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ARTICLE |

TREATMENT OF EARLY SYPHILIS WITH PENICILLIN FREE

THOMAS H. STERNBERG, M.D.; WILLIAM LEIFER, M.D.
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Read before the Section on Dermatology and Syphilology at the Ninety-Fifth Annual Session of the American Medical Association, San Francisco, July 4, 1946.


Los Angeles; New York


JAMA. 1947;133(1):1-5. doi:10.1001/jama.1947.02880010003001
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In a previous paper1 we presented the results of the treatment of early syphilis with the twenty-six weeks' oxophenarsine hydrochloride—bismuth schedule which was adopted by the Army in July 1942. It was shown that this schedule was of relatively low toxicity and yielded a high proportion of satisfactory therapeutic results. Its eventual replacement as the standard therapeutic procedure came about mainly because it failed to meet Army requirements for a short intensive schedule for soldiers under field or combat conditions and because of the demonstration that penicillin was a potent antisyphilitic agent.

Encouraged by the pioneer experiments of Mahoney, Arnold and Harris,2 the extensive investigations of the Subcommittee on Venereal Disease, National Research Council3 and certain pilot studies within the Army,4 the Surgeon General in 1944, on recommendation of the National Research Council, instituted penicillin treatment for all soldiers with early or latent syphilis. The schedule

REFERENCES

Sternberg, T. H., and Leifer, W.:  The Treatment of Early Syphilis by the Twenty-Six Weeks Mapharsen-Bismuth Schedule , Am.J.Syph., Gonor. & Ven. Dis. , to be published.
Mahoney, J. F.; Arnold, R. C., and Harris, A.:  Penicillin Treatment of Early Syphilis , Am. J. Pub. Health 33:1387 ( (Dec.) ) 1943;.
Moore, J. E.; Mahoney, J. F.; Schwartz, W. H.; Sternberg, T. H., and Wood, W. B.:  The Treatment of Early Syphilis with Penicillin , J. A. M. A. 126:67 ( (Sept. 9) ) 1944;.
Leifer, W.:  The Treatment of Early Syphilis with Penicillin , J. A. M. A. 129:1247 ( (Dec. 29) ) 1945;.
Grauer, F. H.: Unpublished data.
Management of Syphilis, U. S. War Department Technical Bulletin (TB Med. 106), Washington, D. C., Government Printing Office, Oct. 11, 1944.
Moore, J. E.: The Modern Treatment of Syphilis , ed. 2, Springfield, Ill., Charles C Thomas, Publisher, 1941;, p. 346.
Sternberg and Leifer.1 Wise, C. R., and Pillsbury, D. M.:  Penicillin in the Treatment of Syphilis , Proc. Roy. Soc. Med. 37:491 ( (July) ) 1944;.
Pillsbury, D. M.:  Penicillin Therapy in Early Syphilis , Brit. J. Ven. Dis. 21: 139 ( (Dec.) ) 1945;.
 Official Statement on Penicillin in Syphilis , J. A. M. A. 131:34 ( (May 4) ) 1946;.
Eagle, H., and Musselman, A.:  The Low Therapeutic Activity of Penicillin K Relative to That of Penicillins F, G, and X, and Its Pharmacological Basis , Science 103:618 ( (May 17) ) 1946;.
Schoch, A. G., and Alexander, L. J.:  Reinfection in Syphilis , Am. J. Syph., Gonor. & Ven. Dis. 27: 15 ( (Jan.) ) 1943;.
Beerman, H.:  The Problem of Reinoculation of Human Beings with Spirochaeta Pallida , Am. J. Syph., Gonor. & Ven. Dis. 30: 173 ( (March) ) 1946;.
Stokes, J. H.; Beerman, H., and Ingraham, N. R., Jr.: Modern Clinical Syphilology , ed. 3, Philadelphia, W. B. Saunders Company, 1944;, pp. 186-188 and 645-647.

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Sternberg, T. H., and Leifer, W.:  The Treatment of Early Syphilis by the Twenty-Six Weeks Mapharsen-Bismuth Schedule , Am.J.Syph., Gonor. & Ven. Dis. , to be published.
Mahoney, J. F.; Arnold, R. C., and Harris, A.:  Penicillin Treatment of Early Syphilis , Am. J. Pub. Health 33:1387 ( (Dec.) ) 1943;.
Moore, J. E.; Mahoney, J. F.; Schwartz, W. H.; Sternberg, T. H., and Wood, W. B.:  The Treatment of Early Syphilis with Penicillin , J. A. M. A. 126:67 ( (Sept. 9) ) 1944;.
Leifer, W.:  The Treatment of Early Syphilis with Penicillin , J. A. M. A. 129:1247 ( (Dec. 29) ) 1945;.
Grauer, F. H.: Unpublished data.
Management of Syphilis, U. S. War Department Technical Bulletin (TB Med. 106), Washington, D. C., Government Printing Office, Oct. 11, 1944.
Moore, J. E.: The Modern Treatment of Syphilis , ed. 2, Springfield, Ill., Charles C Thomas, Publisher, 1941;, p. 346.
Sternberg and Leifer.1 Wise, C. R., and Pillsbury, D. M.:  Penicillin in the Treatment of Syphilis , Proc. Roy. Soc. Med. 37:491 ( (July) ) 1944;.
Pillsbury, D. M.:  Penicillin Therapy in Early Syphilis , Brit. J. Ven. Dis. 21: 139 ( (Dec.) ) 1945;.
 Official Statement on Penicillin in Syphilis , J. A. M. A. 131:34 ( (May 4) ) 1946;.
Eagle, H., and Musselman, A.:  The Low Therapeutic Activity of Penicillin K Relative to That of Penicillins F, G, and X, and Its Pharmacological Basis , Science 103:618 ( (May 17) ) 1946;.
Schoch, A. G., and Alexander, L. J.:  Reinfection in Syphilis , Am. J. Syph., Gonor. & Ven. Dis. 27: 15 ( (Jan.) ) 1943;.
Beerman, H.:  The Problem of Reinoculation of Human Beings with Spirochaeta Pallida , Am. J. Syph., Gonor. & Ven. Dis. 30: 173 ( (March) ) 1946;.
Stokes, J. H.; Beerman, H., and Ingraham, N. R., Jr.: Modern Clinical Syphilology , ed. 3, Philadelphia, W. B. Saunders Company, 1944;, pp. 186-188 and 645-647.
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