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HANDBOOK OF NUTRITION: IX: Title and subTitle BreakTHE TRACE ELEMENTS IN NUTRITION FREE

MAURICE E. SHILS, Sc.D.; E. V. McCOLLUM, PH.D., Sc.D.
JAMA. 1942;120(8):609-619. doi:10.1001/jama.1942.82830430003010
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The many mineral elements which exist in animal tissues occur in widely varying amounts. They range from calcium, which comprises approximately 2 per cent of the adult human body weight and which can be expressed in kilograms, down to those which we must measure in milligrams and even micrograms, and which have been termed "trace elements." The dividing line between trace and non-trace elements is purely arbitrary and a matter of choice. Some nutritionists1 include in the former category any element occurring in the tissues or nutritionally necessary in amounts equal to and less than iron, but others2 consider only those elements below iron.

Presaging the point of view that traces of minerals might exert profound and specialized physiologic effects were the discoveries that iodine occurs in the thyroid,3 copper in octopus blood4 and in the hemocyanin of crustacea,5 zinc in the hemosycotopin of oysters,6

REFERENCES

McCollum, E. V.; Orent-Keiles, E., and Day, H. G.: The Newer Knowledge of Nutrition , New York, Macmillan Company, 1939;,  chapter 11 .
Shohl, A. T.: Mineral Metabolism , New York, Reinhold Publishing Corporation, 1939;.  chapter 11 .
Underwood, E. J.:  The Significance of the "Trace Elements" in Nutrition , Nutrition Abstr. & Rev. 9:515-534 ( (Jan.) ) 1940;.
Godden. W.:  "Trace" Elements in Human and Animal Nutrition , J. Soc. Chem. Ind. 58:791-796 ( (Aug.) ) 1939;.
Baumann, E.:  Ueber das normale Vorkommen von Jod im Thierkörper , Ztschr. f. physiol. Chem. 21:319-330, 1895;-1896.
Harless, E.:  Ueber das blaue Blut einiger wirbellosen Thiere und dessen Kupfergehalt , Müller's Arch. Anat. Physiol. , 1847;, pp. 148-156.
Frédéricq, L.:  Sur l'hémocyanine, substance nouvelle du sang du poulpe , Comp. rend. Acad. d. sc. 87:996, 1878;.
Mendel, L. B., and Bradley, H. C.:  Experimental Studies on the Physiology of the Mollusks, Third Paper , Am. J. Physiol. 17:167-176, 1906;.
Henze, M.:  Untersuchungen über das Blut der Ascidien: I. Vanadiumverbindung der Blutkörperchen , Ztschr. f. physiol. Chem. 72:494-501, 1911;.
Griffiths, A. B.: Compt. rend. Acad. d. sc. 114:840, 1892;
von Oettingen: Physiol. Rev. 15:175-201 ( (April) ) 1935;.
Dutoit, P., and Zbinden, C.:  Analyse spectrographique des cendres de sang et d'organes , Compt. rend. Acad. d. sc. 188:1628-1629 ( (June) ) 1929;.
Sheldon, J. H., and Ramage, H.:  A Spectrographic Analysis of Human Tissues , Biochem. J. 25:1608-1627, 1931;.
Rusoff, L. L., and Gaddum, L. W.:  The Trace Element Content of the Newborn Rat (as Determined Spectrographically) , J. Nutrition 15:169-176 ( (Feb.) ) 1938;.
Wright, N. C., and Papish, J.:  The Inorganic Constituents of Milk , Science 69:78 ( (Jan. 18) ) 1929;.
Blumberg, H., and Rask, O. S.:  Spectrographic Analysis of Milk Ashes , J. Nutrition 6:285-288 ( (May) ) 1933;.
Drea, W. F.:  Spectrum Analysis of Milk Ashes , J. Nutrition 8:229-234 ( (Aug.) ) 1934;
 Spectrum Analysis for Trace Elements in the Ashes of Human, Goat and Cow Milk , DreaJ. Nutrition 16:325-331 ( (Oct.) ) 1938;.
Dingle, H., and Sheldon, J. H.:  A Spectrographic Examination of the Mineral Content of Human and Other Milk , Biochem. J. 32:1078-1086, 1938;.
Orent and McCollum.12 Kemmerer, Elvehjem and Hart.13
McCarrison, R.:  Effect of Manganese on Growth , Indian J. M. Res. 14:641-648 ( (Jan.) ) 1927;.
Levine, V. E., and Sohm, H. A.:  The Effect of Manganese on Growth , J. Biol. Chem. 59:xlviii, 1924;.
McHargue, J. S.:  Further Evidence That Small Quantities of Copper. Manganese and Zinc Are Factors in the Metabolism of Animals , Am. J. Physiol. 77:245-255 ( (July) ) 1926;.
Orent, E. R., and McCollum, E. V.:  Effects of Deprivation of Manganese in the Rat , J. Biol. Chem. 92:651-678 ( (Aug.) ) 1931;.
Kemmerer, A. R.; Elvehjem, C. A., and Hart, E. B.:  Studies on the Relation of Manganese to the Nutrition of the Mouse . J. Biol. Chem. 92:623-630 ( (Aug.) ) 1931;.
Daniels, Amy L., and Everson, Gladys, J.:  The Relation of Manganese to Congenital Debility , J. Nutrition 9:191-203 ( (Feb.) ) 1935;.
Shils, M. E., and McCollum, E. V., to be published.
Boyer, P. D.; Shaw, J. J., and Phillips, P. H.:  Studies on Manganese Deficiency in the Rat , J. Biol. Chem. 143:417-425 ( (April) ) 1942;.
Wilgus, H. S., Jr.; Norris, L. C., and Heuser, G. F.:  The Role of Manganese and Certain Other Trace Elements in the Prevention of Perosis , J. Nutrition 14:155-167 ( (Aug.) ) 1937;.
Gallup, W. D., and Norris, L. C.:  Essentialness of Manganese for Normal Development of Bone , Science 87:18-19 ( (Jan. 7) ) 1938;.
Caskey, C. D.; Gallup, W. D., and Norris, L. C.:  The Need for Manganese in the Bone Development of the Chick , J. Nutrition 17:407-417 ( (May) ) 1939;.
Wilgus, H. S., Jr., and Patton, A. R.:  Factors Affecting Manganese Utilization in the Chick , J. Nutrition 18:35-45 ( (July) ) 1939;.
Lyons, M., and Insko, W. M., Jr.:  Chondrodystrophy in the Chick Embryo Produced by a Mineral Deficiency in the Diet of the Hen , Poultry Sc. 16:365-366 ( (Sept.) ) 1937;.
Norris, L. C., and Caskey, C. D.:  A Chronic Congenital Ataxia and Osteodystrophy in Chicks Due to Manganese Deficiency , J. Nutrition 17:16-17, 1939;, Proc.
Caskey, C. D., and Norris, L. C.:  Micromelia in Adult Fowl Caused by Manganese Deficiency During Embryonic Development , Proc. Soc. Exper. Biol. & Med. 44:332-335 ( (June) ) 1940;.
Caskey, C. D., and Norris, L. C.:  Further Studies on the Role of Manganese in Poultry Nutrition , Poultry Sc. 17:433, 1938;, Proc.
Barnes, L. L.; Sperling, G., and Maynard, L. A.:  Bone Development in the Albino Rat on a Low Manganese Diet , Proc. Soc. Exper. Biol. & Med. 46:562-565 ( (April) ) 1941;.
Miller, R. C.; Keith, T. B.; McCarty, M. A., and Thorp, W. T. S.:  Manganese as a Possible Factor Influencing the Occurrence of Lameness in Pigs , Proc. Soc. Exper. Biol. & Med. 45:50-51 ( (Oct.) ) 1940;.
Lyons, M.; Insko, W. M., Jr., and Martin, J. H.:  The Effect of Intraperitoneal Injections of Manganese, Zinc, Aluminum and Iron Salts on the Occurrence of Slipped Tendon in Chicks , Poultry Sc. 17:12-16 ( (Jan.) ) 1938;
 The Effect of Manganese, Zinc, Aluminum and Iron Salts on the Incidence of Perosis in Chicks , LyonsPoultry Sc. 17:264-269 ( (July) ) 1938;.
Jukes, T. H.:  Effect of Choline and Other Supplements on Perosis , J. Nutrition 20:445-458 ( (Nov.) ) 1940;.
Jukes, T. H., and Bird, F. H.:  Prevention of Perosis by Biotin , Proc. Soc. Exper. Biol. & Med. 49:231-232 ( (Feb.) ) 1942;.
Combs, G. F.; Norris, L. C., and Heuser, G. F.:  The Interrelationship of Manganese, Phosphatase, and Vitamin D in Bone Development , J. Nutrition 23:131-140 ( (Feb.) ) 1942;.
Ghormley, R. K., and Fairchild, R. D.:  The Diagnosis and Treatment of Slipped Epiphyses , J. A. M. A. 114:229-235 ( (Jan. 20) ) 1940;.
Perla and Sandberg.28 Sandberg, Perla and Holly.29
Perla, D., and Sandberg, M.:  Metabolic Interdependence of Vitamin B1 and Manganese: Reciprocal Neutralization of Their Toxic Effects , Proc. Soc. Exper. Biol. & Med. 41:522-527 ( (June) ) 1939;.
Sandberg, M.; Perla, D., and Holly, O. M.:  Interdependence of Vitamin B1 and Manganese; Manganese, Copper and Iron Metabolism in B1 Deficient Rats , Proc. Soc. Exper. Biol. & Med. 42:368-371 ( (Nov.) ) 1939;.
Collison, R. C.: Minor Elements and Crop Fertilization, New York (Geneva) Agr. Expt. Sta. Circ. 168, 1937, pp. 1-13.
Steinberg, R. A.:  Growth of Fungi in Synthetic Nutrient Solutions , Botan. Rev. 5:327-350 ( (June) ) 1939;.
Woolley, D. W.:  Manganese and the Growth of Lactic Acid Bacteria , J. Biol. Chem. 140:311-312 ( (July) ) 1941;.
Everson, Gladys J., and Daniels, Amy L.:  A Study of Manganese Retentions in Children , J. Nutrition 8:497-502 ( (Nov.) ) 1934;.
Macy, Icie G.: Nutrition and Chemical Growth in Childhood , Springfield, Ill., Charles C. Thomas, 1942;, vol 1,  Evaluation, chapter 3 .
Kehoe, R. A.; Cholak, J., and Story, R. V.:  Manganese, Lead, Tin, Aluminum, Copper and Silver in Normal Biological Material , J. Nutrition 20:85-98 ( (July) ) 1940;.
Remington, R. E., and Shiver, H. E.:  Iron, Copper and Manganese Content of Some Common Vegetables , J. A. Off. Agr. Chem. 13:129-132, 1930;.
