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September 11, 1948, Vol 138, No. 2 >
ARTICLE | September 11, 1948

A NEW VEHICLE FOR PARENTERAL REPOSITORY PENICILLIN THERAPY FREE

N. ERCOLI, M.D.; W. C. HUEPER, M.D.; L. LANDIS, M.S.; B. S. SCHWARTZ, M.A.; F. J. QUEALLY, M.D.
[+] Author Affiliations

New York

From the Division of Pharmacology and Chemotherapy, Warner Institute for Therapeutic Research, and the Medical Department, William R. Warner & Co., Inc.


JAMA. 1948;138(2):115-117. doi:10.1001/jama.1948.02900020011003
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References

The development of a simple and efficient method for maintaining and prolonging an effective plasma level of penicillin and for reducing thereby the number of intramuscular or subcutaneous injections necessary has been the subject of various investigations during the last few years. In all instances, it was attempted to slow the absorption of the penicillin from the site of injection by incorporating the antibiotic either into a mixture of wax and oil1 or into water in oil emulsions2 or into an oily vehicle3 or into complex vehicles containing vasoconstricting agents.4 The greatest success in this respect has been attained by the penicillinwax-oil mixture of Romansky. However, the high melting point and the considerable viscosity of this preparation require special syringes, and the occasional occurrence of painful indurations and abscesses at the site of the injection is an undesirable complication.

An injectable preparation of penicillin, which can

REFERENCES

1 +
Romansky, M. J., and Rittman, G. E.:  Method of Prolonging Action of Penicillin , Science 100: 196, 1944;.
2 +
Romansky, M. J.:  The Current Status of Calcium Penicillin in Beeswax and Peanut Oil , Am. J. Med. 1: 395, 1946;.
3 +
Freund, J., and Thomson. K. J.:  Simple, Rapid Technique of Preparing Water-in-Oil Emulsions of Penicillin, Drugs and Biologics , Science 101:468, 1945;.
4 +
Cohn, A.; Kornblith, B. A.; Grunstein, I.; Freund, J., and Thomson, K. J.:  Treatment of Gonorrhea with Penicillin , J. Ven. Dis. Inform. 27:154, 1946;.
5 +
Harris, H. W.; Wilcox, C., and Finland, M.:  Plasma Levels After Repository Injections of Penicillin in Water-in-Oil Emulsions , Proc. Soc. Exper. Biol. & Med. 63:199, 1946;.
6 +
Ory, E. M.; Wilcox, C., and Finland, M.:  Serum Levels After Repository Injections of Penicillin , Proc. Soc. Exper. Biol. & Med. 62:86, 1946;.
7 +
Cannon, A. B.; Lindstrom, K., and Ospeck, A. B.:  Maintenance of Penicillin Blood Levels After a Single Intramuscular Injection of Penicillin in Various Oils , Science 104:414, 1946;.
8 +
Senger, F. L.; Warres, H. L., and Rifkin, I.:  Penicillin in Propylene Glycol , J. Urol. 55: 138, 1946;.
9 +
Doll, E. R., and Dimrock, W. W.:  Efficacy of Various Agents for Delaying Absorption of Penicillin , J. Am. Vet. M. A. 108:310, 1946;.
10 +
A number of other liquid repository preparations ("procaine penicillin," "liquid Romansky") with prolonged action have appeared on the market since the submittal of this paper for publication.
11 +
Rammelkamp, C. H.:  Method for Determining Concentration of Penicillin in Body Fluids and Exudate , Proc. Soc. Exper. Biol. & Med. 51:95, 1942;.
12 +
Ercoli, N.; Hueper, W. C; Schachter, R. J.; Schwartz, B. S., and Whitehead, M.: To be published.
13 +
Cohn, A., and Kornblith, B. A.:  Single Injection Treatment of Gonorrhea with Potassium Penicillin Suspension in Oil Containing Epinephrine , Am. J. M. Sc. , to be published.

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1 +
Romansky, M. J., and Rittman, G. E.:  Method of Prolonging Action of Penicillin , Science 100: 196, 1944;.
2 +
Romansky, M. J.:  The Current Status of Calcium Penicillin in Beeswax and Peanut Oil , Am. J. Med. 1: 395, 1946;.
3 +
Freund, J., and Thomson. K. J.:  Simple, Rapid Technique of Preparing Water-in-Oil Emulsions of Penicillin, Drugs and Biologics , Science 101:468, 1945;.
4 +
Cohn, A.; Kornblith, B. A.; Grunstein, I.; Freund, J., and Thomson, K. J.:  Treatment of Gonorrhea with Penicillin , J. Ven. Dis. Inform. 27:154, 1946;.
5 +
Harris, H. W.; Wilcox, C., and Finland, M.:  Plasma Levels After Repository Injections of Penicillin in Water-in-Oil Emulsions , Proc. Soc. Exper. Biol. & Med. 63:199, 1946;.
6 +
Ory, E. M.; Wilcox, C., and Finland, M.:  Serum Levels After Repository Injections of Penicillin , Proc. Soc. Exper. Biol. & Med. 62:86, 1946;.
7 +
Cannon, A. B.; Lindstrom, K., and Ospeck, A. B.:  Maintenance of Penicillin Blood Levels After a Single Intramuscular Injection of Penicillin in Various Oils , Science 104:414, 1946;.
8 +
Senger, F. L.; Warres, H. L., and Rifkin, I.:  Penicillin in Propylene Glycol , J. Urol. 55: 138, 1946;.
9 +
Doll, E. R., and Dimrock, W. W.:  Efficacy of Various Agents for Delaying Absorption of Penicillin , J. Am. Vet. M. A. 108:310, 1946;.
10 +
A number of other liquid repository preparations ("procaine penicillin," "liquid Romansky") with prolonged action have appeared on the market since the submittal of this paper for publication.
11 +
Rammelkamp, C. H.:  Method for Determining Concentration of Penicillin in Body Fluids and Exudate , Proc. Soc. Exper. Biol. & Med. 51:95, 1942;.
12 +
Ercoli, N.; Hueper, W. C; Schachter, R. J.; Schwartz, B. S., and Whitehead, M.: To be published.
13 +
Cohn, A., and Kornblith, B. A.:  Single Injection Treatment of Gonorrhea with Potassium Penicillin Suspension in Oil Containing Epinephrine , Am. J. M. Sc. , to be published.

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