0
ARTICLE |

CLINICAL-ELECTROENCEPHALOGRAPHIC CORRELATIONS, WITH SPECIAL REFERENCE TO EPILEPSY FREE

Abraham Wikler, M.D.
[+] Author Affiliations

Read at the Meeting of the American Psychiatric Association, Cincinnati, May 10, 1951.


JAMA. 1952;149(15):1365-1368. doi:10.1001/jama.1952.02930320005002
Text Size: A A A
Published online

Although correlations of a high degree of statistical significance have been demonstrated between changes in the electroencephalogram and certain clinical conditions, notably in epilepsy and focal organic brain lesions, every electroencephalographer is aware that dissociation of the electroencephalographic pattern and the clinical status is not uncommon. To the investigator, these facts are of great importance, since they suggest clues regarding the functional significance of rhythmical cortical electrical activity. From the clinician's standpoint, however, such discrepancies are disappointing; for, in spite of logical reasons to the contrary,1 the hope is still widespread that a laboratory test will someday be found that will furnish clinical diagnoses. Experience with electroencephalography has shown that this is not the case, but the view is still prevalent that with the aid of the electroencephalogram one can distinguish between "functional" (usually meaning psychogenic) and "organic" (usually meaning nonpsychogenic) states.

It is the purpȯse of this paper

REFERENCES

Wikler, A.:  A Critical Analysis of Some Current Concepts in Psychiatry: Implications of Monistic Mind-Body Concept for Diagnosis, Research, Etiology and Treatment , Psychosom. Med. 14: 10-17 ( (Jan.) -Feb.) 1952;.
Wikler, A.: Unpublished data.
Gorman, W. F.; Stearns, E., and Wortis, S. B.:  The Electroencephalogram in Korsakoff Syndrome , Am. J. Psychiat. 107:20-24 ( (July) ) 1950;.
Romano, J., and Engel, G. L.:  Delirium: Electroencephalographic Data , Arch. Neurol. & Psychiat. 51:356-377 ( (April) ) 1944;.
Engel, G. L.:  The Clinical Applications of Electroencephalography , Cincinnati J. Med. 27: 151-181 ( (March) ) 1946;.
Wikler, A.:  Effects of Large Doses of N-Allylnormorphine on Man , Federation Proc. 10: 345 ( (March) ) 1951;.
Isbell, H., and others:  Liability of Addiction to 6-Dimethylamino-4-4-Diphenyl-3-Heptanone (Methadon, "Amidone" or "10820") in Man , Arch. Int. Med. 82:362-396 ( (Oct.) ) 1948;.
Cahen, R. L., and Wikler, A.:  Effects of Morphine on Cortical Electrical Activity of the Rat , Yale J. Biol. & Med. 16: 239-243 ( (Jan.) ) 1944;.
Magoun, H. W.:  Caudal and Cephalic Influences of the Brain Stem Reticular Formation , Physiol. Rev. 30:459-474 ( (Oct.) ) 1950;.
Jasper, H. H.:  Symposium: Thalmocortical Relationships: Diffuse Projective Systems: The Integrative Action of the Thalamic Reticular System , Electroencephalog. & Clin. Neurophysiol. 1: 405:420 ( (Nov.) ) 1949;.
Jasper, H. H., and Andrews, H. L.:  Brain Potentials and Voluntary Muscle Activity in Man , J. Neurophysiol. 1: 87-100 ( (March) ) 1938;.
Jasper, H. H.:  Electrical Signs of Epileptic Discharge , Electroencephalog. & Clin. Neurophysiol. 1:11-18 ( (Feb.) ) 1949;.
Wikler, A.:  Effects of Pitressin Hydration on the Electroencephalogram: Paroxysmal Slow Activity in Nonepileptic Patients with Previous Drug Addiction , Arch. Neurol. & Psychiat. 57:78-83 ( (Jan.) ) 1947;.
White, J. M., and Giarman, N. J.:  Electroencephalographic Changes in the Anesthetized Dog Produced by Intravenous Procaine , J. Pharmacol. & Exper. Therap. 101:37 ( (Jan.) ) 1951;.
Gibbs, E. L.; Gibbs, F. A., and Fuster, B.:  Psychomotor Epilepsy , Arch. Neurol. & Psychiat. 60:331-339 ( (Oct.) ) 1948;.
Jasper, H.; Pertuisset, B., and Flanigin, H.:  EEG and Cortical Electrograms in Patients with Temporal Lobe Seizures , Arch. Neurol. & Psychiat. 65:272-291 ( (March) ) 1951;.
Masland, R. L., and Rosenblum, M.:  Subjective Symptoms in Temporal Lobe Disease: Their Enhancement by Anticonvulsant Therapy , abstracted, American Electroencephalographic Society ( (June 10) -11) 1950;.
Jasper, H. H.:  Electroencephalography , in Penfield, W., and Erickson, T. C.: Epilepsy and Cerebral Localization , Springfield, Ill., Charles C Thomas, Publisher, 1941;, pp. 1-623.
Wikler, A.:  Sites and Mechanisms of Action of Morphine and Related Drugs in the Central Nervous System , Pharmacol. Rev. 2: 435-506
J. Pharmacol. & Exper. Therap. 100 ( (Dec.) ) 1950;.
Pitts, W., and McCulloch, W. S.:  How We Know Universals: The Perception of Auditory and Visual Forms , Bull. Math. Biophysics 9: 127-147, 1947;.
Walter, W. G.:  The Twenty-fourth Maudsley Lecture: The Functions of Electrical Rhythms in the Brain , J. Ment. Sc. 96:1-31 ( (Jan.) ) 1950;.
Magoun, H. W.: Discussion of paper by Jasper.10
Wikler, A.: Clinical and Electroencephalographic Studies on the Effects of Mescaline, N-Allylnormorphine and Morphine in Man: A Pharmacologic Analysis of the Functions of the Spontaneous Electrical Activity of the Cerebral Cortex, to be published.