Hodges, Mildred A., and Peterson. W. H.:  Manganese, Copper and Iron Content of Serving Portions of Common Foods , J. Am. Dietet. A. 7:6-16 ( (June) ) 1931;.
Lindow, C. W., and Peterson, W. H.:  The Manganese Content of Plant and Animal Materials , J. Biol. Chem. 75:169-175 ( (Oct.) ) 1927;.
Peterson. W. H., and Skinner, J. T.:  Distribution of Manganese in Foods , J. Nutrition 4:419-426 ( (Sept.) ) 1931;.
Kehoe, R. A.; Cholak, J., and Story, R. V.:  Spectrochemical Study of the Normal Ranges of Concentration of Certain Trace Metals in Biological Materials , J. Nutrition 19:579-592 ( (June) ) 1940;.
Ramage, H.; Sheldon, J. H., and Sheldon, W.:  A Spectrographic Investigation of the Metallic Content of the Liver in Childhood , Proc. Roy. Soc. 113:308-327 ( (Aug.) ) 1933;.
Gruzewska, Z. (Mme.), and Roussel, G.:  Le manganèse dans le foie foetal au cours de son développement , Bull. Soc. chim. biol. 21:730-736 ( (May) ) 1939;.
Skinner, J. T.; Peterson, W. H., and Steenbock, Harry:  The Manganese Metabolism of the Rat , J. Biol. Chem. 90:65-80 ( (Jan.) ) 1931;.
Greenberg, D. M., and Campbell, W. W.:  Studies in Mineral Metabolism with the Aid of Induced Radioactive Isotopes: IV. Manganese , Proc. Nat. Acad. Sc. 26:448-452 ( (July) ) 1940;.
Hart, E. B.; Steenbock, Harry; Waddell, J., and Elvehjem, C. A.:  Iron in Nutrition: Copper as a Supplement to Iron for Hemoglobin Building in the Rat , J. Biol. Chem. 77:797-812 ( (May) ) 1928;.
Titus, R. W.; Cave, H. W., and Hughes, J. S.:  Manganese-Copper-Iron Complex as a Factor in Hemoglobin Building , J. Biol. Chem. 80:565-570 ( (Dec.) ) 1928;.
Myers, V. C., and Beard, H. H.:  The Influence of Inorganic Elements on Blood Regeneration in Nutritional Anemia , J. A. M. A. 93:1210-1212 ( (Oct. 19) ) 1929;.
Elvehjem, C. A.:  Biological Significance of Copper and Its Relatiton to Iron Metabolism , Physiol. Rev. 15:471-507 ( (July) ) 1935;.
von Oettingen, W. F.:  Manganese: Its Distribution, Pharmacology and Health Hazards , Physiol. Rev. 15:175-201 ( (April) ) 1935;.
Bertrand, G.:  Sur l'intervention du manganèse dans les oxydations provoqués par la laccase , Compt. rend. Acad. d. sc. 124:1032-1035, 1897;.
Keilin, D., and Mann, T.:  Laccase, a Blue Copper-Protein Oxidase from the Latex of Rhus Succedanea , Nature 143:23 ( (Jan. 7) ) 1939;.
Wiese, A. C.; Johnson, B. C.; Elvehjem, C. A.; Hart, E. B., and Halpin, J. G.:  A Study of Blood and Bone Phosphatase in Chick Ferosis , J. Biol. Chem. 127:411-420 ( (Feb.) ) 1939;.
Wiese, A. C.; Benham, G. H.; Elvehjem, C. A., and Hart, E. B.:  Further Bone Phosphatase Studies in Chick Perosis , Poultry Sc. 20:255-258 ( (May) ) 1941;.
Bamann, E., and Heumüller, E.:  Ueber die Aktivierung von Phosphatasen durch verschiedene Metall-Ionen , Naturwissensch. 28:535 ( (Aug. 16) ) 1940;.
Massart, L., and Dufait, R.:  Fluoridhemmung und Metallaktivierung der Hefephosphatase , Naturwissensch. 27:806-807 ( (Dec. 1) ) 1939;.
Cloetens, R.:  Aktivierung und Hemmung der alkalischen Phosphatasen , Naturwissensch. 27:806 ( (Dec. 1) ) 1939;.
Krebs, H. A., and Henseleit, K.:  Untersuchungen über die Harnstoffbildung im Tierkörper , Ztschr. f. physiol. Chem. 210:33-66, 1932;.
Edlbacher, S., and Pinösch, H.:  Ueber die Natur der Arginase , Ztschr. f. physiol. Chem. 250:241-248, 1937;.
Richards, Marianna M., and Hellerman, L.:  Purified Liver Arginase; Reversible Inactivation and Reactivation , J. Biol. Chem. 134:237-252 ( (June) ) 1940;.
Shils and McCollum.15 Boyer, Shaw and Phillips.15a
Cori, G. T.; Colowick, S. P., and Cori, C. F.:  The Enzymatic Conversion of Glucose-1-phosphoric Ester to 6-ester in Tissue Extracts , J. Biol. Chem. 124:543-555 ( (July) ) 1938;.
Berger, J., and Johnson, M. J.:  Metal Activation of Peptidases , J. Biol. Chem. 130:641-654 ( (Oct.) ) 1939;.
Smith, E. L., and Bergmann, M.:  The Activation of Intestinal Peptidases by Manganese , J. Biol. Chem. 138:789-790 ( (April) ) 1941;.
Massart, L., and Dufait, R.:  Activations et inhibitions de la cholinesterase , Enzymologia 6:282-286, 1939;.
Nachmansohn, D.:  Action of Ions on Choline Esterase , Nature 145:513-514 ( (March 30) ) 1940;.
Ohlmeyer, P., and Ochoa, S.:  Ueber die Rolle des Mangans für die Phosphat übertragende Funktion der Cozymase , Naturwissensch. 25:253 ( (April 16) ) 1937;.
Adler, E.; von Euler, H.; Günther, G., and Plass, M.:  Isocitric Dehydrogenase and Glutamic Acid Synthesis in Animal Tissues , Biochem. J. 33:1028-1045, 1939;.
Green, D. E.; Herbert, D., and Subrahmanyan, V.:  Carboxylase , J. Biol. Chem. 138:327-339 ( (March) ) 1941;
Green, D. E.; Westerfeld, W. W.; Vennesland, B., and Knox, W. E.:  Pyruvic and Ketoglutaric Carboxylases of Animal Tissues , J. Biol. Chem. 140:683-684 ( (Aug.) ) 1941;.
Engelhardt, W. A., and Liubimowa, M. N.:  Myosine and Adenosinetriphosphatase , Nature 144:668-669 ( (Oct. 14) ) 1939;.
Bailey, K.:  Myosin and Adenosinetriphosphatase , Biochem. J. 36:121-139 ( (Feb.) ) 1942;.
Rudra, M. N.:  Role of Manganese in the Biological Synthesis of Ascorbic Acid , Nature 144:868 ( (Nov. 18) ) 1939;.
Orent and McCollum.12 Kemmerer, Elvehjem and Hart.13 Daniels and Everson.14 Shils and McCollum.15 Boyer, Shaw and Phillips.15a
Footnote deleted on proof.
Ahmad, B., and McCollum, E. V.:  The Cobalt Content of Some Food Materials from Different Parts of the United States , Am. J. Hyg. 29:24-26 ( (Jan.) ) 1939;.
Copp, D. H., and Greenberg, D. M.:  Studies in Mineral Metabolism with the Aid of Artificial Radioactive Isotopes: VI. Cobalt , Proc. Nat. Acad. Sc. 27:153-157 ( (March) ) 1941;.
Kent, N. L., and McCance, R.:  The Absorption and Excretion of "Minor" Elements by Man: 2. Cobalt, Nickel, Tin and Manganese , Biochem. J. 35:877-883 ( (Sept.) ) 1941;.
Bertrand, G.:  The Importance of Minute Chemical Constituents of Biological Products: Nickel, Cobalt and Insulin , Science 64:629-630 ( (Dec. 26) ) 1926;.
Blatherwick, N. R., and Sahyun, M.:  The Effect of Cobalt on Insulin Hypoglycemia in Rabbits , Am. J. Physiol. 81:560-562 ( (Aug.) ) 1927;.
Magenta, M. A.:  Action des sels de nickel et de cobalt sur l'hypoglycémie insulinique , Compt. rend. Soc. de biol. 98:169-170 ( (Jan. 20) ) 1928;.
Scott, D. A., and Fisher, A. M.:  The Effect of Zinc Salts on the Action of Insulin , J. Pharmacol. & Exper. Therap. 55:206-221 ( (Oct.) ) 1935;.
Waltner. Klara, and Waltner, K.:  Kobalt und Blut , Klin. Wchnschr. 8:313 ( (Feb. 12) ) 1929;.
Stare, F. J., and Elvehjem, C. A.:  Cobalt in Animal Nutrition , J. Biol. Chem. 99:473-483 ( (Jan.) ) 1933;.
Orten, J. M.; Underhill, F. A.; Mugrage, E. R., and Lewis, R. C.:  Polycythemia in the Rat on a Milk-Iron-Copper Diet Supplemented by Cobalt , J. Biol. Chem. 96:11-16 ( (April) ) 1932;.
Mascherpa, P.:  Le pouvoir hématopoietique du cobalt , Arch. ital. de Biol. 82:112-120, 1930;.
Kleinberg, W.; Gordon, A. S., and Charipper, H. A.:  Effect of Cobalt on Erythropoiesis in Anemic Rabbits , Proc. Soc. Exper. Biol. & Med. 42:119-120 ( (Oct.) ) 1939;.
Orten, J. M.:  On the Mechanism of the Hematopoietic Action of Cobalt , Am. J. Physiol. 114:414-422 ( (Jan.) ) 1936;.
Davis, J. E.:  The Effect of Ascorbic Acid Administration on Experimental Polycythemias: The Mechanism of Cobalt Polycythemia , Am. J. Physiol. 129:140-145 ( (April) ) 1940;.
Orten, J. M.; Underhill, F. M.; Mugrage, E. R., and Lewis, R. C.:  The Effect of Manganese on Cobalt Polycythemia , J. Biol. Chem. 99:465-468 ( (Jan.) ) 1933;.
Barron, A. G., and Barron, E. S. G.:  Mechanism of Cobalt Polycythemia: Effect of Ascorbic Acid , Proc. Soc. Exper. Biol. & Med. 35:407-409 ( (Dec.) ) 1936;.
Davis, J. E.:  Depression of Experimental Polycythemia by Choline Hydrochloride or Liver Administration , Am. J. Physiol. 127:322-327 ( (Sept.) ) 1939;
 The Depression of Experimental Polycythemias by Various Substances in Dogs, Rabbits and Man , J. Pharmacol. & Exper. Therap. 73:162-169 ( (Oct.) ) 1941;.
