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March 11, 1944, Vol 124, No. 11 >
Other Articles | March 11, 1944

INSULINS AND INSULIN MODIFIERS: Title and subTitle BreakINTRADERMAL STUDIES

Robert L. Page, M.D.; Louis Bauman, M.D.
[+] Author Affiliations

Dr. Franklin Stevens of the allergy clinic cooperated in this study, and Miss Agnes Shuford, R.N., performed the cutaneous tests.


New York

From the Department of Medicine, Presbyterian Hospital and Columbia University.


JAMA. 1944;124(11):704-705. doi:10.1001/jama.1944.62850110002008a
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References

In their respective textbooks Joslin,1 Wilder2 and Duncan3 have stated that injections of protamine zinc insulin are more apt to produce cutaneous reactions than regular insulin. During an experience of seven years we have found that globin insulin (with zinc) has only rarely been followed by cutaneous reactions. Bauman4 found that several patients who had severe skin reactions after injections of protamine zinc insulin obtained immediate relief when globin insulin (with zinc) was substituted. Duncan5 replaced protamine zinc insulin with globin insulin (with zinc) in 2 patients and noted a disappearance of the irritation of the skin. In the article published by Bailey and Marble6 local reactions were not encountered when globin insulin (with zinc) was used.

As the question of sensitivity to insulin is of some practical importance and because we wanted to see if the results of cutaneous tests with uncombined protamine

REFERENCES

1 +
Joslin, E. P.: Treatment of Diabetes Mellitus , Philadelphia, Lea & Febiger, 1940;.
2 +
Wilder, R. M.: Clinical Diabetes Mellitus and Hyperinsulinism , Philadelphia, W. B. Saunders Company, 1940;.
3 +
Duncan, G. G.: Diseases of Metabolism , Philadelphia, W. B. Saunders Company, 1942;.
4 +
Bauman, L.:  Clinical Experience with Globin Insulin , Am. J. M. Sc. 198:475, 1939;
5 +
 Further Experience with Globin Insulin , BaumanAm. J. M. Sc. 200:299, 1940;.
6 +
Duncan, G. G.:  The Action of Globin Insulin Compared with That of Crystalline, Unmodified and Protamine Zinc Insulin , Am. J. M. Sc. 202:553, 1941;.
7 +
Bailey, C. C., and Marble, A.:  Histone Zinc Insulin, Globin (Zinc) Insulin and Clear Protamine Zinc Insulin , J. A. M. A. 118:683 ( (Feb. 28) ) 1942;.
8 +
Bauman, L.:  Is Globin a Histone? J. A. M. A. 116:2336 ( (May 17) ) 1941;.
9 +
Anson, M. L., and Mirsky, A. E.:  Protein Coagulation and Its Reversal: Preparation of Insoluble Globin, Soluble Globin and Heme , J. Gen. Physiol. 13:469, 1930;.
10 +
Reiner, L.; Searle, D. S., and Lang, E. H.:  On the Hypoglycemic Activity of Globin Insulin , J. Pharmacol. & Exper. Therap. 67:330, 1939;.
11 +
Information supplied by E. R. Squibb & Sons.
12 +
Scott, D. A., and Fisher, A. M.:  CXXXI. Crystalline Insulin , Biochem. J. 29:1048, 1935;.
13 +
New and Nonofficial Remedies , Chicago, American Medical Association Press, 1941;.
14 +
Kern, R. A., and Langner, R. H., Jr.:  Protamine and Allergy , J. A. M. A. 113:198 ( (July 15) ) 1939;.
15 +
Reiner, L., and Lang, E. H.:  Insulin Azo Derivatives , J. Biol. Chem. 139:64, 1941;.
16 +
Lang, E. H., and Reiner, L.:  Crystalline Insulin Derivatives , Science 93:401, 1941;.
17 +
Reiner, L.; deBeer, E. J., and Green, M.:  Toxic Effects of Some Basic Proteins , Proc. Soc. Exper. Biol. & Med. 50:70, 1942;.

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1 +
Joslin, E. P.: Treatment of Diabetes Mellitus , Philadelphia, Lea & Febiger, 1940;.
2 +
Wilder, R. M.: Clinical Diabetes Mellitus and Hyperinsulinism , Philadelphia, W. B. Saunders Company, 1940;.
3 +
Duncan, G. G.: Diseases of Metabolism , Philadelphia, W. B. Saunders Company, 1942;.
4 +
Bauman, L.:  Clinical Experience with Globin Insulin , Am. J. M. Sc. 198:475, 1939;
5 +
 Further Experience with Globin Insulin , BaumanAm. J. M. Sc. 200:299, 1940;.
6 +
Duncan, G. G.:  The Action of Globin Insulin Compared with That of Crystalline, Unmodified and Protamine Zinc Insulin , Am. J. M. Sc. 202:553, 1941;.
7 +
Bailey, C. C., and Marble, A.:  Histone Zinc Insulin, Globin (Zinc) Insulin and Clear Protamine Zinc Insulin , J. A. M. A. 118:683 ( (Feb. 28) ) 1942;.
8 +
Bauman, L.:  Is Globin a Histone? J. A. M. A. 116:2336 ( (May 17) ) 1941;.
9 +
Anson, M. L., and Mirsky, A. E.:  Protein Coagulation and Its Reversal: Preparation of Insoluble Globin, Soluble Globin and Heme , J. Gen. Physiol. 13:469, 1930;.
10 +
Reiner, L.; Searle, D. S., and Lang, E. H.:  On the Hypoglycemic Activity of Globin Insulin , J. Pharmacol. & Exper. Therap. 67:330, 1939;.
11 +
Information supplied by E. R. Squibb & Sons.
12 +
Scott, D. A., and Fisher, A. M.:  CXXXI. Crystalline Insulin , Biochem. J. 29:1048, 1935;.
13 +
New and Nonofficial Remedies , Chicago, American Medical Association Press, 1941;.
14 +
Kern, R. A., and Langner, R. H., Jr.:  Protamine and Allergy , J. A. M. A. 113:198 ( (July 15) ) 1939;.
15 +
Reiner, L., and Lang, E. H.:  Insulin Azo Derivatives , J. Biol. Chem. 139:64, 1941;.
16 +
Lang, E. H., and Reiner, L.:  Crystalline Insulin Derivatives , Science 93:401, 1941;.
17 +
Reiner, L.; deBeer, E. J., and Green, M.:  Toxic Effects of Some Basic Proteins , Proc. Soc. Exper. Biol. & Med. 50:70, 1942;.

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