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ARTICLE |

SULFADIAZINE IN THE TREATMENT OF THE COMMON COLD FREE

RUSSELL L. CECIL, M.D.MAJOR ; NORMAN PLUMMER; WILSON G. SMILLIE, M.D.
[+] Author Affiliations

NEW YORK; MEDICAL CORPS, ARMY OF THE UNITED STATES; NEW YORK

From the Medical Service of the New York Hospital and the Departments of Medicine and Public Health and Preventive Medicine of Cornell University Medical College.


JAMA. 1944;124(1):8-14. doi:10.1001/jama.1944.02850010010003
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The common cold derives its medical importance chiefly from the fact that it is followed so frequently by secondary infection. The uncomplicated cold, now generally accepted as caused by a filtrable virus, runs a mild course, usually afebrile, and clears up completely in four to seven days. On the other hand, a cold complicated by a secondary bacterial infection which may involve the sinuses, middle ear, mastoids, larynx or lungs can lead to a fatal outcome. It is evident, therefore, that the cold problem would be greatly simplified if all colds could be retained in the uncomplicated form by some relatively harmless medication. The value that sulfadiazine, the least toxic of the sulfonamides, might have in this role is the consideration of this study.

It is generally agreed that the sulfonamides have little or no effect on the virus initiating the common cold, but it has been accepted that they

REFERENCES

Long, P. H., and Bliss, Eleanor A.:  Para-Aminobenzenesulfonamide and Its Derivatives: Clinical Observations on Their Use in the Treatment of Infections Due to Beta Hemolytic Streptococci , Arch. Surg. 34:351 ( (Feb.) ) 1937;.
Rhoads, P. S., and Afremow, N. S.  Sulfanilamide in Treatment of Sore Throat Due to Hemolytic Streptococci , J. A. M. A. 114:942 ( (March 16) ) 1940;.
Kernan, J. D.:  Infections of the Mouth, Pharynx and Upper Respiratory Tract , Bull. New York Acad. Med. 17:674 ( (Sept.) ) 1941;.
Turnbull, F. M.:  Intranasal Therapy with Sodium Salt of Sulfathiazole in Chronic Sinusitis , J. A. M. A. 116: 1899 ( (April 26) ) 1941;.
Gundrum, L. K.:  Effect of the Newer Sulfanilamide Derivatives on the Nasal Mucosa of Rabbits , Arch. Otolaryng. 37:209 ( (Feb.) ) 1943;.
Bowers, W. C.:  Infections of the Middle Ear and Nasal Sinuses , Preventive Medicine in Modern Practice (edited under the auspices of the Committee on Public Health Relations, New York Acad. Med.), p. 525, New York, Paul B. Hoeber, Inc., 1942;.
Silcox, L. E., and Schenk, H. P.:  Use in Otolaryngology of Microcrystals of Drugs of the Sulfanilamide Group , Arch. Otolaryng. 36: 171 ( (Aug.) ) 1942;.
Bordley, J. E.; Crowe, S. J.; Dolowitz, D. A., and Pickrell, K. L.:  The Local Use of the Sulfonamides, Gramicidin (Tyrothricin) and Penicillin in Otolaryngology , Ann. Otol., Rhin. & Laryng. 51:936 ( (Dec.) ) 1942;.
Rusk, H. A., and van Ravenswaay, A. C.:  Sulfadiazine in Respiratory Tract Infections: Its Value in Treatment During Winter of 1942-1943 at Jefferson Barracks, Missouri , J. A. M. A. 122:495 ( (June 19) ) 1943;.
Siegel, Morris:  Studies on Control of Acute Infections of Respiratory Tract: Oral Administration of Sulfadiazine at the Onset of Acute Respiratory Illnesses , Am. J. Dis. Child. 66:114 ( (Aug.) ) 1943;.
Our subjects were directed to us through the courtesy and cooperation of Dr. Marian Tyndall of the Nurses Health Service and Dr. Frank M. Falconer of the Hospital Personnel Clinic.
These examinations were made by Dr. James A. Moore of the Department of Otolaryngology.
Bratton, A. C., and Marshall, E. K., Jr.:  A New Coupling Component for Sulfanilamide Determination , J. Biol. Chem. 128:537 ( (May) ) 1939;.
Burky, E. L., and Smillie, W. G.:  Nasopharyngeal Flora in Health and During Respiratory Disease in Isolated Communities in Alabama and Labrador , J. Exper. Med. 50:643 ( (Nov.) ) 1929;.
Plummer, Norman, and Wheeler, Charles:  The Toxicity of Sulfadiazine: Observations on 1,357 Cases , Am. J. M. Sc. , to be published.
Merkel, W. C., and Crawford, R. C.:  Pathologic Lesions Produced by Sulfathiazole: Report of Four Fatal Cases , J. A. M. A. 119:770 ( (July 4) ) 1942;.
Maisel, Bernard; McSwain, Barton, and Glenn, Frank:  Effects of Administration of Sodium Sulfadiazine to Dogs , Arch. Surg. 46:326 ( (March) ) 1943;.
Tillett, W. S.; Cambier, M. J., and Harris, W. H., Jr.:  Sulfonamide-Fast Pneumococci: Clinical Report of Two Cases of Pneumonia Together with Experimental Studies on Effectiveness of Penicillin and Tyrothricin Against Sulfonamide Resistant Strains , J. Clin. Investigation 22:249 ( (March) ) 1943;.
Longcope, W. T.:  Serum Sickness and Analogous Reactions from Certain Drugs, Particularly the Sulfonamides , Medicine 22:251 ( (Sept.) ) 1943;.

