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PRECAUTIONS IN PEDIATRIC IMMUNIZATION PROCEDURES FREE

Louis W. Sauer, M.D., Ph.D.
[+] Author Affiliations

This study was aided by a grant from Parke, Davis & Company, Detroit.

Read in part before La Sociedad Cubana de Pediatria, Havana, Cuba, Feb. 24, 1953.


Evanston, Ill

From the Evanston Hospital Whooping Cough Research Laboratory, Northwestern University Medical School, Chicago.


JAMA. 1953;152(14):1314-1317. doi:10.1001/jama.1953.03690140022005
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During the past decade, the simultaneous immunization against diphtheria, tetanus, and pertussis has become quite well established on laboratory and clinical evidence. To retard the elimination of antigen (DTP) from the body and to enhance antitoxin and antibody development, various forms of aluminum have been used as adjuvant. Most private patients are now adequately protected by the customary primary series of three or four monthly doses, and subsequent recall (stimulating or booster) doses. Needless deaths due to pertussis are still occurring, however, in infants and children from families with low incomes and orphanages in congested cities and in rural areas. To reach these children, mass immunization clinics should function at well baby clinics, primary schools, and mobile units. The diverse difficulties encountered in the execution of these immunization procedures are problems due to earlier immunization, febrile reactions, alum cyst, postinoculation encephalopathy, paralytic poliomyelitis of the injected limb, and unfavorable results

REFERENCES

Lovett, B. R., and Hektoen, L.:  Keep Your Baby Away from Whooping Cough , Hygeia 3: 129-130 ( (March) ) 1925;.
Kahn, R. L.: Tissue Immunity , Springfield, Ill., Charles C Thomas, Publisher, 1936;, p. 628.
Sauer, L. W.:  Whooping Cough: A Study in Immunization , J. A. M. A. 100:239-241 ( (Jan. 28) ) 1933;
 Immunization with Bacillus Pertussis Vaccine , SauerJ. A. M. A. 101:1449-1451 ( (Nov. 4) ) 1933;
 The Age Factor in Active Immunization Against Whooping Cough , Am. J. Path. 17:719-723 ( (Sept.) ) 1941;.
Sako, W.; Treuting, W. L.; Witt, D. B., and Nichamin, S. J.:  Early Immunization Against Pertussis with Alum Precipitated Vaccine , J. A. M. A. 127:379-383 ( (Feb. 17) ) 1945;.
McComb, J. A., and Trafton, M. Z.:  Immune Responses and Reactions to Diphtheria and Tetanus Toxoids, with Pertussis Vaccine, Aluminum Phosphate Precipitated , New England J. Med. 243: 442-444 ( (Sept. 21) ) 1950;.
Miller, J. J., Jr., and others: Report of the Committee on Immunization and Therapeutic Procedures , Evanston, Ill., Am. Acad. Pediatrics, 1952;.
Byers, R. K., and Moll, F. C.:  Encephalopathies Following Prophylactic Pertussis Vaccine , Pediatrics 1: 437-457 ( (April) ) 1948;.
Toomey, J. A.:  Reaction to Pertussis Vaccine , J. A. M. A. 139: 448-450 ( (Feb. 12) ) 1949;.
 Poliomyelitis and Prophylactic Immunization, editorial , J. A. M. A. 144:240-241 ( (Sept. 16) ) 1950;.
Faber, H. K.:  Postinoculation Poliomyelitis, editorial , Pediatrics 7:300-304 ( (Feb.) ) 1951;.
Medical Research Council: The Sterilization, Use and Care of Syringes , War Memorandum No. 15, London, His Majesty's Stationery Office, 1945;.
A few seconds should elapse for its antiseptic action. Early in 1952, following Faber's technique, 2% tincture of iodine was used; later, 1% in 70% alcohol was tried. Profuse lacrimation and frequent desquamation of the skin site made me resume use of 70% denatured ethyl alcohol.

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Lovett, B. R., and Hektoen, L.:  Keep Your Baby Away from Whooping Cough , Hygeia 3: 129-130 ( (March) ) 1925;.
Kahn, R. L.: Tissue Immunity , Springfield, Ill., Charles C Thomas, Publisher, 1936;, p. 628.
Sauer, L. W.:  Whooping Cough: A Study in Immunization , J. A. M. A. 100:239-241 ( (Jan. 28) ) 1933;
 Immunization with Bacillus Pertussis Vaccine , SauerJ. A. M. A. 101:1449-1451 ( (Nov. 4) ) 1933;
 The Age Factor in Active Immunization Against Whooping Cough , Am. J. Path. 17:719-723 ( (Sept.) ) 1941;.
Sako, W.; Treuting, W. L.; Witt, D. B., and Nichamin, S. J.:  Early Immunization Against Pertussis with Alum Precipitated Vaccine , J. A. M. A. 127:379-383 ( (Feb. 17) ) 1945;.
McComb, J. A., and Trafton, M. Z.:  Immune Responses and Reactions to Diphtheria and Tetanus Toxoids, with Pertussis Vaccine, Aluminum Phosphate Precipitated , New England J. Med. 243: 442-444 ( (Sept. 21) ) 1950;.
Miller, J. J., Jr., and others: Report of the Committee on Immunization and Therapeutic Procedures , Evanston, Ill., Am. Acad. Pediatrics, 1952;.
Byers, R. K., and Moll, F. C.:  Encephalopathies Following Prophylactic Pertussis Vaccine , Pediatrics 1: 437-457 ( (April) ) 1948;.
Toomey, J. A.:  Reaction to Pertussis Vaccine , J. A. M. A. 139: 448-450 ( (Feb. 12) ) 1949;.
 Poliomyelitis and Prophylactic Immunization, editorial , J. A. M. A. 144:240-241 ( (Sept. 16) ) 1950;.
Faber, H. K.:  Postinoculation Poliomyelitis, editorial , Pediatrics 7:300-304 ( (Feb.) ) 1951;.
Medical Research Council: The Sterilization, Use and Care of Syringes , War Memorandum No. 15, London, His Majesty's Stationery Office, 1945;.
A few seconds should elapse for its antiseptic action. Early in 1952, following Faber's technique, 2% tincture of iodine was used; later, 1% in 70% alcohol was tried. Profuse lacrimation and frequent desquamation of the skin site made me resume use of 70% denatured ethyl alcohol.
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