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INSULIN REACTION AND RECOVERY IN DIABETIC PATIENT: Title and subTitle BreakREPORT OF A CASE FREE

Marios C. Balodimos, M.D.; Hae Sok Kim, M.D.
[+] Author Affiliations

Jacksonville, Fla.

From St. Vincent's Hospital.


JAMA. 1960;173(13):1476-1478. doi:10.1001/jama.1960.73020310001018
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A case of severe insulin reaction resulting in unconsciousness of 60 hours' duration was caused in a young diabetic woman by the erroneous administration of 1,800 units of insulin. Early recognition of the hypoglycemia and intensive treatment were responsible for the patient's complete recovery.

The patient, a 16-year-old, overweight girl, was brought to the emergency room on Jan. 3, 1956, after having been unconscious for the preceding three hours. This was her 14th hospital admission. She had been a known diabetic since 1948, taking about 100 units of insulin daily. Her previous admissions had been primarily for diabetic acidosis and coma, of which she had a total of 11 episodes in 1955 alone. The patient was dehydrated and restless and responded little to external stimuli. Her face was flushed, temperature was 100.0 F (37.7 C), and pulse rate was 120 per minute. She did not have Kussmaul's respiration. The urine

REFERENCES

Warren, S., and Le Compte, P. M.: Pathology of Diabetes Mellitus , ed. 3, Philadelphia, Lea & Febiger, 1952;, p. 243.
Baker, A. B.:  Cerebral Damage in Hypoglycemia: Review , Am. J. Psychiat. 96:109-127 ( (July) ) 1939;.
Jones, G. M.:  Posthypoglycemic Encephalopathy: Case Reports , Am. J. M. Sc. 213:206-213 ( (Feb.) ) 1947;.
Anderson, E. W.:  Psychiatric Complications of Hypoglycemia in Children , Lancet 2:329-331 ( (Sept. 14) ) 1940;.
Allan, F. N., and Crommelin, R. M.:  Cerebral Damage from Insulin "Shock": Hemiplegia, Asphasia and Epileptic Seizures for 15 Months , J. A. M. A. 118:373-374 ( (Jan. 31) ) 1942;.
Gardner, L. I., and Reyersbach, G. C.:  Brain Damage in Juvenile Diabetic Associated with Insulin Hypoglycemia , Pediatrics 7:210-214 ( (Feb.) ) 1951;.
Joslin, E. P.; Root, H. F.; White, P.; and Marble, A.: Treatment of Diabetes Mellitus , ed. 10, Philadelphia, Lea & Febiger, 1959;, p. 319.
Räihä, C. E.:  Eine mehrere Tage dauernde Funktionsstörung des Grosshirns infolgeeschwerer Hypoglykämie , Acta paediat. 18:315-321 ( (March 16) ) 1936;.
Vogl, A., and Youngwirth, S. H.:  Effects of Single Dose of 2,000 Units of Protamine Zinc Insulin Taken by Diabetic Patient with Suicidal Intent , New England J. Med. 241:606-609 ( (Oct. 20) ) 1949;.

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Warren, S., and Le Compte, P. M.: Pathology of Diabetes Mellitus , ed. 3, Philadelphia, Lea & Febiger, 1952;, p. 243.
Baker, A. B.:  Cerebral Damage in Hypoglycemia: Review , Am. J. Psychiat. 96:109-127 ( (July) ) 1939;.
Jones, G. M.:  Posthypoglycemic Encephalopathy: Case Reports , Am. J. M. Sc. 213:206-213 ( (Feb.) ) 1947;.
Anderson, E. W.:  Psychiatric Complications of Hypoglycemia in Children , Lancet 2:329-331 ( (Sept. 14) ) 1940;.
Allan, F. N., and Crommelin, R. M.:  Cerebral Damage from Insulin "Shock": Hemiplegia, Asphasia and Epileptic Seizures for 15 Months , J. A. M. A. 118:373-374 ( (Jan. 31) ) 1942;.
Gardner, L. I., and Reyersbach, G. C.:  Brain Damage in Juvenile Diabetic Associated with Insulin Hypoglycemia , Pediatrics 7:210-214 ( (Feb.) ) 1951;.
Joslin, E. P.; Root, H. F.; White, P.; and Marble, A.: Treatment of Diabetes Mellitus , ed. 10, Philadelphia, Lea & Febiger, 1959;, p. 319.
Räihä, C. E.:  Eine mehrere Tage dauernde Funktionsstörung des Grosshirns infolgeeschwerer Hypoglykämie , Acta paediat. 18:315-321 ( (March 16) ) 1936;.
Vogl, A., and Youngwirth, S. H.:  Effects of Single Dose of 2,000 Units of Protamine Zinc Insulin Taken by Diabetic Patient with Suicidal Intent , New England J. Med. 241:606-609 ( (Oct. 20) ) 1949;.
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