New York City
From the Department of Pathology, The Mount Sinai Hospital.
THE INDUCTION of hepatocellular carcinoma is not dependent on continuous feeding of carcinogen. Short periods of exposure to carcinogen may result in tumors many weeks or months after drug withdrawal.1 Nevertheless, hepatocellular injury and hyperplasia apparently precede the development of hepatomas. The persistence, regression, or alteration of early hepatocellular injury and hyperplasia were studied in rats after withdrawal of 3'-methyl-4-dimethylamino azobenzene (methyl butter yellow, MeBY), a potent carcinogen. Since 26 days of drug feeding causes a low incidence of hepatocellular carcinoma and 40 days a high incidence of hepatomas,2 2 groups of rats fed the drug for these intervals were compared. Morphologic changes that were more prominent in the second group might be associated with hepatoma induction. The formation and persistence of nodules of hydropic, weakly basophilic cells, deficient in glucose-6-phosphatase (G-6-P' ase) that are closely associated with hepatocellular carcinoma will be described.
Materials and Methods Sprague-Dawley male
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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