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Long, P. H., and Bliss, Eleanor A.:  Para-Aminobenzenesulfonamide and Its Derivatives: Clinical Observations on Their Use in the Treatment of Infections Due to Beta Hemolytic Streptococci , Arch. Surg. 34:351 ( (Feb.) ) 1937;.
Rhoads, P. S., and Afremow, N. S.  Sulfanilamide in Treatment of Sore Throat Due to Hemolytic Streptococci , J. A. M. A. 114:942 ( (March 16) ) 1940;.
Kernan, J. D.:  Infections of the Mouth, Pharynx and Upper Respiratory Tract , Bull. New York Acad. Med. 17:674 ( (Sept.) ) 1941;.
Turnbull, F. M.:  Intranasal Therapy with Sodium Salt of Sulfathiazole in Chronic Sinusitis , J. A. M. A. 116: 1899 ( (April 26) ) 1941;.
Gundrum, L. K.:  Effect of the Newer Sulfanilamide Derivatives on the Nasal Mucosa of Rabbits , Arch. Otolaryng. 37:209 ( (Feb.) ) 1943;.
Bowers, W. C.:  Infections of the Middle Ear and Nasal Sinuses , Preventive Medicine in Modern Practice (edited under the auspices of the Committee on Public Health Relations, New York Acad. Med.), p. 525, New York, Paul B. Hoeber, Inc., 1942;.
Silcox, L. E., and Schenk, H. P.:  Use in Otolaryngology of Microcrystals of Drugs of the Sulfanilamide Group , Arch. Otolaryng. 36: 171 ( (Aug.) ) 1942;.
Bordley, J. E.; Crowe, S. J.; Dolowitz, D. A., and Pickrell, K. L.:  The Local Use of the Sulfonamides, Gramicidin (Tyrothricin) and Penicillin in Otolaryngology , Ann. Otol., Rhin. & Laryng. 51:936 ( (Dec.) ) 1942;.
Rusk, H. A., and van Ravenswaay, A. C.:  Sulfadiazine in Respiratory Tract Infections: Its Value in Treatment During Winter of 1942-1943 at Jefferson Barracks, Missouri , J. A. M. A. 122:495 ( (June 19) ) 1943;.
Siegel, Morris:  Studies on Control of Acute Infections of Respiratory Tract: Oral Administration of Sulfadiazine at the Onset of Acute Respiratory Illnesses , Am. J. Dis. Child. 66:114 ( (Aug.) ) 1943;.
Our subjects were directed to us through the courtesy and cooperation of Dr. Marian Tyndall of the Nurses Health Service and Dr. Frank M. Falconer of the Hospital Personnel Clinic.
These examinations were made by Dr. James A. Moore of the Department of Otolaryngology.
Bratton, A. C., and Marshall, E. K., Jr.:  A New Coupling Component for Sulfanilamide Determination , J. Biol. Chem. 128:537 ( (May) ) 1939;.
Burky, E. L., and Smillie, W. G.:  Nasopharyngeal Flora in Health and During Respiratory Disease in Isolated Communities in Alabama and Labrador , J. Exper. Med. 50:643 ( (Nov.) ) 1929;.
Plummer, Norman, and Wheeler, Charles:  The Toxicity of Sulfadiazine: Observations on 1,357 Cases , Am. J. M. Sc. , to be published.
Merkel, W. C., and Crawford, R. C.:  Pathologic Lesions Produced by Sulfathiazole: Report of Four Fatal Cases , J. A. M. A. 119:770 ( (July 4) ) 1942;.
Maisel, Bernard; McSwain, Barton, and Glenn, Frank:  Effects of Administration of Sodium Sulfadiazine to Dogs , Arch. Surg. 46:326 ( (March) ) 1943;.
Tillett, W. S.; Cambier, M. J., and Harris, W. H., Jr.:  Sulfonamide-Fast Pneumococci: Clinical Report of Two Cases of Pneumonia Together with Experimental Studies on Effectiveness of Penicillin and Tyrothricin Against Sulfonamide Resistant Strains , J. Clin. Investigation 22:249 ( (March) ) 1943;.
Longcope, W. T.:  Serum Sickness and Analogous Reactions from Certain Drugs, Particularly the Sulfonamides , Medicine 22:251 ( (Sept.) ) 1943;.
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