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PSEUDO-PSEUDOHYPOPARATHYROIDISM: Title and subTitle BreakREPORT OF A CASE WITH ASSOCIATED CARDIOPULMONARY SYNDROME OF OBESITY FREE

Thomas R. Casey, M.D.; Bernhard B. Fast, M.D.; Reuben M. Cherniack, M.D.
[+] Author Affiliations

Winnipeg, Manitoba, Canada

From the Department of Medicine, University of Manitoba, and the Clinical Investigation Unit, Department of Medicine, Winnipeg General Hospital. Dr. Chemiack is a Markle scholar in medical science.


JAMA. 1959;169(17):1988-1990. doi:10.1001/jama.1959.03000340020005
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The term pseudo-pseudohypoparathyroidism is applied to a condition in which a patient with dyschondroplasia and ectopic bone formation responds to administration of parathyroid hormone. The patient here described, a 61-year-old woman, had a round facies, short stature, shortened metacarpals and metatarsals, symmetrical deformities of both elbows, and lens opacities. Her response to parathyroid hormone was not studied, but determinations of calcium and phosphorus in her blood suggested normal parathyroid function. Hospitalization was made necessary by excessive drowsiness associated with alveolar hypoventilation and obesity. The patient left the hospital much improved after achieving a weight-reduction of 9 kg. (20 lb.).

REFERENCES

Albright, F.; Burnett, C. H.; Smith, P. H.; and Parson, W.:  Pseudo-Hypoparathyroidism—Example of "Seabright-Bantam Syndrome": Report of 3 Cases , Endocrinology 30:922-932 ( (June) ) 1942;.
Albright, F.; Forbes, A. P.; and Henneman, P. H.:  Pseudo-Pseudohypoparathyroidism , Tr. A. Am. Physicians 65:337-350, 1952;.
Austen, F. K.; Carmichael, M. W.; and Adams, R. D.:  Neurologic Manifestations of Chronic Pulmonary Insufficiency , New England J. Med. 257:579-590 ( (Sept. 26) ) 1957;.
Sieker, H. O.; Estes, E. H., Jr.; Kelser, G. A.; and McIntosh, H. D.:  Cardiopulmonary Syndrome Associated with Extreme Obesity , abstracted, J. Clin. Invest. 34:916 ( (June) ) 1955;.
Auchincloss, J. H., Jr.; Cook, E.; and Renzetti, A. D.:  Clinical and Physiological Aspects of Case of Obesity, Polycythemia and Alveolar Hypoventilation , J. Clin. Invest. 34:1537-1545 ( (Oct.) ) 1955;.
Weil, M. H.:  Polycythemia Associated with Obesity , J. A. M. A. 159:1592-1595 ( (Dec. 24) ) 1955;.
Carroll, D.:  Peculiar Type of Cardiopulmonary Failure Associated with Obesity , Am. J. Med. 21:819-824 ( (Nov.) ) 1956;.
Burwell, C. S.; Robin, E. D.; Whaley, R. D.; and Bicklemann, A. G.:  Extreme Obesity Associated with Alveolar Hypoventilation—Pickwickian Syndrome , Am. J. Med. 21: 811-818 ( (Nov.) ) 1956;.
Lillington, G. A.; Anderson, M. W.; and Brandenburg, R. O.:  Cardiorespiratory Syndrome of Obesity , Dis. Chest 32:1-20 ( (July) ) 1957;.
Kaufman, B. J.; Ferguson, M. H.; and Cherniack, R. M.:  Hypoventilation in Obesity , J. Clin. Invest. , to be published.
Miles, J., and Elrick, H.:  Pseudo-Pseudohypoparathyroidism: Report of New Case , J. Clin. Endocrinol. 15: 576-584 ( (May) ) 1955;.
Roche, M.:  Case of Pseudo-Pseudohypoparathyroidism , J. Clin. Endocrinol. 15:964-969 ( (Aug.) ) 1955;.
Wallach, S.; Englert, E.; and Brown, H.:  Syndrome of Pseudo-Pseudohypoparathyroidism , A. M. A. Arch. Int. Med. 98:517-524 ( (Oct.) ) 1956;.
McNeely, E. G.; Raisz, L. G.; and Lemay, M.:  Dyschondroplasia with Soft Tissue Calcification and Ossification, and Normal Parathyroid Function ("Pseudo-Pseudohypoparathyroidism") , Am. J. Med. 21:649-656 ( (Oct.) ) 1956;.
Seringe, P. H., and Tomkiewicz, S.:  Familial Pseudo-Pseudohypoparathyroidism , Ann. Endocrinol. 17:655-664 ( (Oct.) ) 1956;.
Cusmano, J. V.; Baker, D. H.; and Finbey, N.:  Pseudohypoparathyroidism , Radiology 07:845-853 ( (Dec.) ) 1956;.

