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September 21, 1946, Vol 132, No. 3 >
ARTICLE | September 21, 1946

NITROGEN MUSTARD THERAPY: Title and subTitle BreakUse of Methyl-Bis(Beta-Chloroethyl)amine Hydrochloride and Tris(Beta-Chloroethyl)amine Hydrochloride for Hodgkin's Disease, Lymphosarcoma, Leukemia and Certain Allied and Miscellaneous Disorders FREE

LOUIS S. GOODMAN, M.D.; MAXWELL M. WINTROBE, M.D.; WILLIAM DAMESHEK, M.D.; MORTON J. GOODMAN, M.D.MAJOR ; ALFRED GILMAN; MARGARET T. McLENNAN, M.D.
[+] Author Affiliations

The Jane Coffin Childs Fund for Medical Research, Yale University, defrayed part of the expenses of this investigation.

The chemicals employed in this study were generously supplied by Dr. Milton C. Winternitz, Chairman, Committee on the Treatment of Gas Casualties.

Reports of several of the investigations referred to either have not been published or have not been recorded in the open literature. The date given is the year in which the work was carried out.

The following physicians have generously cooperated in providing cases for study: Drs. Gustaf E. Lindskog, Grover F. Powers, Francis G. Blake, G. G. Richards, M. J. Taylor and L. A. Wheelwright.


Salt Lake City; Salt Lake City; Boston; Portland, Ore.; Medical Corps, Army of the United States; Salt Lake City

Dr. L. S. Goodman, Dr. Wintrobe and Dr. McLennan are from the University of Utah School of Medicine; Dr. Dameshek is from Tufts College Medical School; Dr. Morton J. Goodman is from the University of Oregon Medical School, and Major Gilman is from the Medical Research Division, Edgewood Arsenal.


JAMA. 1946;132(3):126-132. doi:10.1001/jama.1946.02870380008004
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References

In a recent report the historical aspects of the use of β-chloroethyl amines (halogenated alkyl amines, nitrogen mustards) in the treatment of certain diseases of the blood-forming organs were presented and the chemical, pharmacologic, toxicologic and animal experimental aspects of these compounds reviewed.1 The interested reader is referred to that report for orientation.

The present preliminary communication concerns the clinical use of halogenated alkyl amines in the treatment of lymphosarcoma, Hodgkin's disease, leukemia and a limited number of allied and miscellaneous disorders. In all, 67 patients have been studied. These include 7 patients2 treated by L. S. Goodman and Alfred Gilman at the New Haven Hospital; 34 patients treated by M. M. Wintrobe and Margaret T. McLennan at the Salt Lake County General Hospital; 16 patients treated by William Dameshek, Boston, and 10 patients treated by M. J. Goodman, Portland, Ore. The types of diseases treated are shown

REFERENCES

1 +
Gilman, A., and Philips, F. S.:  The Biological Actions and Therapeutic Applications of the B-Chloroethyl Amines and Sulfides , Science 103: 409-415, 1946;.
2 +
Gilman, A.; Goodman, L. S.; Philips, F. S., and Dougherty, T., 1943.
3 +
Dougherty, T.; Gilman, A., and Goodman, L. S., 1942. Unpublished observations.
4 +
Dr. Gustaf E. Lindskog, Department of Surgery, Yale University School of Medicine, gave the authors permission to study and report this case.
5 +
A complete description of this case has appeared elsewhere.2
6 +
Duran-Reynals, F.; Goodman, L. S., and Gilman, A., 1942. Unpublished observations.2

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1 +
Gilman, A., and Philips, F. S.:  The Biological Actions and Therapeutic Applications of the B-Chloroethyl Amines and Sulfides , Science 103: 409-415, 1946;.
2 +
Gilman, A.; Goodman, L. S.; Philips, F. S., and Dougherty, T., 1943.
3 +
Dougherty, T.; Gilman, A., and Goodman, L. S., 1942. Unpublished observations.
4 +
Dr. Gustaf E. Lindskog, Department of Surgery, Yale University School of Medicine, gave the authors permission to study and report this case.
5 +
A complete description of this case has appeared elsewhere.2
6 +
Duran-Reynals, F.; Goodman, L. S., and Gilman, A., 1942. Unpublished observations.2

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