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TOPICAL BACITRACIN THERAPY OF PYOGENIC DERMATOSES: Title and subTitle BreakA Clinical Report FREE

JACK L. DERZAVIS, M.D.MAJOR ; J. SIDNEY RICELIEUTENANT COLONEL ; LOUIS S. LELAND
[+] Author Affiliations

Bacitracin used in this study was donated by Commercial Solvents Corporation, New York.

Instructor in Dermatology, Georgetown University School of Medicine, and attending staff physician, Walter Reed General Hospital (Dr. Derzavis).

The opinions expressed are those of the authors and are not to be considered the official opinion of the medical department of the United States Army.

Clinical studies herein reported were carried out at the Walter Reed General Hospital and in the Division of Dermatology, Georgetown University Service, Gallinger Municipal Hospital.


JAMA. 1949;141(3):191-192. doi:10.1001/jama.1949.02910030021005
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The literature is replete with evidence of the high index of allergenicity of the more effective agents used in the therapy of the various pyodermas. The alarming incidence of the apparent induction of hypersensitivity to such valuable medicaments as sulfonamide drugs and penicillin when they are used topically to treat the minor dermatoses, thus vitiating their future usefulness in generalized and systemic infections, has prompted the cautioning editorial by Sulzberger and Baer in the "Year Book of Dermatology."1 It is therefore expedient that information concerning the useful and less allergenic therapeutic agents be promulgated widely. We are reporting some significant clinical results which we have noted following the topical administration of a new antibiotic, bacitracin. These results corroborate the findings of Miller, Slatkin and Johnson reported recently in the Journal of Investigative Dermatology.2

HISTORICAL DATA  In Science (Oct. 12, 1945) Johnson, Anker and Meleney3 reported the recovery

REFERENCES

Sulzberger, M. B., and Baer, R.: Editorial Year Book of Dermatology , Chicago, The Year Book Publishers, Inc., 1946;.
Miller, J. L.; Slatkin, M. H., and Johnson, B. A.:  Local Use of Bacitracin , J. Invest. Dermat. 10: 179 ( (March) ) 1948;.
Johnson, B. A.; Anker, H., and Meleney, F. L.:  Bacitracin; A New Antibiotic Produced by a Member of the B. Subtilis Group , Science 102: 376 ( (Oct. 12) ) 1945;.
Meleney, F. L., and Johnson, B.:  Bacitracin Therapy; The First Hundred Cases of Surgical Infections Treated Locally with the Antibiotics . J. A. M. A. 13:675 ( (March 8) ) 1947;.
Scudi, J. V., and Antopol, W.:  Some Pharmacological Characteristics of Bacitracin , Proc. Soc. Exper. Biol. & Med. 64:503 ( (April) ) 1947;.
Scudi, J. V.; Clift, M. E., and Krueger, R. A.:  Some Pharmacological Characteristics of Bacitracin: II. Absorption and Excretion of Bacitracin in the Dog , Proc. Soc. Exper. Biol. & Med. 65: 9 ( (May) ) 1947;.
Eagle, H.; Newman, E. V.; Grief, R.; Burholden, T. M., and Goodman, S. C.:  The Blood Levels and Renal Clearance in Rabbits and Man of an Antibiotic Derived from B. subtilis (Bacitracin) , J. Clin. Investigation 26:919 ( (Sept.) ) 1947;.

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Sulzberger, M. B., and Baer, R.: Editorial Year Book of Dermatology , Chicago, The Year Book Publishers, Inc., 1946;.
Miller, J. L.; Slatkin, M. H., and Johnson, B. A.:  Local Use of Bacitracin , J. Invest. Dermat. 10: 179 ( (March) ) 1948;.
Johnson, B. A.; Anker, H., and Meleney, F. L.:  Bacitracin; A New Antibiotic Produced by a Member of the B. Subtilis Group , Science 102: 376 ( (Oct. 12) ) 1945;.
Meleney, F. L., and Johnson, B.:  Bacitracin Therapy; The First Hundred Cases of Surgical Infections Treated Locally with the Antibiotics . J. A. M. A. 13:675 ( (March 8) ) 1947;.
Scudi, J. V., and Antopol, W.:  Some Pharmacological Characteristics of Bacitracin , Proc. Soc. Exper. Biol. & Med. 64:503 ( (April) ) 1947;.
Scudi, J. V.; Clift, M. E., and Krueger, R. A.:  Some Pharmacological Characteristics of Bacitracin: II. Absorption and Excretion of Bacitracin in the Dog , Proc. Soc. Exper. Biol. & Med. 65: 9 ( (May) ) 1947;.
Eagle, H.; Newman, E. V.; Grief, R.; Burholden, T. M., and Goodman, S. C.:  The Blood Levels and Renal Clearance in Rabbits and Man of an Antibiotic Derived from B. subtilis (Bacitracin) , J. Clin. Investigation 26:919 ( (Sept.) ) 1947;.
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