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January 20, 1962, Vol 179, No. 3 >
Other Articles | January 20, 1962

Thymic Tumor and Erythroblastic Aplasia

C. William H. Havard, D.M., M.R.C.P.; J. Anthony Parrish, M.B., M.R.C.P.
[+] Author Affiliations

London, England


JAMA. 1962;179(3):228-230. doi:10.1001/jama.1962.03050030042012b
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References

THE ASSOCIATION of a thymic tumor with selective aplasia of erythrocytes has aroused considerable interest over the last decade. Our knowledge of the syndrome has recently been reviewed. One of the curious features of this association is that erythroblastic aplasia may follow some years after the removal of a symptomless thymic tumor, although this has only been reported on 2 occasions. We feel that the following case is worthy of note, as it provides a further instance of this latent interval. Furthermore, remission of erythropoietic failure was achieved by splenectomy and steroid therapy, although neither treatment had been effective by itself.

Report of a Case

A 53-year-old woman with dyspepsia was examined in December, 1954. There were no physical signs of disease and no evidence of myasthenia, nor was there anemia (hemoglobin 14.5 gm/100 ml.). A radiograph of the chest showed a smooth, lobulated tumor in the anterior mediastinum. A

REFERENCES

1 +
Bayrd, E. D., and Bernatz, P. E.:  Benign Thymoma and Agenesis of Erythrocytes , JAMA 163:723-727 ( (March 2) ) 1957;.
2 +
Chalmers, J. N. M., and Boheimer, K.: Brit Med J 2:1514, 1954;.
3 +
Clarkson, B., and Prockop, D. J.:  Aregenerative Anemia Associated with Benign Thymoma , New Engl J Med 259:253-258 ( (Aug. 7) ) 1958;.
4 +
Ehrenreich, T., and Allen, A. C.:  Myasthenia Gravis Following Extirpation of Asymptomatic Thymoma , Cancer 11:173-180 ( (Jan.) -Feb.) 1958;.
5 +
Gray, H. K.:  In Thymic Neoplasms by D. B. Effler, and L. J. McCormick , J Thorac Surg 31:79( (Jan.) ) 1956;.
6 +
Havard, C. W. H., and Scott, R. B.:  Thymic Tumour and Erythroblastic Aplasia , Brit J Haemat 6:178-190 ( (April) ) 1960;.
7 +
Hodgkinson, R.:  Blood Dyscrasias Associated with Chloramphenicol; Investigation into Cases in British Isles , Lancet 1:285-287 ( (Feb. 6) ) 1954;.
8 +
Humphreys, G. H., and Southwood, H.: Amer J Med Sci 210:501, 1945;.
9 +
Jacobs, E. M., et al.:  Benign Thymoma and Selective Erythroid Aplasia of Bone Marrow , Cancer 12:47-57 ( (Jan.) -Feb.) 1959;.
10 +
Lambie, A. T.; Burrows, B. A.; and Sommers, S. C.:  Clinicopathologic Conference, Refractory Anemia, Agammaglobulinemia, and Mediastinal Tumor , Amer J Clin Path 27:444-452 ( (April) ) 1957;.
11 +
Lewis, C. N., et al.:  Chloramphenicol (Chloromycetin) in Relation to Blood Dyscrasias with Observations on Other Drugs; Special Survey , Antibiot Chemother 2:601-609 ( (Dec.) ) 1952;.
12 +
Loeb, V., Jr.;  Diagnostic Problems: Comment , JAMA 160:1319( (April 14) ) 1956;.
13 +
Ozer, F. L.; Truax, W. E.; and Levin, W. C.:  Erythyroid Hypoplasia Associated with Chloramphenicol Therapy , Blood 16:997-1001 ( (July) ) 1960;.
14 +
Ramos, A. J.:  Diagnostic Problems: Presentation of Case , JAMA 160:1317-1319 ( (April 14) ) 1956;.
15 +
Rheingold, J. J., and Spurling, C. L.:  Chloramphenicol and Aplastic Anemia , JAMA 149:1301-1304 ( (Aug. 2) ) 1952;.
16 +
Ross, J. F., et al.:  Simultaneous Occurrence of Benign Thymoma and Refractory Anemia , Blood 9:935-952 ( (Oct.) ) 1954;.
17 +
Shaw, R. G., and McLean, J. A.:  Chloramphenicol and Aplastic Anaemia , Med J Australia 1:352-359 ( (March 16) ) 1957;.

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1 +
Bayrd, E. D., and Bernatz, P. E.:  Benign Thymoma and Agenesis of Erythrocytes , JAMA 163:723-727 ( (March 2) ) 1957;.
2 +
Chalmers, J. N. M., and Boheimer, K.: Brit Med J 2:1514, 1954;.
3 +
Clarkson, B., and Prockop, D. J.:  Aregenerative Anemia Associated with Benign Thymoma , New Engl J Med 259:253-258 ( (Aug. 7) ) 1958;.
4 +
Ehrenreich, T., and Allen, A. C.:  Myasthenia Gravis Following Extirpation of Asymptomatic Thymoma , Cancer 11:173-180 ( (Jan.) -Feb.) 1958;.
5 +
Gray, H. K.:  In Thymic Neoplasms by D. B. Effler, and L. J. McCormick , J Thorac Surg 31:79( (Jan.) ) 1956;.
6 +
Havard, C. W. H., and Scott, R. B.:  Thymic Tumour and Erythroblastic Aplasia , Brit J Haemat 6:178-190 ( (April) ) 1960;.
7 +
Hodgkinson, R.:  Blood Dyscrasias Associated with Chloramphenicol; Investigation into Cases in British Isles , Lancet 1:285-287 ( (Feb. 6) ) 1954;.
8 +
Humphreys, G. H., and Southwood, H.: Amer J Med Sci 210:501, 1945;.
9 +
Jacobs, E. M., et al.:  Benign Thymoma and Selective Erythroid Aplasia of Bone Marrow , Cancer 12:47-57 ( (Jan.) -Feb.) 1959;.
10 +
Lambie, A. T.; Burrows, B. A.; and Sommers, S. C.:  Clinicopathologic Conference, Refractory Anemia, Agammaglobulinemia, and Mediastinal Tumor , Amer J Clin Path 27:444-452 ( (April) ) 1957;.
11 +
Lewis, C. N., et al.:  Chloramphenicol (Chloromycetin) in Relation to Blood Dyscrasias with Observations on Other Drugs; Special Survey , Antibiot Chemother 2:601-609 ( (Dec.) ) 1952;.
12 +
Loeb, V., Jr.;  Diagnostic Problems: Comment , JAMA 160:1319( (April 14) ) 1956;.
13 +
Ozer, F. L.; Truax, W. E.; and Levin, W. C.:  Erythyroid Hypoplasia Associated with Chloramphenicol Therapy , Blood 16:997-1001 ( (July) ) 1960;.
14 +
Ramos, A. J.:  Diagnostic Problems: Presentation of Case , JAMA 160:1317-1319 ( (April 14) ) 1956;.
15 +
Rheingold, J. J., and Spurling, C. L.:  Chloramphenicol and Aplastic Anemia , JAMA 149:1301-1304 ( (Aug. 2) ) 1952;.
16 +
Ross, J. F., et al.:  Simultaneous Occurrence of Benign Thymoma and Refractory Anemia , Blood 9:935-952 ( (Oct.) ) 1954;.
17 +
Shaw, R. G., and McLean, J. A.:  Chloramphenicol and Aplastic Anaemia , Med J Australia 1:352-359 ( (March 16) ) 1957;.

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