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Albright, F.; Burnett, C. H.; Smith, P. H.; and Parson, W.:  Pseudo-Hypoparathyroidism—Example of "Seabright-Bantam Syndrome": Report of 3 Cases , Endocrinology 30:922-932 ( (June) ) 1942;.
Albright, F.; Forbes, A. P.; and Henneman, P. H.:  Pseudo-Pseudohypoparathyroidism , Tr. A. Am. Physicians 65:337-350, 1952;.
Austen, F. K.; Carmichael, M. W.; and Adams, R. D.:  Neurologic Manifestations of Chronic Pulmonary Insufficiency , New England J. Med. 257:579-590 ( (Sept. 26) ) 1957;.
Sieker, H. O.; Estes, E. H., Jr.; Kelser, G. A.; and McIntosh, H. D.:  Cardiopulmonary Syndrome Associated with Extreme Obesity , abstracted, J. Clin. Invest. 34:916 ( (June) ) 1955;.
Auchincloss, J. H., Jr.; Cook, E.; and Renzetti, A. D.:  Clinical and Physiological Aspects of Case of Obesity, Polycythemia and Alveolar Hypoventilation , J. Clin. Invest. 34:1537-1545 ( (Oct.) ) 1955;.
Weil, M. H.:  Polycythemia Associated with Obesity , J. A. M. A. 159:1592-1595 ( (Dec. 24) ) 1955;.
Carroll, D.:  Peculiar Type of Cardiopulmonary Failure Associated with Obesity , Am. J. Med. 21:819-824 ( (Nov.) ) 1956;.
Burwell, C. S.; Robin, E. D.; Whaley, R. D.; and Bicklemann, A. G.:  Extreme Obesity Associated with Alveolar Hypoventilation—Pickwickian Syndrome , Am. J. Med. 21: 811-818 ( (Nov.) ) 1956;.
Lillington, G. A.; Anderson, M. W.; and Brandenburg, R. O.:  Cardiorespiratory Syndrome of Obesity , Dis. Chest 32:1-20 ( (July) ) 1957;.
Kaufman, B. J.; Ferguson, M. H.; and Cherniack, R. M.:  Hypoventilation in Obesity , J. Clin. Invest. , to be published.
Miles, J., and Elrick, H.:  Pseudo-Pseudohypoparathyroidism: Report of New Case , J. Clin. Endocrinol. 15: 576-584 ( (May) ) 1955;.
Roche, M.:  Case of Pseudo-Pseudohypoparathyroidism , J. Clin. Endocrinol. 15:964-969 ( (Aug.) ) 1955;.
Wallach, S.; Englert, E.; and Brown, H.:  Syndrome of Pseudo-Pseudohypoparathyroidism , A. M. A. Arch. Int. Med. 98:517-524 ( (Oct.) ) 1956;.
McNeely, E. G.; Raisz, L. G.; and Lemay, M.:  Dyschondroplasia with Soft Tissue Calcification and Ossification, and Normal Parathyroid Function ("Pseudo-Pseudohypoparathyroidism") , Am. J. Med. 21:649-656 ( (Oct.) ) 1956;.
Seringe, P. H., and Tomkiewicz, S.:  Familial Pseudo-Pseudohypoparathyroidism , Ann. Endocrinol. 17:655-664 ( (Oct.) ) 1956;.
Cusmano, J. V.; Baker, D. H.; and Finbey, N.:  Pseudohypoparathyroidism , Radiology 07:845-853 ( (Dec.) ) 1956;.
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