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SERUM LACTIC DEHYDROGENASE—A DIAGNOSTIC AID IN MYOCARDIAL INFARCTION FREE

Roderick P. MacDonald, Ph.D.; John R. Simpson, M.D.; Egon Nossal, B.S.
[+] Author Affiliations

Detroit

From the departments of pathology and internal medicine, Harper Hospital.


JAMA. 1957;165(1):35-40. doi:10.1001/jama.1957.02980190037009
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The usefulness of specific enzyme reactions to clinical medicine is becoming increasingly more apparent. Patients suffering destruction of various tissue cells have increased enzymatic activity in their serum. The enzymes normally present within the cells are liberated into the blood stream as cell destruction occurs. The determination of serum lactic dehydrogenase (LDH) as an aid in the diagnosis of acute myocardial infarction has two advantages: first the increased elevation is present for as long as six to eight days after attack; second, the technical procedure is far less complicated than other enzyme tests. LDH determination, not ordinarily necessary in the diagnosis of acute myocardial infarction, is particularly helpful when the electrocardiograph pattern masks the recent changes of an acute infarction.

REFERENCES

Karmen, A.; Wróblewski, F.; and LaDue, J. S.:  Transaminase Activity in Human Blood , J. Clin. Invest. 34:126-133 ( (Jan.) ) 1955;.
Wróblewski, F., and LaDue, J. S.:  Lactic Dehydrogenase Activity in Blood , Proc. Soc. Exper. Biol. & Med. 90: 210-213 ( (Oct.) ) 1955;.
Wróblewski, F.; Ruegsegger, P., and LaDue, J. S.:  Serum Lactic Dehydrogenase Activity in Acute Transmural Myocardial Infarction , Science 123:1122-1123 ( (June 22) ) 1956;.
Hill, B. R., and Levi, C.:  Elevation of Serum Component in Neoplastic Disease , Cancer Res. 14:513-515 ( (Aug.) ) 1954;.
Hsieh, K. M., and Blumenthal, H. T.:  Serum Lactic Dehydrogenase Levels in Various Disease States , Proc. Soc. Exper. Biol. & Med. 91:626-630 ( (April) ) 1956;.
White, L. P.:  Serum Enzymes: Serum Lactic Dehydrogenase in Myocardial Infarction , New England J. Med. 255:984-988 ( (Nov. 22) ) 1956;.
Wacker, W. E. C.; Ulmer, D. D.; and Vallee, B. L.:  Malic and Lactic Dehydrogenase Activities and Zinc Concentrations in Serum , New England J. Med. 255:449-456 ( (Sept. 6) ) 1956;.
Hsieh, K. M.; Suntzeff, V.; and Cowdry, E. V.:  Serum Lactic Dehydrogenase Activity as Indication of Neoplastic Growth and Regression , Proc. Soc. Exper. Biol. & Med. 89:627-629 ( (Aug.) ) 1955;
 Comparative Study of Serum Lactic Dehydrogenase Activity in Mice with Transplanted and Induced Tumors , Cancer Res. 16:237-239 ( (March) ) 1956;.
Zimmerman, H. J.; West, M.; and Weinstein, H. G.:  Serum Lactic Dehydrogenase and Glutamic Oxaloacetic Transaminase Levels in Disease , abstracted, Proc. Central Soc. Clin. Res. 29:100, 1956;.
Ostrow, B. H., and others:  Serum Glutamic-Oxaloacetic Transaminase in Coronary Artery Disease: Review of 201 Cases , Circulation 14:790-799 ( (Nov.) ) 1956;.
LaDue, J. S.; Wróblewski, F.; and Karmen, A.:  Serum Glutamic Oxaloacetic Transaminase Activity in Human Acute Transmural Myocardial Infarction , Science 120:497-499 ( (Sept. 24) ) 1954;.
Chinsky, M.; Shmagranoff, G. L.; and Sherry, S.:  Serum Transaminase Activity: Observations in Large Group of Patients , J. Lab. & Clin. Med. 47:108-118 ( (Jan.) ) 1956;.
Volk, B. W.; Losner, S.; Aronson, S. M.; and Lew, H.:  Serum Aldolase Level in Acute Myocardial Infarction , Am. J. M. Sc. 232:38-43 ( (July) ) 1956;.
Wróblewski, F.; Jervis, G.; and LaDue, J. S.:  Diagnostic, Prognostic and Epidemiologic Significance of Serum Glutamic Oxaloacetic Transaminase (SGO-T ) Alterations in Acute Hepatitis , Ann. Int. Med. 45:782-800 ( (Nov.) ) 1956;.
Wróblewski, F.; and LaDue, J. S.:  Serum Glutamic Pyruvic Transaminase in Hepatic Disease: Preliminary Report , Ann. Int. Med. 45:801-811 ( (Nov.) ) 1956;.
Footnotes 5a, b, and c.
Sibley, J. A., and Fleisher, G. A.:  Clinical Significance of Serum Aldolase , Proc. Staff Meet. Mayo Clin. 29:591-603 ( (Nov. 10) ) 1954;.
Footnotes 2b, 3, and 4a and f.
Footnotes 2b, 3, and 4a.
Footnotes 3 and 4d and e.