Anderson, H. D.; Underwood, E. J., and Elvehjem, C. A.:  Factors Affecting the Maintenance of Cobalt Polycythemia in the Rat , Am. J. Physiol. 130:373-378 ( (Aug.) ) 1940;.
Griffith, W. H.; Pavcek, P. L., and Mulford, D. J.:  The Relation of the Sulfur Amino Acids to the Toxicity of Cobalt and Nickel in the Rat , J. Nutrition 23:603-612 ( (June) ) 1942;.
Frost, D. V.; Spitzer, E. H.; Elvehjem, C. A., and Hart, E. B.:  Some Effects of Cobalt and Liver Substance on Blood Building in Dogs , Am. J. Physiol. 134:746-754 ( (Nov.) ) 1941;.
Filmer, J. F., and Underwood, E. J.:  Enzootic Marasmus: Further Data Concerning the Potency of Cobalt as a Curative and Prophylactic Agent , Australian Vet. J. 13:57-64, 1937;.
Schultze, M. O.:  The Relation of Copper to Cytochrome Oxidase and Hematopoietic Activity of the Bone Marrow of Rats , J. Biol. Chem. 138:219-224 ( (March) ) 1941;.
Underwood, E. J.:  The Significance of the "Trace Elements" in Nutrition , Nutrition Abstr. & Rev. 9:515-534 ( (Jan.) ) 1940;.
Underwood, E. J.:  Enzootic Marasmus Iron Content of Liver, Kidney and Spleen , Australian Vet. J. 10:87-92, 1934;.
Filmer, J. F., and Underwood, E. J.:  Enzootic Marasmus: Treatment with Limonite Fractions , Australian Vet. J. 10:83-87, 1934;.
Marston, H. R.:  Problems Associated with "Coast Disease" in South Australia , Comm. Austral. J. Counc. Sc. Ind. Res. 8:111-116 ( (May) ) 1935;.
Lines, E. W.:  The Effect of the Ingestion of Minute Quantities of Cobalt by Sheep Affected with "Coast Disease": A Preliminary Note , Comm. Austral. J. Counc. Sc. Ind. Res. 8:117 ( (May) ) 1935;.
Underwood, E. J., and Filmer, J. F.:  The Determination of the Biologically Potent Element Cobalt in Limonite , Australian Vet. J. 11:84-92, 1935;.
Askew, H. O., and Dixon, J. K.:  The Importance of Cobalt in the Treatment of Certain Stock Ailments in the South Island, New Zealand , New Zealand J. Sc. Technol. 18:73-84 ( (July) ) 1936;.
Neal, W. M., and Ahmann, C. F.:  The Essentiality of Cobalt in Bovine Nutrition , J. Dairy Sc. 20:741-753, 1937;.
Ann. Repts. Dept. Agr. Kenya 1936, 1937
Corner, H. H., and Smith, A. M.:  The Influence of Cobalt on Pine Disease in Sheep , Biochem. J. 32:1800-1805 ( (Oct.) ) 1938;.
Bowstead, J. E., and Sackville, J. P.:  Studies with a Deficient Ration for Sheep: 2. Effects of Cobalt Supplement , Canad. J. Res. D. 17:15, 1939;
Nutrition Abstr. & Rev. 9:241, 1939;.
Balzer, A. C.; Killham, B. J.; Duncan, C. W., and Huffman, C. F.:  Cobalt Deficiency Disease Observed in Some Michigan Dairy Cattle , Michigan Agri. Exper. Sta. Quart. Bull. 24:68-70 ( (Aug.) ) 1941;.
Marston, H. R.; Lines, E. W.; Thomas, R. G., and McDonald, I. W.:  Cobalt and Copper in Ruminant Nutrition , Nature 141:398-400 ( (March 5) ) 1938;.
Underwood, E. J., and Elvehjem, C. A.:  Is Cobalt of Any Significance in the Treatment of Milk Anemia with Iron and Copper? J. Biol. Chem. 124:419-424 ( (July) ) 1938;.
Frost, D. V.; Elvehjem, C. A., and Hart, E. B.:  A Study of the Need for Cobalt in Dogs on Milk Diets , J. Nutrition 21:93-100 ( (Jan.) ) 1941;.
Kato, K.:  Iron-Cobalt Treatment of Physiologic and Nutritional Anemia in Infants , J. Pediat. 11:385-396 ( (Sept.) ) 1937;.
Baxter, C. R.:  Copper and Cobalt in Anemia , Brit. M. J. 1:534-535 ( (March 11) ) 1939;.
Cronin, E.:  Copper and Cobalt in Anemia , Brit. M. J. 1:643 ( (March 25) ) 1939;.
Waltner, K.:  Therapeutische Versuche mit Kobalt , Acta pediat. 11:438-440 ( (Aug.) ) 1930;.
See section on manganese.
Bertrand, G., and Benzon, B.:  Sur l'importance du zinc dans l'alimentation des animaux: Expériences sur la souris , Comp. rend. Acad. d. sc. 175:289-292, 1922;.
McHargue, J. S.:  Further Evidence That Small Quantities of Copper, Manganese and Zinc Are Factors in the Metabolism of Animals , Am. J. Physiol. 77:245-255 ( (July) ) 1926;.
Hubbell, Rebecca B., and Mendel, L. B.:  Zinc and Normal Nutrition. J. Biol. Chem. 75:567-586, 1927;.
Bertrand, G., and Bhattacherjee, R. C.:  L'action combinée du zinc et des vitamines dans l'alimentation des animaux , Comp. rend. Acad. d. sc. 198:1823-1827 ( (May 23) ) 1934;.
Todd, W. R.; Elvehjem, C. A., and Hart, E. B.:  Zinc in the Nutrition of the Rat , Am. J. Physiol. 107:146-156 ( (Jan.) ) 1934;.
Stirn, F. E.; Elvehjem, C. A., and Hart, E. B.:  The Indispensability of Zinc in Nutrition of the Rat , J. Biol. Chem. 109:347-359 ( (April) ) 1935;.
Hove, E.; Elvehjem, C. A., and Hart, E. B.:  The Physiology of Zinc in the Nutrition of the Rat; 122 Further Studies on Zinc Deficiency in Rats , Am. J. Physiol. 124:750-758 ( (Dec.) ) 1938;.
Day, H. G., and McCollum, E. V.:  Effects of Acute Dietary Zinc Deficiency in the Rat , Proc. Soc. Exper. Biol. & Med. 45:282-284, 1940;.
Day, H. G.:  The Effects of Zinc Deficiency in the Mouse , Federation Proc. 1:188-189 ( (March) ) 1942;.
Follis, R. H., Jr., and Day, H. G.:  Histological Studies of the Tissues of Rats Fed a Diet Extremely Low in Zinc , J. Nutrition 22:223-237 ( (Sept.) ) 1941;.
Bessey, O. A., and Wolbach, S. B.:  Vascularization of the Cornea of the Rat in Riboflavin Deficiency with a Note on Corneal Vascularization in Vitamin A deficiency , J. Exper. Med. 69:1-12 ( (Jan.) ) 1939;.
Scott, D. A.:  Crystalline Insulin , Biochem. J. 28:1592-1602, 1934;.
Scott, D. A., and Fisher, A. M.:  Crystalline Insulin , Biochem. J. 29:1048-1054, 1935;.
Cohn, E. J.; Ferry, J. D.; Livingood, J. J., and Blanchard, M. H.:  The Solubility and Dielectric Properties of Insulin and Its Crystallization with Radioactive Zinc , Science 90:183-185 ( (Aug. 25) ) 1939;.
Bischoff, F., and Jemtegaard, L. M.:  Divided Dosage of Insulin , Am. J. Physiol. 119:149-152 ( (May) ) 1937;.
Blatherwick, N. R.; Ewing, Mary E., and Bradshaw, Phoebe J.:  Some Effects of Zinc and Iron Salts on the Hypoglycemic Action of Insulin in Rats , Am. J. Physiol. 121:44-48 ( (Jan.) ) 1938;.
Scott, D. A., and Fisher, A. M.:  The Insulin and the Zinc Content of Normal and Diabetic Pancreas , J. Clin. Investigation 17:725-728 ( (Nov.) ) 1938;.
Eisenbrand, J., and Sienz, M.:  Ueber den Zinkgehalt von menschlichen Pankreasdrüsen , Ztschr. f. physiol. Chem. 268:1-35 ( (March) ) 1941;.
Roughton, F. J. W.:  Recent Work on the Carbon Dioxide Transport by the Blood , Physiol. Rev. 15:241-296 ( (April) ) 1935;.
Keilin, D., and Mann, T.:  Carbonic Anhydrase , Nature 144:442-443 ( (Sept. 2) ) 1939;.
Hove, E.; Elvehjem, C. A., and Hart, E. B.:  The Relation of Zinc to Carbonic Anhydrase , J. Biol. Chem. 136:425-434 ( (Nov.) ) 1940;.
Scott, D. A., and Mendive, J. R.:  Chemical Observations on Carbonic Anhydrase , J. Biol. Chem. 140:445-451 ( (Aug.) ) 1941;.
Davenport, H. W.:  Gastric Carbonic Anhydrase , J. Physiol. 97:32-43 ( (Nov.) ) 1939;.
van Goor, H.:  La répartition de l'anhydrase carbonique dans l'organisme des animaux , Arch. internat. physiol. 45:491-509 ( (Dec.) ) 1937;.
Tucker, Helen F., and Ball, E. G.:  The Activity of Carbonic Anhydrase in Relation to the Secretion and Composition of Pancreatic Juice , J. Biol. Chem. 139:71-80 ( (May) ) 1941;.
Davenport, H. W., and Wilhelmi, A. E.:  Renal Carbonic Anhydrase , Proc. Soc. Exper. Biol. & Med. 48:53-56 ( (Oct.) ) 1941;.
Keilin and Mann.114 Hove, Elvehjem and Hart.115
Mann, T., and Keilin, D.:  Sulfanilamide as a Specific Inhibitor of Carbonic Anhydrase , Nature 146:164-165 ( (Aug. 3) ) 1940;.
Holmberg, C. G.:  Uricase Purification and Properties , Biochem. J. 33:1901-1906, 1939;.
Davidson, J. N.:  The Purification of Uricase. 2. Some Properties of Purified Uricase , Biochem. J. 36:252-258 ( (Feb.) ) 1942;.
Hove, E.; Elvehjem, C. A., and Hart, E. B.:  The Physiology of Zinc in the Nutrition of the Rat , Am. J. Physiol. 119:768-775 ( (Aug.) ) 1937;.
Hove, Elvehjem and Hart.115 Day and McCollum.104
Wachtel, L. W.; Hove, E.; Elvehjem, C. A., and Hart, E. B.:  Blood Uric Acid and Liver Uricase of Zinc Deficient Rats on Various Diets , J. Biol. Chem. 138:361-368 ( (March) ) 1941;.
