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EFFECT OF CANCER ON LIVER ENZYMES FREE

Jesse P. Greenstein, Ph.D.
[+] Author Affiliations

Read before the Section on Pathology and Physiology at the One-Hundredth Annual Session of the American Medical Association, Atlantic City, June 13, 1951.


JAMA. 1952;148(9):697-699. doi:10.1001/jama.1952.02930090007002
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There are two general approaches that the chemical analyst may employ in the study of malignant disease. The first of these is the direct chemical analysis of tumors, and comparison of such findings with those obtained in identical fashion on normal tissues and organs. The second approach is the chemical analysis of the tissues, circulating fluids, secretions, and excreta of cancerous patients, and comparison of such findings with those obtained on the same materials from normal persons. In the former case, it is expected that such information will yield a picture of the chemical processes inherent in the neoplastic transformation of tissues. In the latter case, it is expected that such information will give a description of the systemic effects induced by a tumor on the host that bears it, at a site or sites removed from the tumor, and in a state free of metastatic involvement. It is with

REFERENCES

Greenstein, J. P.: Biochemistry of Cancer , New York, Academic Press, Inc., 1947;.
Brahn, B.:  Further Researches on the Enzymes in the Liver of the Cancerous , Sitzungsber. kgl. Preuss. Akad. Wissensch. 20:478-481, 1916;.
Weil-Malherbe, H., and Schade, R.:  Studies on the Liver Catalase of Normal and Cancerous Rats , Biochem. J. 43:118-125, 1948;.
Dounce, A. L., and Shanewise, R. P.:  Liver Catalase of Tumor Bearing and Leprous Rats , Cancer Res. 10: 103-107, 1950;.
von Euler, U. S., and Heller, L.:  Katalaseaktivität in Leberfraktionen normaler und sarkomtragender Ratten , Ztschr. Krebsforsch. 56: 393-406, 1949;.
Adams, D. H.:  The Mechanism of the Liver Catalase Depressing Action of Tumours in Mice , Brit. J. Cancer 4: 183-195, 1950;.
Appleman, D.; Skavinski, E. R., and Stein, A. M.:  Catalase Studies on Normal and Cancerous Rats , Cancer Res. 10:498-505, 1950;.
Begg, R. W.:  Systemic Effects of Tumors in Rats , Cancer Res. 11: 341-344, 1951;.
Nakahara, W., and Fukuoka, F.:  A Toxic Cancer Tissue Constituent as Evidenced by Its Effect on Liver Catalase Activity , Japan. M. J. 1:271-276, 1948;
 Toxohormone, a Characteristic Toxic Substance Produced by Cancer Tissue , Gann 40:45-69, 1949;.
Nakahara, W., and Fukuoka, F.:  Purification of Toxohormone: A Second Study on Toxohormone, a Characteristic Toxic Substance Produced by Cancer Tissues , Gann 41:47-55, 1950;.
Greenfield, R. E., and Meister, A.: J. Nat. Cancer Inst. , to be published.
Fukuoka, F., and Nakahara, W.:  Mode of Action of Toxohormone: A Third Study of Toxohormone, a Characteristic Toxic Substance Produced by Cancer Tissue , Gann 42:55-67, 1951;.
Fiala, S., and Burk, D.:  On the Mode of Iron-Binding by Siderophilin, Conalbumin, Hydroxylamine, Aspergillic Acid, and Other Hydroxamic Acids, Letters to the Editor , Arch. Biochem. 20: 172-175, 1949;.

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Greenstein, J. P.: Biochemistry of Cancer , New York, Academic Press, Inc., 1947;.
Brahn, B.:  Further Researches on the Enzymes in the Liver of the Cancerous , Sitzungsber. kgl. Preuss. Akad. Wissensch. 20:478-481, 1916;.
Weil-Malherbe, H., and Schade, R.:  Studies on the Liver Catalase of Normal and Cancerous Rats , Biochem. J. 43:118-125, 1948;.
Dounce, A. L., and Shanewise, R. P.:  Liver Catalase of Tumor Bearing and Leprous Rats , Cancer Res. 10: 103-107, 1950;.
von Euler, U. S., and Heller, L.:  Katalaseaktivität in Leberfraktionen normaler und sarkomtragender Ratten , Ztschr. Krebsforsch. 56: 393-406, 1949;.
Adams, D. H.:  The Mechanism of the Liver Catalase Depressing Action of Tumours in Mice , Brit. J. Cancer 4: 183-195, 1950;.
Appleman, D.; Skavinski, E. R., and Stein, A. M.:  Catalase Studies on Normal and Cancerous Rats , Cancer Res. 10:498-505, 1950;.
Begg, R. W.:  Systemic Effects of Tumors in Rats , Cancer Res. 11: 341-344, 1951;.
Nakahara, W., and Fukuoka, F.:  A Toxic Cancer Tissue Constituent as Evidenced by Its Effect on Liver Catalase Activity , Japan. M. J. 1:271-276, 1948;
 Toxohormone, a Characteristic Toxic Substance Produced by Cancer Tissue , Gann 40:45-69, 1949;.
Nakahara, W., and Fukuoka, F.:  Purification of Toxohormone: A Second Study on Toxohormone, a Characteristic Toxic Substance Produced by Cancer Tissues , Gann 41:47-55, 1950;.
Greenfield, R. E., and Meister, A.: J. Nat. Cancer Inst. , to be published.
Fukuoka, F., and Nakahara, W.:  Mode of Action of Toxohormone: A Third Study of Toxohormone, a Characteristic Toxic Substance Produced by Cancer Tissue , Gann 42:55-67, 1951;.
Fiala, S., and Burk, D.:  On the Mode of Iron-Binding by Siderophilin, Conalbumin, Hydroxylamine, Aspergillic Acid, and Other Hydroxamic Acids, Letters to the Editor , Arch. Biochem. 20: 172-175, 1949;.
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