First Page Preview

First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Wikler, A.:  A Critical Analysis of Some Current Concepts in Psychiatry: Implications of Monistic Mind-Body Concept for Diagnosis, Research, Etiology and Treatment , Psychosom. Med. 14: 10-17 ( (Jan.) -Feb.) 1952;.
Wikler, A.: Unpublished data.
Gorman, W. F.; Stearns, E., and Wortis, S. B.:  The Electroencephalogram in Korsakoff Syndrome , Am. J. Psychiat. 107:20-24 ( (July) ) 1950;.
Romano, J., and Engel, G. L.:  Delirium: Electroencephalographic Data , Arch. Neurol. & Psychiat. 51:356-377 ( (April) ) 1944;.
Engel, G. L.:  The Clinical Applications of Electroencephalography , Cincinnati J. Med. 27: 151-181 ( (March) ) 1946;.
Wikler, A.:  Effects of Large Doses of N-Allylnormorphine on Man , Federation Proc. 10: 345 ( (March) ) 1951;.
Isbell, H., and others:  Liability of Addiction to 6-Dimethylamino-4-4-Diphenyl-3-Heptanone (Methadon, "Amidone" or "10820") in Man , Arch. Int. Med. 82:362-396 ( (Oct.) ) 1948;.
Cahen, R. L., and Wikler, A.:  Effects of Morphine on Cortical Electrical Activity of the Rat , Yale J. Biol. & Med. 16: 239-243 ( (Jan.) ) 1944;.
Magoun, H. W.:  Caudal and Cephalic Influences of the Brain Stem Reticular Formation , Physiol. Rev. 30:459-474 ( (Oct.) ) 1950;.
Jasper, H. H.:  Symposium: Thalmocortical Relationships: Diffuse Projective Systems: The Integrative Action of the Thalamic Reticular System , Electroencephalog. & Clin. Neurophysiol. 1: 405:420 ( (Nov.) ) 1949;.
Jasper, H. H., and Andrews, H. L.:  Brain Potentials and Voluntary Muscle Activity in Man , J. Neurophysiol. 1: 87-100 ( (March) ) 1938;.
Jasper, H. H.:  Electrical Signs of Epileptic Discharge , Electroencephalog. & Clin. Neurophysiol. 1:11-18 ( (Feb.) ) 1949;.
Wikler, A.:  Effects of Pitressin Hydration on the Electroencephalogram: Paroxysmal Slow Activity in Nonepileptic Patients with Previous Drug Addiction , Arch. Neurol. & Psychiat. 57:78-83 ( (Jan.) ) 1947;.
White, J. M., and Giarman, N. J.:  Electroencephalographic Changes in the Anesthetized Dog Produced by Intravenous Procaine , J. Pharmacol. & Exper. Therap. 101:37 ( (Jan.) ) 1951;.
Gibbs, E. L.; Gibbs, F. A., and Fuster, B.:  Psychomotor Epilepsy , Arch. Neurol. & Psychiat. 60:331-339 ( (Oct.) ) 1948;.
Jasper, H.; Pertuisset, B., and Flanigin, H.:  EEG and Cortical Electrograms in Patients with Temporal Lobe Seizures , Arch. Neurol. & Psychiat. 65:272-291 ( (March) ) 1951;.
Masland, R. L., and Rosenblum, M.:  Subjective Symptoms in Temporal Lobe Disease: Their Enhancement by Anticonvulsant Therapy , abstracted, American Electroencephalographic Society ( (June 10) -11) 1950;.
Jasper, H. H.:  Electroencephalography , in Penfield, W., and Erickson, T. C.: Epilepsy and Cerebral Localization , Springfield, Ill., Charles C Thomas, Publisher, 1941;, pp. 1-623.
Wikler, A.:  Sites and Mechanisms of Action of Morphine and Related Drugs in the Central Nervous System , Pharmacol. Rev. 2: 435-506
J. Pharmacol. & Exper. Therap. 100 ( (Dec.) ) 1950;.
Pitts, W., and McCulloch, W. S.:  How We Know Universals: The Perception of Auditory and Visual Forms , Bull. Math. Biophysics 9: 127-147, 1947;.
Walter, W. G.:  The Twenty-fourth Maudsley Lecture: The Functions of Electrical Rhythms in the Brain , J. Ment. Sc. 96:1-31 ( (Jan.) ) 1950;.
Magoun, H. W.: Discussion of paper by Jasper.10
Wikler, A.: Clinical and Electroencephalographic Studies on the Effects of Mescaline, N-Allylnormorphine and Morphine in Man: A Pharmacologic Analysis of the Functions of the Spontaneous Electrical Activity of the Cerebral Cortex, to be published.
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.