Hove, Elias; Elvehjem, C. A., and Hart, E. B.  The Effect of Zinc on Alkaline Phosphatases , J. Biol. Chem. 134:425-442 ( (June) ) 1940;.
Lutz, R. E.:  The Normal Occurrence of Zinc in Biological Materials: A Review of the Literature and a Study of the Normal Distribution of Zinc in the Rat, Cat and Man , J. Indust. Hyg. 8:177-207, 1926;.
Eggleton, W. G. E.:  The Zinc Content of Epidermal Structures in Beriberi , Biochem. J. 33:403-406 ( (April) ) 1939;.
Scoular, Florence I.:  A Quantitative Study, by Means of Spectrographic Analysis, of Zinc in Nutrition , J. Nutrition 17:103-113 ( (Feb.) ) 1939;.
Stern, A.; Naldar, Margaret, and Macy, Icie G.:  Zinc Retention in Childhood , J. Nutrition 21:8, 1941;, Proc.
Macy, Icie G.: Nutrition and Chemical Growth in Childhood , vol. 1, Evaluation, Springfield, Ill., Charles C. Thomas, 1942;.
McClure, F. J.: Fluorides in Food and Drinking Water , Bulletin 172, Nat. Inst. Health, 1939;.
McKay, F. S., in collaboration with Black, G. V.:  An Investigation of Mottled Teeth , Dent. Cosmos 58:477-484 ( (May) ), 627-644 (June) 1916;.
Churchill, H. V.:  Occurrence of Fluorides in Some Waters of the United States , Indust. & Engin. Chem. 23:996-998 ( (Sept.) ) 1931;.
Smith, Margaret C.; Lantz, E. M., and Smith, H. V.: The Cause of Mottled Enamel, a Defect of Human Teeth , Tech. Bull. 32, Univ. Arizona Agr. Exper. Stat., (June) 1931;, pp. 253-282.
Velu, H.:  Dystrophie dentaire des mammifères des zones phosphatées (darmous) et fluorose chronique , Comp. rend. Soc. de biol. 108:750-752 ( (Nov. 21) ) 1931;.
Dean, H. T., and Elvove, E.:  Further Studies on the Minimal Threshold of Chronic Endemic Fluorosis , Pub. Health Rep. 52:1249-1264 ( (Sept. 10) ) 1937;.
Black, G. V., in collaboration with McKay, F. S.:  Mottled Teeth: An Endemic Developmental Imperfection of the Teeth, Heretofore Unknown in the Literature of Dentistry , Dent. Cosmos 58:129-156 ( (Feb.) ) 1916;.
Williams, J. L.:  Mottled Enamel and Other Studies of Normal and Pathological Conditions of This Tissue , J. Dent. Res. 5:117-195, ( (Sept.) ) 1923;.
Beust, T. B.:  A Contribution to the Etiology of Mottled Enamel. J. Am. Dent. A. 12:1059-1066 ( (Sept.) ) 1925;.
Ainsworth, N. J.:  Mottled Teeth , Brit. Dent. J. 55:233-250, 274-276 ( (Sept.) ) 1933;.
Dean, H. T.:  Chronic Endemic Dental Fluorosis (Mottled Enamel) , J. A. M. A. 107:1269-1272 ( (Oct. 17) ) 1936;.
Dean, H. T., and McKay, F. S.:  Production of Mottled Enamel Halted by Change in the Common Water Supply , Am. J. Pub. Health 29:590-596 ( (June) ) 1939;.
Nichols, M. S.:  Occurrence, Pathological Aspects and Treatment of Fluoride Waters , Am. J. Pub. Health 29:991-998 ( (Sept.) ) 1939;.
Dean, H. T.:  Fluorine, Mottled Enamel and Dental Caries , J. Pediat. 16:782-794 ( (June) ) 1940;
Hawkins, J. W., and Gordon, J. E.:  Epidemiological Aspects of Mottled Enamel , Am. J. M. Sc. 199:431-446 ( (March) ) 1940;.
Roholm, K.: Fluorine Intoxication , London, H. K. Lewis Ltd., 1937;.
Greenwood, D. A.:  Fluoride Intoxication , Physiol. Rev. 20:582-616 ( (Oct.) ) 1940;.
McCollum, E. V.; Simmonds, Nina; Becker, J. Ernestine, and Bunting, R. W.:  The Effect of Additions of Fluorine to the Diet of the Rat on the Quality of the Teeth , J. Biol. Chem. 63:553-562 ( (April) ) 1925;.
Schulz, J. A., and Lamb, A. R.:  The Effect of Fluorine as Sodium Fluoride on the Growth and Reproduction of Albino Rats , Science 61:93-94 ( (Jan. 23) ) 1925;.
McCollum, Simmonds, Becker and Bunting.141 Schulz and Lamb.142
Peirce, A. W.:  Chronic Fluorine Intoxication in Domestic Animals , Nutrition Abstr. & Rev. 9:253-261 ( (Oct.) ) 1939;.
Bosworth, T. J.; Green, H. H., and Murray, M. M.:  Discussion on Fluorosis in Man and Animals , Proc. Roy. Soc. Med. 34:391-396 ( (May) ) 1941;.
Morgareidge, K., and Finn, S. B.:  Effect of Fluorine on the Activity of Vitamin D in Rachitic Rats , J. Nutrition 20:75-84 ( (July) ) 1940;.
Finn, B. B., and Kramer, M.:  Effect of Fluorine on Life Span of Rachitic Rats , Proc. Soc. Exper. Biol. & Med. 45:843-845 ( (Dec.) ) 1940;.
Glock, G. E.:  Glycogen and Calcification , J. Physiol. 98:1-11 ( (March) ) 1940;.
Hodges, P. C.; Fareed, O. J.; Ruggy, George, and Chudnof, J. S.:  Skeletal Sclerosis in Chronic Sodium Fluoride Poisoning , J. A. M. A. 117:1938 ( (Dec. 6) ) 1941;.
Smith, Margaret C.:  Fluorine Toxicosis: A Public Health Problem , Am. J. Pub. Health 25:696-702 ( (June) ) 1935;.
Shortt, H. E.; McRobert, G. R.; Barnard, T. W., and Nayar, A. S. M.:  Endemic Fluorosis in the Madras Presidency , Indian J. M. Res. 25:553-568 ( (Oct.) ) 1937;.
DeEds, Floyd:  Factors in the Etiology of Mottled Enamel , J. Am. Dent. A. 28:1804-1814 ( (Nov.) ) 1941;.
Smith, Margaret C., and Lantz, Edith M.:  The Effect of Fluorine on the Phosphatase Content of Plasma, Bones and Teeth of Albino Rats , J. Biol. Chem. 112:303-311 ( (Dec.) ) 1935;.
Ochoa, S.:  "Coupling" of Phosphorylation with Oxidation of Pyruvic Acid in Brain , J. Biol. Chem. 138:751-773 ( (April) ) 1941;.
Massart, L., and Dufait, R.:  Fluoridhemmung und Metallaktivierung der Hefephosphatase , Naturwissensch. 27:806-807 ( (Dec. 1) ) 1939;.
Loevenhart, A. S., and Peirce, G.:  The Inhibiting Effect of Sodium Fluoride on the Action of Lipase , J. Biol. Chem. 2:397-413, 1908;.
Phillips, P. H.; English, H. E., and Hart, E. B.:  The Influence of Sodium Fluoride on the Basal Metabolism of the Rat Under Several Experimental Conditions , Am. J. Physiol. 113:441-449 ( (Oct.) ) 1935;.
Phillips, P. H.; English, H. E., and Hart, E. B.:  The Augmentation of the Toxicity of Fluorosis in the Chick by Feeding Desiccated Thyroid , J. Nutrition 10:399-407 ( (Oct.) ) 1935;.
Wilson, R. H., and DeEds, Floyd:  Synergistic Action of Thyroid on Fluorine Toxicity , Endocrinology 26:851-856 ( (May) ) 1940;.
DeEds, Floyd; Wilson, R. H., and Cutting, W. C.:  Thyrotropic Hormone and Fluorine Activity , Endocrinology 26:1053-1056 ( (June) ) 1940;.
Phillips, P. H.; Hart, E. B., and Bohstedt, G.:  The Influence of Fluorine Ingestion on the Nutritional Qualities of Milk , J. Biol. Chem. 105:123-134 ( (April) ) 1934;.
Smith, Margaret C.; Vavich, M., and Smith, H. V.:  Fluorine Content of Milk as Affected by the Amount of Fluorine in the Drinking Water of the Cow , J. Dent. Res. 20:286-287 ( (June) ) 1941;, Proc.
Brinch, O., and Roholm, K.: Paradentium 6:147, 1934;
Hart, E. B.; Phillips, P. H., and Bohstedt, G.:  Relation of Soil Fertilization with Superphosphate and Rock Phosphate to Fluorine of Plants and Drainage Waters , Am. J. Pub. Health 24:936-940 ( (Sept.) ) 1934;.
Mackle, W.; Scott, E. W., and Treon, J.:  Normal Urinary Fluoride Excretion and the Fluorine Content of Food and Water , Am. J. Hyg. 29:139-145 (sec. A., (May) ) 1939;.
DeEds, F.:  The Toxicity of Fluorine in Dicalcium Phosphate , Am. J. M. Sc. 203:687-692 ( (May) ) 1942;.
Armstrong, W. D.:  Fluorine Content of Enamel and Dentin of Sound and Carious Teeth , Proc. Am. Soc. Biol. Chem., J. Biol. Chem. 119:v, 1937;.
Armstrong, W. D., and Brekhus, P. J.:  Possible Relationship Between the Fluorine Content of Enamel and Resistance to Dental Caries , J. Dent. Res. 17:393-399 ( (Oct.) ) 1938;.
Bunting, R. W.; Crowley, M.; Hard, D. H., and Keller, M.:  Further Studies on Relation of B. Acidophilus to Dental Caries , Dent. Cosmos 70:1002-1009 ( (Oct.) ) 1928;.
McKay, F. S.:  Establishment of Definite Relation Between Enamel That Is Defective in Structure, as Mottled Enamel, and Its Liability to Decay , Dent. Cosmos 71:747-755 ( (Aug.) ) 1929;.
Arnim, S. S.; Aberle, S. D., and Pitney, E. H.:  A Study of Dental Changes in a Group of Pueblo Indian Children , J. Am. Dent. A. 24:478-480 ( (March) ) 1937;.
Masaki, T.; Gakuho Shikwa 26:17, 1931;
Dean, H. T.:  Endemic Fluorosis and Its Relation to Dental Caries , Pub. Health Rep. 53:1443-1452 ( (Aug. 19) ) 1938;.
Dean, H. T.; Jay, P.; Arnold, F. A., Jr.; McClure, F., and Elvove, E.:  Domestic Water and Dental Caries, Including Certain Epidemiological Aspects of Oral L. Acidophilus , Pub. Health Rep. 54:862-888 ( (May 26) ) 1939;.
