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MENINGOENCEPHALITIS IN MAN CAUSED BY THE VIRUS OF LYMPHOGRANULOMA VENEREUM FREE

ALBERT B. SABIN, M.D.; CHARLES D. ARING, M.D.
[+] Author Affiliations

CINCINNATI

From the Children's Hospital Research Foundation and the Departments of Pediatrics and Internal Medicine (Neurology) of the University of Cincinnati College of Medicine.


JAMA. 1942;120(17):1376-1381. doi:10.1001/jama.1942.02830520026008
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Our purpose in this communication is to present data establishing the virus of lymphogranuloma venereum as a cause of severe meningoencephalitis in man. The capacity of the causative agent of venereal lymphogranuloma (lymphogranuloma inguinale, lymphopathia venerea, Nicolas-Favre disease, climatic bubo, fourth venereal disease) to produce meningoencephalitis after intracerebral inoculation in susceptible experimental animals has been known since the virus was first isolated and identified in 1930.1 However, even in experimental animals meningoencephalitis was not known to occur after inoculation of the virus by peripheral routes without simultaneous trauma to the brain.2 Signs and symptoms suggestive of involvement of the nervous system during the course of lymphogranuloma venereum in man have been recorded by many observers.3 Von Haam and D'Aunoy4 isolated from the cerebrospinal fluid of 2 out of 8 patients with lymphogranuloma venereum viruses which produced meningoencephalitis in mice. These viruses were identified as lymphogranuloma venereum

REFERENCES

Hellerström, S., and Wassén, E.:  Meningo-enzephalitische Veränderungen bei Affen nach intracerebraler Impfung mit Lymphogranuloma inguinale , Proc. 8th Internat. Congr. Dermat. & Syph., 1930 , p. 1147.
Levaditi, Constantin; Ravaut, P., and Schoen, R.:  Récéptivité de la souris à l'égard du virus de la maladie de Nicolas et Favre , Compt. rend. Soc. de biol. 109:285 ( (Feb. 5) ) 1932;.
Findlay, G. M.:  The Relationship of Climatic Bubo and Lymphogranuloma Inguinale , Lancet 2:11 ( (July 2) ) 1932;
 Experiments on the Transmission of the Virus of Climatic Bubo (Lymphogranuloma Inguinale) to Animals , Tr. Roy. Soc. Trop. Med. & Hyg. 27:35 ( (June) ) 1933;.
D'Aunoy, Rigney, and von Haam, Emmerich:  Venereal Lymphogranuloma , Arch. Path. 27: 1032 ( (June) ) 1939;.
Lévy-Valensi, J., and de Séze, S.:  Sur les complications nerveuses au cours de la maladie de Nicolas-Favre , Presse méd. 47: 593 ( (April 19) ) 1939;.
Midana, A., and Vercellino, L.:  Les altérations du systéme nerveux central de l'homme dans la poradénite inguinale , Bull. Soc. franç. de dermat. et syph. 41: 161 ( (Feb.) ) 1934;.
Coutts, W. E.:  Lymphogranuloma Inguinale as a General Disease , J. Trop. Med. & Hyg. 39: 13 ( (Jan. 15) ) 1936;.
David, V. C., and Loring, Mark:  Extragenital Lesions of Lymphogranuloma Inguinale , J. A. M. A. 106: 1875 ( (May 30) ) 1936;.
Koschucharoff, B.:  Ueber das Vorkommen einer Infektion des Zentralnervensystems beim Lymphogranuloma inguinale , Klin. Wchnschr. 17: 876 ( (June 18) ) 1938;.
von Haam, Emmerich, and D'Aunoy, Rigney:  Infectivity of the Spinal Fluid in Lymphogranuloma Inguinale , J. A. M. A. 106: 1642 ( (May 9) ) 1936;.
von Haam, Emmerich: Personal communication to the authors.
Wilson, J. F.:  Genital Warts , J. Roy. Army. M. Corps 68:227 ( (April) ), 305 (May) 1937;.
Rake, Geoffrey; Eaton, M. D., and Shaffer, M. F.:  Similarities and Possible Relationships Among Viruses of Psittacosis, Meningopneumonitis and Lymphogranuloma Venereum , Proc. Soc. Exper. Biol. & Med. 48: 528 ( (Nov.) ) 1941;.
Eaton, M. D.; Martin, W. P., and Beck, M. D.:  The Antigenic Relationship of the Viruses of Meningopneumonitis and Lymphogranuloma Venereum , J. Exper. Med. 75:21 ( (Jan.) ) 1942;.
Francis, T., Jr., and Magill, T. P.:  An Unidentified Virus Producing Acute Meningitis and Pneumonitis in Experimental Animals , J. Exper. Med. 68:147 ( (Aug.) ) 1938;.
Eaton, M. D.; Beck, M. D., and Pearson, H. E.:  A Virus from Cases of Atypical Pneumonia: Relation to the Viruses of Meningopneumonitis and Psittacosis , J. Exper. Med. 73:641 ( (May) ) 1941;.
McKee, Clara M.; Rake, Geoffrey, and Shaffer, M. F.:  Complement Fixation Test in Lymphogranuloma Venereum , Proc. Soc. Exper. Biol. & Med. 44: 410 ( (June) ) 1940;.
Rajam, R. V.:  Report of a Fatal Case of Lymphogranuloma Inguinale from Meningoencephalitis , Brit. J. Ven. Dis. 12:237 ( (Oct.) ) 1936;.
Rake, Geoffrey; Shaffer, M. F.; Grace, A. W.; McKee, Clara M., and Jones, H. P.:  New Aids in the Diagnosis of Lymphogranuloma Venereum , Am. J. Syph., Gonor. & Ven. Dis. 25:687 ( (Nov.) ) 1941;.
Rake, Geoffrey; McKee, Clara M., and Shaffer, M. F.:  Agent of Lymphogranuloma Venereum in the Yolk-Sac of the Developing Chick Embryo , Proc. Soc. Exper. Biol. & Med. 43: 332 ( (Feb.) ) 1940;.