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Karmen, A.; Wróblewski, F.; and LaDue, J. S.:  Transaminase Activity in Human Blood , J. Clin. Invest. 34:126-133 ( (Jan.) ) 1955;.
Wróblewski, F., and LaDue, J. S.:  Lactic Dehydrogenase Activity in Blood , Proc. Soc. Exper. Biol. & Med. 90: 210-213 ( (Oct.) ) 1955;.
Wróblewski, F.; Ruegsegger, P., and LaDue, J. S.:  Serum Lactic Dehydrogenase Activity in Acute Transmural Myocardial Infarction , Science 123:1122-1123 ( (June 22) ) 1956;.
Hill, B. R., and Levi, C.:  Elevation of Serum Component in Neoplastic Disease , Cancer Res. 14:513-515 ( (Aug.) ) 1954;.
Hsieh, K. M., and Blumenthal, H. T.:  Serum Lactic Dehydrogenase Levels in Various Disease States , Proc. Soc. Exper. Biol. & Med. 91:626-630 ( (April) ) 1956;.
White, L. P.:  Serum Enzymes: Serum Lactic Dehydrogenase in Myocardial Infarction , New England J. Med. 255:984-988 ( (Nov. 22) ) 1956;.
Wacker, W. E. C.; Ulmer, D. D.; and Vallee, B. L.:  Malic and Lactic Dehydrogenase Activities and Zinc Concentrations in Serum , New England J. Med. 255:449-456 ( (Sept. 6) ) 1956;.
Hsieh, K. M.; Suntzeff, V.; and Cowdry, E. V.:  Serum Lactic Dehydrogenase Activity as Indication of Neoplastic Growth and Regression , Proc. Soc. Exper. Biol. & Med. 89:627-629 ( (Aug.) ) 1955;
 Comparative Study of Serum Lactic Dehydrogenase Activity in Mice with Transplanted and Induced Tumors , Cancer Res. 16:237-239 ( (March) ) 1956;.
Zimmerman, H. J.; West, M.; and Weinstein, H. G.:  Serum Lactic Dehydrogenase and Glutamic Oxaloacetic Transaminase Levels in Disease , abstracted, Proc. Central Soc. Clin. Res. 29:100, 1956;.
Ostrow, B. H., and others:  Serum Glutamic-Oxaloacetic Transaminase in Coronary Artery Disease: Review of 201 Cases , Circulation 14:790-799 ( (Nov.) ) 1956;.
LaDue, J. S.; Wróblewski, F.; and Karmen, A.:  Serum Glutamic Oxaloacetic Transaminase Activity in Human Acute Transmural Myocardial Infarction , Science 120:497-499 ( (Sept. 24) ) 1954;.
Chinsky, M.; Shmagranoff, G. L.; and Sherry, S.:  Serum Transaminase Activity: Observations in Large Group of Patients , J. Lab. & Clin. Med. 47:108-118 ( (Jan.) ) 1956;.
Volk, B. W.; Losner, S.; Aronson, S. M.; and Lew, H.:  Serum Aldolase Level in Acute Myocardial Infarction , Am. J. M. Sc. 232:38-43 ( (July) ) 1956;.
Wróblewski, F.; Jervis, G.; and LaDue, J. S.:  Diagnostic, Prognostic and Epidemiologic Significance of Serum Glutamic Oxaloacetic Transaminase (SGO-T ) Alterations in Acute Hepatitis , Ann. Int. Med. 45:782-800 ( (Nov.) ) 1956;.
Wróblewski, F.; and LaDue, J. S.:  Serum Glutamic Pyruvic Transaminase in Hepatic Disease: Preliminary Report , Ann. Int. Med. 45:801-811 ( (Nov.) ) 1956;.
Footnotes 5a, b, and c.
Sibley, J. A., and Fleisher, G. A.:  Clinical Significance of Serum Aldolase , Proc. Staff Meet. Mayo Clin. 29:591-603 ( (Nov. 10) ) 1954;.
Footnotes 2b, 3, and 4a and f.
Footnotes 2b, 3, and 4a.
Footnotes 3 and 4d and e.
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