data.
11 +
Papanicolaou, G. N., and Traut, H. F.: Diagnosis of Uterine Cancer by Vaginal Smear , New York: Commonwealth Fund, 1943;.
12 +
Stevenson, C. S., et al.:  Changing Picture of Cervical Carcinoma , JAMA 179:92-96 ( (March 24) ) 1962;.
13 +
Francis, R. R.:  Carcinoma of Bladder , J Urol 85:552-555 ( (April) ) 1961;.
14 +
Lucke, B., and Schlumberger, H. G.:  Tumors of Kidney, Renal Pelvis and Ureter , in Atlas of Tumor Pathology, Section VIII , Fascicle (30) , Armed Forces Institute of Pathology, 1957;.
15 +
Amador, E.; Dorfman, L. E.; and Wacker, W. E. C.: Serum LDH Activity. Analytical Assessment of Current Assays, unpublished data.

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