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Hellerström, S., and Wassén, E.:  Meningo-enzephalitische Veränderungen bei Affen nach intracerebraler Impfung mit Lymphogranuloma inguinale , Proc. 8th Internat. Congr. Dermat. & Syph., 1930 , p. 1147.
Levaditi, Constantin; Ravaut, P., and Schoen, R.:  Récéptivité de la souris à l'égard du virus de la maladie de Nicolas et Favre , Compt. rend. Soc. de biol. 109:285 ( (Feb. 5) ) 1932;.
Findlay, G. M.:  The Relationship of Climatic Bubo and Lymphogranuloma Inguinale , Lancet 2:11 ( (July 2) ) 1932;
 Experiments on the Transmission of the Virus of Climatic Bubo (Lymphogranuloma Inguinale) to Animals , Tr. Roy. Soc. Trop. Med. & Hyg. 27:35 ( (June) ) 1933;.
D'Aunoy, Rigney, and von Haam, Emmerich:  Venereal Lymphogranuloma , Arch. Path. 27: 1032 ( (June) ) 1939;.
Lévy-Valensi, J., and de Séze, S.:  Sur les complications nerveuses au cours de la maladie de Nicolas-Favre , Presse méd. 47: 593 ( (April 19) ) 1939;.
Midana, A., and Vercellino, L.:  Les altérations du systéme nerveux central de l'homme dans la poradénite inguinale , Bull. Soc. franç. de dermat. et syph. 41: 161 ( (Feb.) ) 1934;.
Coutts, W. E.:  Lymphogranuloma Inguinale as a General Disease , J. Trop. Med. & Hyg. 39: 13 ( (Jan. 15) ) 1936;.
David, V. C., and Loring, Mark:  Extragenital Lesions of Lymphogranuloma Inguinale , J. A. M. A. 106: 1875 ( (May 30) ) 1936;.
Koschucharoff, B.:  Ueber das Vorkommen einer Infektion des Zentralnervensystems beim Lymphogranuloma inguinale , Klin. Wchnschr. 17: 876 ( (June 18) ) 1938;.
von Haam, Emmerich, and D'Aunoy, Rigney:  Infectivity of the Spinal Fluid in Lymphogranuloma Inguinale , J. A. M. A. 106: 1642 ( (May 9) ) 1936;.
von Haam, Emmerich: Personal communication to the authors.
Wilson, J. F.:  Genital Warts , J. Roy. Army. M. Corps 68:227 ( (April) ), 305 (May) 1937;.
Rake, Geoffrey; Eaton, M. D., and Shaffer, M. F.:  Similarities and Possible Relationships Among Viruses of Psittacosis, Meningopneumonitis and Lymphogranuloma Venereum , Proc. Soc. Exper. Biol. & Med. 48: 528 ( (Nov.) ) 1941;.
Eaton, M. D.; Martin, W. P., and Beck, M. D.:  The Antigenic Relationship of the Viruses of Meningopneumonitis and Lymphogranuloma Venereum , J. Exper. Med. 75:21 ( (Jan.) ) 1942;.
Francis, T., Jr., and Magill, T. P.:  An Unidentified Virus Producing Acute Meningitis and Pneumonitis in Experimental Animals , J. Exper. Med. 68:147 ( (Aug.) ) 1938;.
Eaton, M. D.; Beck, M. D., and Pearson, H. E.:  A Virus from Cases of Atypical Pneumonia: Relation to the Viruses of Meningopneumonitis and Psittacosis , J. Exper. Med. 73:641 ( (May) ) 1941;.
McKee, Clara M.; Rake, Geoffrey, and Shaffer, M. F.:  Complement Fixation Test in Lymphogranuloma Venereum , Proc. Soc. Exper. Biol. & Med. 44: 410 ( (June) ) 1940;.
Rajam, R. V.:  Report of a Fatal Case of Lymphogranuloma Inguinale from Meningoencephalitis , Brit. J. Ven. Dis. 12:237 ( (Oct.) ) 1936;.
Rake, Geoffrey; Shaffer, M. F.; Grace, A. W.; McKee, Clara M., and Jones, H. P.:  New Aids in the Diagnosis of Lymphogranuloma Venereum , Am. J. Syph., Gonor. & Ven. Dis. 25:687 ( (Nov.) ) 1941;.
Rake, Geoffrey; McKee, Clara M., and Shaffer, M. F.:  Agent of Lymphogranuloma Venereum in the Yolk-Sac of the Developing Chick Embryo , Proc. Soc. Exper. Biol. & Med. 43: 332 ( (Feb.) ) 1940;.
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