A case of severe insulin reaction resulting in unconsciousness of 60 hours' duration was caused in a young diabetic woman by the erroneous administration of 1,800 units of insulin. Early recognition of the hypoglycemia and intensive treatment were responsible for the patient's complete recovery.
The patient, a 16-year-old, overweight girl, was brought to the emergency room on Jan. 3, 1956, after having been unconscious for the preceding three hours. This was her 14th hospital admission. She had been a known diabetic since 1948, taking about 100 units of insulin daily. Her previous admissions had been primarily for diabetic acidosis and coma, of which she had a total of 11 episodes in 1955 alone. The patient was dehydrated and restless and responded little to external stimuli. Her face was flushed, temperature was 100.0 F (37.7 C), and pulse rate was 120 per minute. She did not have Kussmaul's respiration. The urine