Dean, H. T.; Jay, P.; Arnold, F. A., Jr., and Elvove, E.:  Domestic Water and Dental Caries: II. A Study of 2,832 White Children, Aged 12 to 14 Years, of Eight Suburban Chicago Communities, Including Lactobacillius Acidophilus Studies of 1,761 Children , Pub. Health Rep. 56:761-792 ( (April 11) ) 1941;.
Dean, H. T.; Jay, P.; Arnold, F. A., Jr., and Elvove, E.:  A Dental Caries Study, Including L. Acidophilus Estimations of a Population Severely Affected by Mottled Enamel and Which for the Past Twelve Years Has Used a Fluoride Free Water , Pub. Health Rep. 56:365-381 ( (Feb. 28) ) 1941;.
Arnold, F. A.; Dean, H. T., and Elvove, E.:  Domestic Water and Dental Caries, IV. Effect of Increasing the Fluoride Content of a Common Water Supply on the Lactobacillus Acidophilus Counts of the Saliva , Pub. Health Rep. 57:773-780 ( (May 22) ) 1942;.
Cox, G. J.: Matuschak, Margaret C.; Dixon, Sara F.; Dodds, Mary L., and Walker, W. E.:  Fluorine and Its Relation to Dental Caries , J. Dent. Res. 18:481-490 ( (Dec.) ) 1939;.
Miller, B. F.:  Inhibition of Experimental Dental Caries in the Rat by Fluoride and Iodoacetic Acid , Proc. Soc. Exper. Biol. & Med. 39:389-393 ( (Nov.) ) 1938;.
Hodge, H. C., and Finn. S. B.:  Reduction in Experimental Rat Caries by Fluorine , Proc. Soc. Exper. Biol. & Med. 42:318-320 ( (Oct.) ) 1939;.
Sognnaes. R. F.:  Effect of Local and Systemic Fluorine Administration on Experimental Rat Caries , J. Dent. Res. 19:287 ( (June) ) 1940;, Proc.
Cheyne, V. D.:  Inhibition of Experimental Dental Caries by Fluorine in the Absence of Saliva , Proc. Soc. Exper. Biol. & Med. 43:58-61 ( (Jan.) ) 1940;
 Study of the Mechanism of Inhibition of Dental Caries by Fluorine , J. Dent. Res. 19:280-281 ( (June) ) 1940;
McClure, F. J., and Arnold, F. A.. Jr.:  Observations on Induced Dental Caries in Rats: Reduction by Fluorides and Iodoacetic Acid . J. Dent. Res. 20:97-105 ( (April) ) 1941;.
Finn, S. B., and Hodge, H. C.:  Reduction in Experimental Caries by Fluorine . J. Nutrition 22:255-266 ( (Sept.) ) 1941;.
McClure, F. J.:  Effect of Fluoride on Rat Caries and on Composition of Rat's Teeth , J. Nutrition 22:391-398 ( (Oct.) ) 1941;.
Bibby, B. G., and Van Kesteren. M.:  The Effect of Fluorine on Mouth Bacteria , J. Dent. Res. 19:391-402 ( (Aug.) ) 1940;.
Harrison, R. W.:  Bacterial Flora in Experimental Dental Caries of the Rat , Proc. Soc. Exper. Biol. & Med. 39:459-461 ( (Dec.) ) 1938;.
Volker, J. F.; Hodge, H. C.; Wilson, H. J., and Van Voorhis, S. N.:  The Adsorption of Fluorides by Enamel, Dentin, Bone and Hydroxyapatite as Shown by the Radioactive Isotope , J. Biol. Chem. 134:543-548 ( (July) ) 1940;.
Perry, Mabel W., and Armstrong, W. D.:  On the Manner of Acquisition of Fluorine by Mature Teeth , J. Nutrition 21:35-44 ( (Jan.) ) 1941;.
Norvold, R. W.; Inglis, J. H., and Armstrong, W. D.:  External Acquisition of Fluorine by Enamel , J. Dent. Res. 20:232-233 ( (June) ) 1941;, Proc.
McClure, F. J.:  Fluorine Acquired by Mature Dog's Teeth , Science 95:256 ( (March 6) ) 1942;.
Volker, J. F.:  Effect of Fluorine on Solubility of Enamel and Dentin , Proc. Soc. Exper. Biol. & Med. 42:725-727 ( (Dec.) ) 1939;
 Solubility of Fluorosed Enamel and Dentin , VolkerProc. Soc. Exper. Biol. & Med. 43:643-645 ( (April) ) 1940;.
Arnold, F. A., Jr., and McClure, F. J.:  Observations on Induced Dental Caries in Rats: II. The Effect of Subcutaneous Injection of Fluoride , J. Dent. Res. 20:457-463 ( (Oct) ) 1941;.
Cheyne, V. D.: J. Am. Dent. A. 29:804-807 ( (May) ) 1942;.
Sharpless, G. R., and McCollum, E. V.:  Is Fluorine an Indispensable Element in the Diet? J. Nutrition 6:163-178 ( (March) ) 1933;.
Evans, R. J., and Phillips, P. H.:  A New Low Fluorine Diet and Its Effect on the Rat , J. Nutrition 18:353-360 ( (Oct.) ) 1939;.
Robinson, W. O.:  Determination of Selenium in Wheat and Soils , J. A. Off. Agr. Chem. 16:423-424, 1933;.
Franke, K. W.:  A New Toxicant Occurring Naturally in Certain Samples of Plant Foodstuffs. I. Results Obtained in Preliminary Feeding Trials , J. Nutrition 8:597-608 ( (Nov.) ) 1934;.
Moxon, A. L.: Alkali Disease or Selenium Poisoning , Bull. 311. South Dakota Agr. Exper. Sta., (May) 1937;. pp. 1-91.
Franke, K. W., and Painter, E. P.:  Selenium in Proteins from Toxic Foodstuffs: 1. Remarks on the Occurrence and Nature of the Selenium Present in a Number of Foodstuffs or Their Derived Products , Cereal Chem. 13:67-70 ( (Jan.) ) 1936;.
Jones, D. B.; Horn, M. J., and Gersdorff, C. E. F.:  The Selenium and Cystine Contents of Some Partial Hydrolysis Products of Gluten from Toxic Wheat , Cereal Chem. 14:130-134 ( (Jan.) ) 1937;.
Trealease, S. F.:  Bad Earth , Scient. Month. 54:13-28 ( (Jan.) ) 1942;.
Moxon.174 Smith, Lillie, Stohlman and Westfall.179
Franke, K. W., and Tully, W. C.:  A New Toxicant Occurring Naturally in Certain Samples of Plant Foodstuffs: V. Low Hatchability Due to Deformities in Chicks , Poultry Sc. 14:273-279, 1935;.
Franke, K. W.; Moxon, A. L.; Foley, W. E., and Tully, W. C.:  Monstrosities Produced by the Injection of Selenium Salts into Hen's Eggs , Anat. Rec. 65:15-22 ( (April) ) 1936;.
Smith, M. I.; Lillie, R. D.; Stohlman, E. F., and Westfall, B. B.: Studies in Chronic Selenosis , Bull., 174, Nat. Inst. Health, 1940;.
Smith, M. I.:  The Influence of Diet on the Chronic Toxicity of Selenium , Pub. Health Rep. 54:1441-1453 ( (Aug. 4) ) 1939;
Lewis, H. B.; Schultz, J., and Gortner, R. A., Jr.:  Dietary Protein and the Toxicity of Sodium Selenite in the White Rat , J. Pharmacol. & Exper. Therap. 68:292-299 ( (Feb.) ) 1940;.
Wright, C. I.:  The Effect of Sodium Selenite and Selenate on the Oxygen Consumption of Mammalian Tissues , Pub. Health Rep. 53:1825-1836 ( (Oct. 14) ) 1938;
 Effect of Selenium on Urease and Arginase , J. Pharmacol. & Exper. Therap. 68:220-230 ( (Feb.) ) 1940;.
Smith, M. T.; Franke, K. W., and Westfall, B. B.:  Selenium Problem in Relation to Public Health: Preliminary Survey to Determine Possibility of Selenium Intoxication in the Rural Population Living on Seleniferous Soil , Pub. Health Rep. 51:1496-1505 ( (Oct. 30) ) 1936;.
Smith, M. I., and Westfall, B. B.:  Further Field Studies on the Selenium Problem in Relation to Public Health , Pub. Health Rep. 52:1375-1384 ( (Oct. 1) ) 1937;.
Sterner, J. H., and Lidfeldt, Viola:  The Selenium Content of "Normal" Urine , J. Pharmacol. & Exper. Therap. 73:205-211 ( (Oct.) ) 1941;.
Smith, M. I.:  Chronic Endemic Selenium Poisoning , J. A. M. A. 116:562-567 [ (Feb. 15) ] 1941;
Dudley, H. C.:  Selenium as a Potential Industrial Hazard , Pub. Health Rep. 53:281-292 [ (Feb. 25) ] 1938;
Bertrand, G., and Aqulhon, H.:  Sur la présence normale du bore chez les animaux , Compt. rend. Acad. d. sc. 155:248-251, 1912;.
Yue, Pao Sen: The Biological Distribution of Boron, dissertation, Johns Hopkins University, May 1937.
Hove, E.; Elvehjem, C. A., and Hart, E. B.:  Boron in Animal Nutrition , Am. J. Physiol. 127:689-701 ( (Nov.) ) 1939;.
Wright and Papisch.9 Blumberg and Rask.9 Drea: Spectrum Analysis for Trace Elements in the Ashes of Human, Goat and Cow Milk.9
Drea, W. F.:  Spectrum Analysis of Hen Eggs and Chick Tissues , J. Nutrition 10:351-355 ( (Oct.) ) 1935;.
Kent, N. L., and McCance, R. A.:  The Absorption and Excretion of "Minor" Elements by Man: 1. Silver, Gold, Lithium, Boron and Vanadium , Biochem. J. 35:837-844 ( (July) ) 1941;.
Orent-Keiles, E.:  The Role of Boron in the Diet of the Rat , Proc. Soc. Exper. Biol. & Med. 44:199-202 ( (May) ) 1940;.
McCollum, E. V.; Rask, O. S., and Becker, J. E.:  A Study of the Possible Role of Aluminum Compounds in Animal and Plant Physiology , J. Biol. Chem. 77:753-768, 1928;.
Myers, V. C., and Mull, J. W.:  The Influence of the Administration of Aluminum on the Aluminum Content of the Tissues and on the Growth and Reproduction of Rats , J. Biol. Chem. 78:605-613, 1928;.
Mackenzie, K.:  Excretion and Absorption of Aluminum in the Pig , Biochem. J. 24:1433-1441, 1930;
 Excretion and Absorption of Aluminum in the Rat , MackenzieBiochem. J. 25:287-291, 1931;.
