EVALUATION OF DRUGS FOR PROTECTION AGAINST MOTION SICKNESS ABOARD TRANSPORT SHIPS: Title and subTitle BreakREPORT OF STUDY BY ARMY, NAVY, AIR FORCE MOTION SICKNESS TEAM FREE

[+] Author Affiliations

Herman I. Chinn, Ph.D., School of Aviation Medicine, Randolph Field, Texas, was principal investigator. Other members of the team were S. Bayne-Jones, M.D., and C. S. Gersoni, Ph.D., Office of Surgeon General, U. S. Army, Washington, D. C.; A. C. Henderson and H. E. Zeransky, Army Medical Research Laboratory, Fort Knox, Ky.; E. H. Schein, Ph.D., Walter Reed Army Medical Center, Washington, D. C.; H. T. Karsner, M.D., R. A. Phillips, M.D., and O. D. Yarbrough, M.D., Bureau of Medicine and Surgery Department of the Navy, Washington, D. C.; G. J. Duffner, M.D., and J. L. Kinsey, M.D., Naval Medical Research Laboratory, New London, Conn.; R. S. Melton, Ph.D., and R. B. Voas, Ph.D., U. S. Naval School of Aviation Medicine, Pensacola, Fla.; M. Jones, Ph.D., Office of Naval Research, Chicago; C. H. Maag, Ph.D., and R. Trumbull, Ph.D., Office of Naval Research, Washington, D. C.; C. C. Shaw, M.D., Philadelphia Navy Shipyard, Philadelphia; P. K. Smith, Ph.D., George Washington University School of Medicine, Washington, D. C.; and R. O. Bauer, M.D., H. M. Sweeney, Ph.D., and N. Weiner, M.D., U. S. Air Force School of Aviation Medicine, Randolph Field, Texas.

This work is not to be construed as necessarily reflecting the views of the Department of Defense.

JAMA. 1956;160(9):755-760. doi:10.1001/jama.1956.02960440027008

Text Size: A A A

Published online

Article

References

ABSTRACT

ABSTRACT | REFERENCES

• Twenty-six compounds have been compared with a placebo as to effectiveness in preventing seasickness in 16,920 soldiers and airmen crossing the Atlantic. The most significant benefit was obtained by using 50 gm. of meclizine once or thrice daily, 50 mg. of cyclizine thrice daily, or 25 mg. promethazine thrice daily.

Four other drugs were demonstrated for the first time to be effective against seasickness. Earlier reports of the effectiveness of scopolamine hydrobromide were verified as to single doses, but on continued use it gave the most distressing sideeffects of all the prophylactics used. For continued use, meclizine was the most satisfactory.

Motion sickness was twice as frequent in those who had had it before as in those with no previous history of it. It was less frequent in the older men, in those who had crossed before, and in those quartered midship.

REFERENCES

ABSTRACT | REFERENCES

Gay, L. N., and Carliner, P. E.: The Prevention and Treatment of Motion Sickness: I. Seasickness , Bull. Johns Hopkins Hosp. 84:470-487, 1949;.

Chinn, H. I.; Noell, W. K., and Smith, P. K.: Prophylaxis of Motion Sickness: Evaluation of Some Drugs in Seasickness , Arch. Int. Med. 86:810-822 ( (Dec.) ) 1950;.

Chinn, H. I.; Handford, S. W.; Cone, T. E., Jr., and Smith, P. K.: The Effectiveness of Various Drugs for the Prophylaxis of Seasickness , Am. J. Med. 12:433-439, 1952;.

Chinn, H. I., and others: Evaluation of Some Drugs in Seasickness , J. Pharmacol. & Exper. Therap. 108:69-79, 1953;.

Handford, S. W.; Cone, T. E., Jr.; Chinn, H. I., and Smith, P. K.: Drugs Preventing Motion Sickness at Sea , J. Pharmacol. & Exper. Therap. 111:447-453, 1954;.

Glaser, E. M.: Side Effects of Remedies for Motion Sickness, Internat . Rec. Med. 168:23-31, 1955;.

Holling, H. E.; McArdle, B., and Trotter, W. R.: Prevention of Seasickness by Drugs , Lancet 1:127-129, 1944;.

Noell, W. K.; Chinn, H. I., and Haberer, C. E.: Electroencephalographic Evaluation of the Sedative Effects of Antihistamine Drugs , Report no. 55-55, Randolph Field, Texas, U. S. A. F. School of Aviation Medicine, 1955;.

Glaser, E. M.: Experiments on Side Effects of Drugs , Brit. J. Pharmacol. 8:187-192, 1953;.

Benkendorf, L.: Über die Behandlung der Seekrankheit , Deutsche med. Wchnschr. 78:393-395, 1953;.

Noble, R. L.: Treatment of Experimental Motion Sickness in Humans , Canad. J. Res., Sec. E 23:10-22, 1946;.

Smith, P. K.: Effect of Various Substances on Swing Sickness , Proc. Soc. Exper. Biol. & Med. 63:209-210, 1946;.

Brand, E. D.; Harris, T. D.; Borison, H. L., and Goodman, L. S.: The Antiemetic Activity of 10-(γ-Dimethylaminopropyl)-2-Chlorophenothiazine (Chlorpromazine) in Dog and Cat , J. Pharmacol. & Exper. Therap. 110:86-92, 1954;.

Cook, L., and Toner, J J.: The Antiemetic Action of Chlorpromazine, SKF No. 2601-A (RP-4560) , abstracted, J. Pharmacol. & Exper. Therap. 110:12, 1954;.

First Page Preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal