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PENICILLIN X: Title and subTitle BreakSUCCESSFUL TREATMENT OF GONORRHEA WITH A SINGLE INTRAMUSCULAR INJECTION

HENRY WELCH, Ph.D.; LAWRENCE E. PUTNAM, M.D.; WILLIAM A. RANDALL, Ph.D.; ROBERT P. HERWICK, M.D., Ph.D.
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WASHINGTON, D. C.


JAMA. 1944;126(16):1024-1024. doi:10.1001/jama.1944.02850510032007
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In a recent issue of Science1 it was reported that gonorrhea had been successfully treated with single injections of 100,000 units of commercial penicillin incorporated in a beeswax-peanut oil base. For the past several months we have had an opportunity to investigate the properties of so-called penicillin X,2 sometimes referred to as factor X, or allopenicillin. This material was furnished to us by three manufacturers.3 A small amount of crystalline penicillin X4 was also made available to us.

When assayed by the cup-plate method5 the potency of crystalline penicillin X is approximately 900 units per milligram, while crystalline penicillin6 has a potency of 1,650 units per milligram. In addition, in vitro studies (serial dilution) show that penicillin X is more effective than commercial penicillin against a strain of Klebsiella pneumoniae type A and a strain of Bacillus cereus. No difference in effect could be

REFERENCES

Since this report was submitted for publication, 5 additional pneumonectomies have been performed in accordance with the procedure outlined in this study. All 5 patients received the prophylactic course of penicillin. Four of them were resected for bronchiogenic carcinoma and 1 for a bronchial adenoma. None of these patients became infected and all of them survived.
Romansky, M. J., and Rittman, G. E.:  A Method of Prolonging the Action of Penicillin , Science 100:196, 1944;.
Commercial penicillin and penicillin X in this article refer to the sodium salts of these substances.
Obtained through the courtesy of the Upjohn Company, Cutter Laboratories and Cheplin Biological Laboratories.
Robert D. Coghill of the Northern Regional Research Laboratory supplied the crystalline penicillin X.
Mimeograph: "Methods Used by the Food and Drug Administration for the Assay of Penicillin, January 1944."
Crystalline penicillin G prepared from commercial penicillin.
The clinical work in this study was done at the Rapid Treatment Center, Gallinger Municipal Hospital, Washington, D. C. Drs. Sidney Olansky, A. M. Gamboa and M. L. Cannon aided in these studies.

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Since this report was submitted for publication, 5 additional pneumonectomies have been performed in accordance with the procedure outlined in this study. All 5 patients received the prophylactic course of penicillin. Four of them were resected for bronchiogenic carcinoma and 1 for a bronchial adenoma. None of these patients became infected and all of them survived.
Romansky, M. J., and Rittman, G. E.:  A Method of Prolonging the Action of Penicillin , Science 100:196, 1944;.
Commercial penicillin and penicillin X in this article refer to the sodium salts of these substances.
Obtained through the courtesy of the Upjohn Company, Cutter Laboratories and Cheplin Biological Laboratories.
Robert D. Coghill of the Northern Regional Research Laboratory supplied the crystalline penicillin X.
Mimeograph: "Methods Used by the Food and Drug Administration for the Assay of Penicillin, January 1944."
Crystalline penicillin G prepared from commercial penicillin.
The clinical work in this study was done at the Rapid Treatment Center, Gallinger Municipal Hospital, Washington, D. C. Drs. Sidney Olansky, A. M. Gamboa and M. L. Cannon aided in these studies.
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