Wührer, J.:  Zur Frage der Resorption von Aluminium im Organismus, mit Berücksichtigung des normalen Aluminiumgehalts tierischer Gewebe , Biochem. Ztschr. 265:169-180, 1933;.
Burn, J. H.: Aluminium and Foods , Res. Rep. Ext. Ser. 162 Brit. Non-Ferrous Metals Res. Assn., (April) 1932;, p. 1-29.
Beal, G. D.: Unangst, R. B.; Wigman, H. B., and Cox, G. J.:  Aluminum Content of Foodstuffs Cooked in Aluminum and in Glass , Indust. & Engin. Chem. 24:405-407 ( (April) ) 1932;.
Monier-Williams, G. W.: Aluminum in Food , Reports on Public Health and Medical Subjects 78, London, Ministry of Health, 1935;.
Hove, E.; Elvehjem, C. A., and Hart, E. B.:  Aluminum in the Nutrition of the Rat , Am. J. Physiol. 123:640-643 ( (Sept.) ) 1938;.
Scoular, Florence I.:  A Quantitative Study by Means of Spectrographic Analysis of Aluminum in Nutrition , J. Nutrition 17:393-405 ( (April) ) 1939;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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McCollum, E. V.; Orent-Keiles, E., and Day, H. G.: The Newer Knowledge of Nutrition , New York, Macmillan Company, 1939;,  chapter 11 .
Shohl, A. T.: Mineral Metabolism , New York, Reinhold Publishing Corporation, 1939;.  chapter 11 .
Underwood, E. J.:  The Significance of the "Trace Elements" in Nutrition , Nutrition Abstr. & Rev. 9:515-534 ( (Jan.) ) 1940;.
Godden. W.:  "Trace" Elements in Human and Animal Nutrition , J. Soc. Chem. Ind. 58:791-796 ( (Aug.) ) 1939;.
Baumann, E.:  Ueber das normale Vorkommen von Jod im Thierkörper , Ztschr. f. physiol. Chem. 21:319-330, 1895;-1896.
Harless, E.:  Ueber das blaue Blut einiger wirbellosen Thiere und dessen Kupfergehalt , Müller's Arch. Anat. Physiol. , 1847;, pp. 148-156.
Frédéricq, L.:  Sur l'hémocyanine, substance nouvelle du sang du poulpe , Comp. rend. Acad. d. sc. 87:996, 1878;.
Mendel, L. B., and Bradley, H. C.:  Experimental Studies on the Physiology of the Mollusks, Third Paper , Am. J. Physiol. 17:167-176, 1906;.
Henze, M.:  Untersuchungen über das Blut der Ascidien: I. Vanadiumverbindung der Blutkörperchen , Ztschr. f. physiol. Chem. 72:494-501, 1911;.
Griffiths, A. B.: Compt. rend. Acad. d. sc. 114:840, 1892;
von Oettingen: Physiol. Rev. 15:175-201 ( (April) ) 1935;.
Dutoit, P., and Zbinden, C.:  Analyse spectrographique des cendres de sang et d'organes , Compt. rend. Acad. d. sc. 188:1628-1629 ( (June) ) 1929;.
Sheldon, J. H., and Ramage, H.:  A Spectrographic Analysis of Human Tissues , Biochem. J. 25:1608-1627, 1931;.
Rusoff, L. L., and Gaddum, L. W.:  The Trace Element Content of the Newborn Rat (as Determined Spectrographically) , J. Nutrition 15:169-176 ( (Feb.) ) 1938;.
Wright, N. C., and Papish, J.:  The Inorganic Constituents of Milk , Science 69:78 ( (Jan. 18) ) 1929;.
Blumberg, H., and Rask, O. S.:  Spectrographic Analysis of Milk Ashes , J. Nutrition 6:285-288 ( (May) ) 1933;.
Drea, W. F.:  Spectrum Analysis of Milk Ashes , J. Nutrition 8:229-234 ( (Aug.) ) 1934;
 Spectrum Analysis for Trace Elements in the Ashes of Human, Goat and Cow Milk , DreaJ. Nutrition 16:325-331 ( (Oct.) ) 1938;.
Dingle, H., and Sheldon, J. H.:  A Spectrographic Examination of the Mineral Content of Human and Other Milk , Biochem. J. 32:1078-1086, 1938;.
Orent and McCollum.12 Kemmerer, Elvehjem and Hart.13
McCarrison, R.:  Effect of Manganese on Growth , Indian J. M. Res. 14:641-648 ( (Jan.) ) 1927;.
Levine, V. E., and Sohm, H. A.:  The Effect of Manganese on Growth , J. Biol. Chem. 59:xlviii, 1924;.
McHargue, J. S.:  Further Evidence That Small Quantities of Copper. Manganese and Zinc Are Factors in the Metabolism of Animals , Am. J. Physiol. 77:245-255 ( (July) ) 1926;.
Orent, E. R., and McCollum, E. V.:  Effects of Deprivation of Manganese in the Rat , J. Biol. Chem. 92:651-678 ( (Aug.) ) 1931;.
Kemmerer, A. R.; Elvehjem, C. A., and Hart, E. B.:  Studies on the Relation of Manganese to the Nutrition of the Mouse . J. Biol. Chem. 92:623-630 ( (Aug.) ) 1931;.
Daniels, Amy L., and Everson, Gladys, J.:  The Relation of Manganese to Congenital Debility , J. Nutrition 9:191-203 ( (Feb.) ) 1935;.
Shils, M. E., and McCollum, E. V., to be published.
Boyer, P. D.; Shaw, J. J., and Phillips, P. H.:  Studies on Manganese Deficiency in the Rat , J. Biol. Chem. 143:417-425 ( (April) ) 1942;.
Wilgus, H. S., Jr.; Norris, L. C., and Heuser, G. F.:  The Role of Manganese and Certain Other Trace Elements in the Prevention of Perosis , J. Nutrition 14:155-167 ( (Aug.) ) 1937;.
Gallup, W. D., and Norris, L. C.:  Essentialness of Manganese for Normal Development of Bone , Science 87:18-19 ( (Jan. 7) ) 1938;.
Caskey, C. D.; Gallup, W. D., and Norris, L. C.:  The Need for Manganese in the Bone Development of the Chick , J. Nutrition 17:407-417 ( (May) ) 1939;.
Wilgus, H. S., Jr., and Patton, A. R.:  Factors Affecting Manganese Utilization in the Chick , J. Nutrition 18:35-45 ( (July) ) 1939;.
Lyons, M., and Insko, W. M., Jr.:  Chondrodystrophy in the Chick Embryo Produced by a Mineral Deficiency in the Diet of the Hen , Poultry Sc. 16:365-366 ( (Sept.) ) 1937;.
Norris, L. C., and Caskey, C. D.:  A Chronic Congenital Ataxia and Osteodystrophy in Chicks Due to Manganese Deficiency , J. Nutrition 17:16-17, 1939;, Proc.
Caskey, C. D., and Norris, L. C.:  Micromelia in Adult Fowl Caused by Manganese Deficiency During Embryonic Development , Proc. Soc. Exper. Biol. & Med. 44:332-335 ( (June) ) 1940;.
Caskey, C. D., and Norris, L. C.:  Further Studies on the Role of Manganese in Poultry Nutrition , Poultry Sc. 17:433, 1938;, Proc.
Barnes, L. L.; Sperling, G., and Maynard, L. A.:  Bone Development in the Albino Rat on a Low Manganese Diet , Proc. Soc. Exper. Biol. & Med. 46:562-565 ( (April) ) 1941;.
Miller, R. C.; Keith, T. B.; McCarty, M. A., and Thorp, W. T. S.:  Manganese as a Possible Factor Influencing the Occurrence of Lameness in Pigs , Proc. Soc. Exper. Biol. & Med. 45:50-51 ( (Oct.) ) 1940;.
Lyons, M.; Insko, W. M., Jr., and Martin, J. H.:  The Effect of Intraperitoneal Injections of Manganese, Zinc, Aluminum and Iron Salts on the Occurrence of Slipped Tendon in Chicks , Poultry Sc. 17:12-16 ( (Jan.) ) 1938;
 The Effect of Manganese, Zinc, Aluminum and Iron Salts on the Incidence of Perosis in Chicks , LyonsPoultry Sc. 17:264-269 ( (July) ) 1938;.
Jukes, T. H.:  Effect of Choline and Other Supplements on Perosis , J. Nutrition 20:445-458 ( (Nov.) ) 1940;.
Jukes, T. H., and Bird, F. H.:  Prevention of Perosis by Biotin , Proc. Soc. Exper. Biol. & Med. 49:231-232 ( (Feb.) ) 1942;.
Combs, G. F.; Norris, L. C., and Heuser, G. F.:  The Interrelationship of Manganese, Phosphatase, and Vitamin D in Bone Development , J. Nutrition 23:131-140 ( (Feb.) ) 1942;.
Ghormley, R. K., and Fairchild, R. D.:  The Diagnosis and Treatment of Slipped Epiphyses , J. A. M. A. 114:229-235 ( (Jan. 20) ) 1940;.
Perla and Sandberg.28 Sandberg, Perla and Holly.29
Perla, D., and Sandberg, M.:  Metabolic Interdependence of Vitamin B1 and Manganese: Reciprocal Neutralization of Their Toxic Effects , Proc. Soc. Exper. Biol. & Med. 41:522-527 ( (June) ) 1939;.
Sandberg, M.; Perla, D., and Holly, O. M.:  Interdependence of Vitamin B1 and Manganese; Manganese, Copper and Iron Metabolism in B1 Deficient Rats , Proc. Soc. Exper. Biol. & Med. 42:368-371 ( (Nov.) ) 1939;.
Collison, R. C.: Minor Elements and Crop Fertilization, New York (Geneva) Agr. Expt. Sta. Circ. 168, 1937, pp. 1-13.
Steinberg, R. A.:  Growth of Fungi in Synthetic Nutrient Solutions , Botan. Rev. 5:327-350 ( (June) ) 1939;.
Woolley, D. W.:  Manganese and the Growth of Lactic Acid Bacteria , J. Biol. Chem. 140:311-312 ( (July) ) 1941;.
Everson, Gladys J., and Daniels, Amy L.:  A Study of Manganese Retentions in Children , J. Nutrition 8:497-502 ( (Nov.) ) 1934;.
Macy, Icie G.: Nutrition and Chemical Growth in Childhood , Springfield, Ill., Charles C. Thomas, 1942;, vol 1,  Evaluation, chapter 3 .
Kehoe, R. A.; Cholak, J., and Story, R. V.:  Manganese, Lead, Tin, Aluminum, Copper and Silver in Normal Biological Material , J. Nutrition 20:85-98 ( (July) ) 1940;.
Remington, R. E., and Shiver, H. E.:  Iron, Copper and Manganese Content of Some Common Vegetables , J. A. Off. Agr. Chem. 13:129-132, 1930;.
