Caronamide is 4'-carboxyphenylmethanesulfonanilide and is prepared by Sharp & Dohme, Inc., Philadelphia.
Meakins, J. C.; Smith, F., and Gold, M. A.: A Comparative Study of Some Commercial Preparations of Oral Penicillin , Canad. M. A. J. 55:97-101 (
(Aug.)
) 1946;.
Rammelkamp, C. H., and Bradley, S. W.: Excretion of Penicillin in Man , Proc. Soc. Exper. Biol. & Med. 53:30-32 (
(May)
) 1943;.
Beyer, K. H.; Woodward, R.; Peters, L.; Verwey, W. F., and Mattis, is, P. A.:: The Prolongation of Penicillin Retention in the Body by Means of Para-Aminohippuric Acid , Science 100: 107-108 (
(Aug. 4)
) 1944;.
Beyer, K. H.; Flippin, H.; Verwey, W. F., and Woodward, R.: The Effect of Para-Aminohippuric Acid on Plasma Concentration of Penicillin in Man , J. A. M. A. 126:1007-1009 (
(Dec. 16)
) 1944;.
Bronfenbrenner, J., and Favour, C. B.: Increasing and Prolonging Blood Penicillin Concentrations Following Intramuscular Administration . Science 101:673-674 (
(June 29)
) 1945;.
Spaulding, E. H.; Bondi, A., Jr., and Early, E.: The Effect of Combining Sodium Benzoate with Oral Penicillins , Science 105:210-211 (
(Feb. 21)
) 1947;.
Abraham, E. P.; Chain, E.; Fletcher, C. M.; Gardner, A. D.; Heatley, N. G.; Jennings, M. A., and Florey, H. W.: Further Observations on Penicillin , Lancet 2: 177-189 (
(Aug. 16)
) 1941;.
Rake, G., and Richardson, A. P.: Pharmacology of Penicillin , Ann. New York Acad. Sc. 48:143-174 (
(Sept. 27)
) 1946;.
Beyer, K. H.: New Concept of Competitive Inhibition of the Renal Tubular Excretion of Penicillin , Science 105:94-95 (
(Jan. 24)
) 1947;.
Beyer, K. H.; Verwey, W. F.; Woodward, R.; Peters, L., and Mattis, P. A.: The Enhancement of the Plasma Concentration of Penicillin in Dogs by the Simultaneous Administration of Para-Aminohippuric Acid , Am. J. M. Sc. 209:608-621 (
(May)
) 1945;.
Beyer, K. H.; Peters, L.; Woodward, R., and Verwey, W. F.: The Enhancement of the Physiological Economy of Penicillin in Dogs by the Simultaneous Administration of Para-Aminohippuric Acid , J. Pharmacol. & Exper. Therap. 82: 310-323 (
(Dec.)
) 1944;.
Beyer, K. H.; Mattis, P. A.; Patch, E. A., and Russo, H. F.: Para-Aminohippuric Acid: Its Pharmacodynamic Actions , J. Pharmacol. & Exper. Therap. 84: 136-146 (
(June)
) 1945;.
Loewe, L.; Rosenblatt, P., and Alture-Werber, E.: A Refractory Case of Subacute Bacterial Endocarditis Due to Veillonella Gazogenes Clinically Arrested by a Combination of Penicillin, Sodium Para-Aminohippurate, and Heparin , Am. Heart J. 32: 327-338 (
(Sept.)
) 1946;.
Avery, N. L., Jr.; Mayer, O. B., and Nelson, R. C.: Massive Doses of Penicillin in the Treatment of Subacute Bacterial Endocarditis , Ann. Int. Med. 24:900-904 (
(May)
) 1946;.
Mokotoff, R.; Brams, W.; Katz, L. N., and Howell, K. M.: The Treatment of Bacterial Endocarditis with Penicillin: Results of Seventeen Consecutive Unselected Cases , Am. J. M. Sc. 211:395-416 (
(April)
) 1946;.
Sprague, J. M.; Ziegler, C.; Cragoe, E. J., and Miller, C. S.: 4'-Carboxyphenylmethanesulfonanilide, to be published.
Beyer, K. H.; Miller, A. K.; Russo. H. F.; Patch, E. A., and Verwey, W. F.: The Inhibitory Effect of Caronamide on the Renal Elimination of Penicillin , Am. J. Physiol. , to be published.
Beyer, K. H.; Russo, H. F.; Patch, E. A., and Tillson, E. A.: Caronamide: Its Pharmacologic Properties, to be published.
Beyer, K. H.; McKinney, S. E.; Tillson, E. A., and Green, C. W.: Caronamide: Its Toxicologic Effects, to be published.
Verwey, W. F., and Miller, A. K.: The Effect of Caronamide upon Penicillin Therapy of Experimental Pneumococcus and Typhoid Infections in Mice, to be published.
All penicillin assays were supervised by one of us (A. K. M.) and were performed by the staff of the Department of Bacteriology, Medical Research Division of Sharp & Dohme, Inc.