Hodges, Mildred A., and Peterson. W. H.:  Manganese, Copper and Iron Content of Serving Portions of Common Foods , J. Am. Dietet. A. 7:6-16 ( (June) ) 1931;.
Lindow, C. W., and Peterson, W. H.:  The Manganese Content of Plant and Animal Materials , J. Biol. Chem. 75:169-175 ( (Oct.) ) 1927;.
Peterson. W. H., and Skinner, J. T.:  Distribution of Manganese in Foods , J. Nutrition 4:419-426 ( (Sept.) ) 1931;.
Kehoe, R. A.; Cholak, J., and Story, R. V.:  Spectrochemical Study of the Normal Ranges of Concentration of Certain Trace Metals in Biological Materials , J. Nutrition 19:579-592 ( (June) ) 1940;.
Ramage, H.; Sheldon, J. H., and Sheldon, W.:  A Spectrographic Investigation of the Metallic Content of the Liver in Childhood , Proc. Roy. Soc. 113:308-327 ( (Aug.) ) 1933;.
Gruzewska, Z. (Mme.), and Roussel, G.:  Le manganèse dans le foie foetal au cours de son développement , Bull. Soc. chim. biol. 21:730-736 ( (May) ) 1939;.
Skinner, J. T.; Peterson, W. H., and Steenbock, Harry:  The Manganese Metabolism of the Rat , J. Biol. Chem. 90:65-80 ( (Jan.) ) 1931;.
Greenberg, D. M., and Campbell, W. W.:  Studies in Mineral Metabolism with the Aid of Induced Radioactive Isotopes: IV. Manganese , Proc. Nat. Acad. Sc. 26:448-452 ( (July) ) 1940;.
Hart, E. B.; Steenbock, Harry; Waddell, J., and Elvehjem, C. A.:  Iron in Nutrition: Copper as a Supplement to Iron for Hemoglobin Building in the Rat , J. Biol. Chem. 77:797-812 ( (May) ) 1928;.
Titus, R. W.; Cave, H. W., and Hughes, J. S.:  Manganese-Copper-Iron Complex as a Factor in Hemoglobin Building , J. Biol. Chem. 80:565-570 ( (Dec.) ) 1928;.
Myers, V. C., and Beard, H. H.:  The Influence of Inorganic Elements on Blood Regeneration in Nutritional Anemia , J. A. M. A. 93:1210-1212 ( (Oct. 19) ) 1929;.
Elvehjem, C. A.:  Biological Significance of Copper and Its Relatiton to Iron Metabolism , Physiol. Rev. 15:471-507 ( (July) ) 1935;.
von Oettingen, W. F.:  Manganese: Its Distribution, Pharmacology and Health Hazards , Physiol. Rev. 15:175-201 ( (April) ) 1935;.
Bertrand, G.:  Sur l'intervention du manganèse dans les oxydations provoqués par la laccase , Compt. rend. Acad. d. sc. 124:1032-1035, 1897;.
Keilin, D., and Mann, T.:  Laccase, a Blue Copper-Protein Oxidase from the Latex of Rhus Succedanea , Nature 143:23 ( (Jan. 7) ) 1939;.
Wiese, A. C.; Johnson, B. C.; Elvehjem, C. A.; Hart, E. B., and Halpin, J. G.:  A Study of Blood and Bone Phosphatase in Chick Ferosis , J. Biol. Chem. 127:411-420 ( (Feb.) ) 1939;.
Wiese, A. C.; Benham, G. H.; Elvehjem, C. A., and Hart, E. B.:  Further Bone Phosphatase Studies in Chick Perosis , Poultry Sc. 20:255-258 ( (May) ) 1941;.
Bamann, E., and Heumüller, E.:  Ueber die Aktivierung von Phosphatasen durch verschiedene Metall-Ionen , Naturwissensch. 28:535 ( (Aug. 16) ) 1940;.
Massart, L., and Dufait, R.:  Fluoridhemmung und Metallaktivierung der Hefephosphatase , Naturwissensch. 27:806-807 ( (Dec. 1) ) 1939;.
Cloetens, R.:  Aktivierung und Hemmung der alkalischen Phosphatasen , Naturwissensch. 27:806 ( (Dec. 1) ) 1939;.
Krebs, H. A., and Henseleit, K.:  Untersuchungen über die Harnstoffbildung im Tierkörper , Ztschr. f. physiol. Chem. 210:33-66, 1932;.
Edlbacher, S., and Pinösch, H.:  Ueber die Natur der Arginase , Ztschr. f. physiol. Chem. 250:241-248, 1937;.
Richards, Marianna M., and Hellerman, L.:  Purified Liver Arginase; Reversible Inactivation and Reactivation , J. Biol. Chem. 134:237-252 ( (June) ) 1940;.
Shils and McCollum.15 Boyer, Shaw and Phillips.15a
Cori, G. T.; Colowick, S. P., and Cori, C. F.:  The Enzymatic Conversion of Glucose-1-phosphoric Ester to 6-ester in Tissue Extracts , J. Biol. Chem. 124:543-555 ( (July) ) 1938;.
Berger, J., and Johnson, M. J.:  Metal Activation of Peptidases , J. Biol. Chem. 130:641-654 ( (Oct.) ) 1939;.
Smith, E. L., and Bergmann, M.:  The Activation of Intestinal Peptidases by Manganese , J. Biol. Chem. 138:789-790 ( (April) ) 1941;.
Massart, L., and Dufait, R.:  Activations et inhibitions de la cholinesterase , Enzymologia 6:282-286, 1939;.
Nachmansohn, D.:  Action of Ions on Choline Esterase , Nature 145:513-514 ( (March 30) ) 1940;.
Ohlmeyer, P., and Ochoa, S.:  Ueber die Rolle des Mangans für die Phosphat übertragende Funktion der Cozymase , Naturwissensch. 25:253 ( (April 16) ) 1937;.
Adler, E.; von Euler, H.; Günther, G., and Plass, M.:  Isocitric Dehydrogenase and Glutamic Acid Synthesis in Animal Tissues , Biochem. J. 33:1028-1045, 1939;.
Green, D. E.; Herbert, D., and Subrahmanyan, V.:  Carboxylase , J. Biol. Chem. 138:327-339 ( (March) ) 1941;
Green, D. E.; Westerfeld, W. W.; Vennesland, B., and Knox, W. E.:  Pyruvic and Ketoglutaric Carboxylases of Animal Tissues , J. Biol. Chem. 140:683-684 ( (Aug.) ) 1941;.
Engelhardt, W. A., and Liubimowa, M. N.:  Myosine and Adenosinetriphosphatase , Nature 144:668-669 ( (Oct. 14) ) 1939;.
Bailey, K.:  Myosin and Adenosinetriphosphatase , Biochem. J. 36:121-139 ( (Feb.) ) 1942;.
Rudra, M. N.:  Role of Manganese in the Biological Synthesis of Ascorbic Acid , Nature 144:868 ( (Nov. 18) ) 1939;.
Orent and McCollum.12 Kemmerer, Elvehjem and Hart.13 Daniels and Everson.14 Shils and McCollum.15 Boyer, Shaw and Phillips.15a
Footnote deleted on proof.
Ahmad, B., and McCollum, E. V.:  The Cobalt Content of Some Food Materials from Different Parts of the United States , Am. J. Hyg. 29:24-26 ( (Jan.) ) 1939;.
Copp, D. H., and Greenberg, D. M.:  Studies in Mineral Metabolism with the Aid of Artificial Radioactive Isotopes: VI. Cobalt , Proc. Nat. Acad. Sc. 27:153-157 ( (March) ) 1941;.
Kent, N. L., and McCance, R.:  The Absorption and Excretion of "Minor" Elements by Man: 2. Cobalt, Nickel, Tin and Manganese , Biochem. J. 35:877-883 ( (Sept.) ) 1941;.
Bertrand, G.:  The Importance of Minute Chemical Constituents of Biological Products: Nickel, Cobalt and Insulin , Science 64:629-630 ( (Dec. 26) ) 1926;.
Blatherwick, N. R., and Sahyun, M.:  The Effect of Cobalt on Insulin Hypoglycemia in Rabbits , Am. J. Physiol. 81:560-562 ( (Aug.) ) 1927;.
Magenta, M. A.:  Action des sels de nickel et de cobalt sur l'hypoglycémie insulinique , Compt. rend. Soc. de biol. 98:169-170 ( (Jan. 20) ) 1928;.
Scott, D. A., and Fisher, A. M.:  The Effect of Zinc Salts on the Action of Insulin , J. Pharmacol. & Exper. Therap. 55:206-221 ( (Oct.) ) 1935;.
Waltner. Klara, and Waltner, K.:  Kobalt und Blut , Klin. Wchnschr. 8:313 ( (Feb. 12) ) 1929;.
Stare, F. J., and Elvehjem, C. A.:  Cobalt in Animal Nutrition , J. Biol. Chem. 99:473-483 ( (Jan.) ) 1933;.
Orten, J. M.; Underhill, F. A.; Mugrage, E. R., and Lewis, R. C.:  Polycythemia in the Rat on a Milk-Iron-Copper Diet Supplemented by Cobalt , J. Biol. Chem. 96:11-16 ( (April) ) 1932;.
Mascherpa, P.:  Le pouvoir hématopoietique du cobalt , Arch. ital. de Biol. 82:112-120, 1930;.
Kleinberg, W.; Gordon, A. S., and Charipper, H. A.:  Effect of Cobalt on Erythropoiesis in Anemic Rabbits , Proc. Soc. Exper. Biol. & Med. 42:119-120 ( (Oct.) ) 1939;.
Orten, J. M.:  On the Mechanism of the Hematopoietic Action of Cobalt , Am. J. Physiol. 114:414-422 ( (Jan.) ) 1936;.
Davis, J. E.:  The Effect of Ascorbic Acid Administration on Experimental Polycythemias: The Mechanism of Cobalt Polycythemia , Am. J. Physiol. 129:140-145 ( (April) ) 1940;.
Orten, J. M.; Underhill, F. M.; Mugrage, E. R., and Lewis, R. C.:  The Effect of Manganese on Cobalt Polycythemia , J. Biol. Chem. 99:465-468 ( (Jan.) ) 1933;.
Barron, A. G., and Barron, E. S. G.:  Mechanism of Cobalt Polycythemia: Effect of Ascorbic Acid , Proc. Soc. Exper. Biol. & Med. 35:407-409 ( (Dec.) ) 1936;.
Davis, J. E.:  Depression of Experimental Polycythemia by Choline Hydrochloride or Liver Administration , Am. J. Physiol. 127:322-327 ( (Sept.) ) 1939;
 The Depression of Experimental Polycythemias by Various Substances in Dogs, Rabbits and Man , J. Pharmacol. & Exper. Therap. 73:162-169 ( (Oct.) ) 1941;.
Anderson, H. D.; Underwood, E. J., and Elvehjem, C. A.:  Factors Affecting the Maintenance of Cobalt Polycythemia in the Rat , Am. J. Physiol. 130:373-378 ( (Aug.) ) 1940;.
Griffith, W. H.; Pavcek, P. L., and Mulford, D. J.:  The Relation of the Sulfur Amino Acids to the Toxicity of Cobalt and Nickel in the Rat , J. Nutrition 23:603-612 ( (June) ) 1942;.
Frost, D. V.; Spitzer, E. H.; Elvehjem, C. A., and Hart, E. B.:  Some Effects of Cobalt and Liver Substance on Blood Building in Dogs , Am. J. Physiol. 134:746-754 ( (Nov.) ) 1941;.
Filmer, J. F., and Underwood, E. J.:  Enzootic Marasmus: Further Data Concerning the Potency of Cobalt as a Curative and Prophylactic Agent , Australian Vet. J. 13:57-64, 1937;.
Schultze, M. O.:  The Relation of Copper to Cytochrome Oxidase and Hematopoietic Activity of the Bone Marrow of Rats , J. Biol. Chem. 138:219-224 ( (March) ) 1941;.
Underwood, E. J.:  The Significance of the "Trace Elements" in Nutrition , Nutrition Abstr. & Rev. 9:515-534 ( (Jan.) ) 1940;.
Underwood, E. J.:  Enzootic Marasmus Iron Content of Liver, Kidney and Spleen , Australian Vet. J. 10:87-92, 1934;.
Filmer, J. F., and Underwood, E. J.:  Enzootic Marasmus: Treatment with Limonite Fractions , Australian Vet. J. 10:83-87, 1934;.
Marston, H. R.:  Problems Associated with "Coast Disease" in South Australia , Comm. Austral. J. Counc. Sc. Ind. Res. 8:111-116 ( (May) ) 1935;.
Lines, E. W.:  The Effect of the Ingestion of Minute Quantities of Cobalt by Sheep Affected with "Coast Disease": A Preliminary Note , Comm. Austral. J. Counc. Sc. Ind. Res. 8:117 ( (May) ) 1935;.
Underwood, E. J., and Filmer, J. F.:  The Determination of the Biologically Potent Element Cobalt in Limonite , Australian Vet. J. 11:84-92, 1935;.
Askew, H. O., and Dixon, J. K.:  The Importance of Cobalt in the Treatment of Certain Stock Ailments in the South Island, New Zealand , New Zealand J. Sc. Technol. 18:73-84 ( (July) ) 1936;.
Neal, W. M., and Ahmann, C. F.:  The Essentiality of Cobalt in Bovine Nutrition , J. Dairy Sc. 20:741-753, 1937;.
Ann. Repts. Dept. Agr. Kenya 1936, 1937
Corner, H. H., and Smith, A. M.:  The Influence of Cobalt on Pine Disease in Sheep , Biochem. J. 32:1800-1805 ( (Oct.) ) 1938;.
Bowstead, J. E., and Sackville, J. P.:  Studies with a Deficient Ration for Sheep: 2. Effects of Cobalt Supplement , Canad. J. Res. D. 17:15, 1939;
Nutrition Abstr. & Rev. 9:241, 1939;.
Balzer, A. C.; Killham, B. J.; Duncan, C. W., and Huffman, C. F.:  Cobalt Deficiency Disease Observed in Some Michigan Dairy Cattle , Michigan Agri. Exper. Sta. Quart. Bull. 24:68-70 ( (Aug.) ) 1941;.
Marston, H. R.; Lines, E. W.; Thomas, R. G., and McDonald, I. W.:  Cobalt and Copper in Ruminant Nutrition , Nature 141:398-400 ( (March 5) ) 1938;.
Underwood, E. J., and Elvehjem, C. A.:  Is Cobalt of Any Significance in the Treatment of Milk Anemia with Iron and Copper? J. Biol. Chem. 124:419-424 ( (July) ) 1938;.
Frost, D. V.; Elvehjem, C. A., and Hart, E. B.:  A Study of the Need for Cobalt in Dogs on Milk Diets , J. Nutrition 21:93-100 ( (Jan.) ) 1941;.
Kato, K.:  Iron-Cobalt Treatment of Physiologic and Nutritional Anemia in Infants , J. Pediat. 11:385-396 ( (Sept.) ) 1937;.
Baxter, C. R.:  Copper and Cobalt in Anemia , Brit. M. J. 1:534-535 ( (March 11) ) 1939;.
Cronin, E.:  Copper and Cobalt in Anemia , Brit. M. J. 1:643 ( (March 25) ) 1939;.
Waltner, K.:  Therapeutische Versuche mit Kobalt , Acta pediat. 11:438-440 ( (Aug.) ) 1930;.
See section on manganese.
Bertrand, G., and Benzon, B.:  Sur l'importance du zinc dans l'alimentation des animaux: Expériences sur la souris , Comp. rend. Acad. d. sc. 175:289-292, 1922;.
McHargue, J. S.:  Further Evidence That Small Quantities of Copper, Manganese and Zinc Are Factors in the Metabolism of Animals , Am. J. Physiol. 77:245-255 ( (July) ) 1926;.
Hubbell, Rebecca B., and Mendel, L. B.:  Zinc and Normal Nutrition. J. Biol. Chem. 75:567-586, 1927;.
Bertrand, G., and Bhattacherjee, R. C.:  L'action combinée du zinc et des vitamines dans l'alimentation des animaux , Comp. rend. Acad. d. sc. 198:1823-1827 ( (May 23) ) 1934;.
Todd, W. R.; Elvehjem, C. A., and Hart, E. B.:  Zinc in the Nutrition of the Rat , Am. J. Physiol. 107:146-156 ( (Jan.) ) 1934;.
Stirn, F. E.; Elvehjem, C. A., and Hart, E. B.:  The Indispensability of Zinc in Nutrition of the Rat , J. Biol. Chem. 109:347-359 ( (April) ) 1935;.
Hove, E.; Elvehjem, C. A., and Hart, E. B.:  The Physiology of Zinc in the Nutrition of the Rat; 122 Further Studies on Zinc Deficiency in Rats , Am. J. Physiol. 124:750-758 ( (Dec.) ) 1938;.
Day, H. G., and McCollum, E. V.:  Effects of Acute Dietary Zinc Deficiency in the Rat , Proc. Soc. Exper. Biol. & Med. 45:282-284, 1940;.
Day, H. G.:  The Effects of Zinc Deficiency in the Mouse , Federation Proc. 1:188-189 ( (March) ) 1942;.
Follis, R. H., Jr., and Day, H. G.:  Histological Studies of the Tissues of Rats Fed a Diet Extremely Low in Zinc , J. Nutrition 22:223-237 ( (Sept.) ) 1941;.
Bessey, O. A., and Wolbach, S. B.:  Vascularization of the Cornea of the Rat in Riboflavin Deficiency with a Note on Corneal Vascularization in Vitamin A deficiency , J. Exper. Med. 69:1-12 ( (Jan.) ) 1939;.
Scott, D. A.:  Crystalline Insulin , Biochem. J. 28:1592-1602, 1934;.
Scott, D. A., and Fisher, A. M.:  Crystalline Insulin , Biochem. J. 29:1048-1054, 1935;.
Cohn, E. J.; Ferry, J. D.; Livingood, J. J., and Blanchard, M. H.:  The Solubility and Dielectric Properties of Insulin and Its Crystallization with Radioactive Zinc , Science 90:183-185 ( (Aug. 25) ) 1939;.
Bischoff, F., and Jemtegaard, L. M.:  Divided Dosage of Insulin , Am. J. Physiol. 119:149-152 ( (May) ) 1937;.
Blatherwick, N. R.; Ewing, Mary E., and Bradshaw, Phoebe J.:  Some Effects of Zinc and Iron Salts on the Hypoglycemic Action of Insulin in Rats , Am. J. Physiol. 121:44-48 ( (Jan.) ) 1938;.
Scott, D. A., and Fisher, A. M.:  The Insulin and the Zinc Content of Normal and Diabetic Pancreas , J. Clin. Investigation 17:725-728 ( (Nov.) ) 1938;.
Eisenbrand, J., and Sienz, M.:  Ueber den Zinkgehalt von menschlichen Pankreasdrüsen , Ztschr. f. physiol. Chem. 268:1-35 ( (March) ) 1941;.
Roughton, F. J. W.:  Recent Work on the Carbon Dioxide Transport by the Blood , Physiol. Rev. 15:241-296 ( (April) ) 1935;.
Keilin, D., and Mann, T.:  Carbonic Anhydrase , Nature 144:442-443 ( (Sept. 2) ) 1939;.
Hove, E.; Elvehjem, C. A., and Hart, E. B.:  The Relation of Zinc to Carbonic Anhydrase , J. Biol. Chem. 136:425-434 ( (Nov.) ) 1940;.
Scott, D. A., and Mendive, J. R.:  Chemical Observations on Carbonic Anhydrase , J. Biol. Chem. 140:445-451 ( (Aug.) ) 1941;.
Davenport, H. W.:  Gastric Carbonic Anhydrase , J. Physiol. 97:32-43 ( (Nov.) ) 1939;.
van Goor, H.:  La répartition de l'anhydrase carbonique dans l'organisme des animaux , Arch. internat. physiol. 45:491-509 ( (Dec.) ) 1937;.
Tucker, Helen F., and Ball, E. G.:  The Activity of Carbonic Anhydrase in Relation to the Secretion and Composition of Pancreatic Juice , J. Biol. Chem. 139:71-80 ( (May) ) 1941;.
Davenport, H. W., and Wilhelmi, A. E.:  Renal Carbonic Anhydrase , Proc. Soc. Exper. Biol. & Med. 48:53-56 ( (Oct.) ) 1941;.
Keilin and Mann.114 Hove, Elvehjem and Hart.115
Mann, T., and Keilin, D.:  Sulfanilamide as a Specific Inhibitor of Carbonic Anhydrase , Nature 146:164-165 ( (Aug. 3) ) 1940;.
Holmberg, C. G.:  Uricase Purification and Properties , Biochem. J. 33:1901-1906, 1939;.
Davidson, J. N.:  The Purification of Uricase. 2. Some Properties of Purified Uricase , Biochem. J. 36:252-258 ( (Feb.) ) 1942;.
Hove, E.; Elvehjem, C. A., and Hart, E. B.:  The Physiology of Zinc in the Nutrition of the Rat , Am. J. Physiol. 119:768-775 ( (Aug.) ) 1937;.
Hove, Elvehjem and Hart.115 Day and McCollum.104
Wachtel, L. W.; Hove, E.; Elvehjem, C. A., and Hart, E. B.:  Blood Uric Acid and Liver Uricase of Zinc Deficient Rats on Various Diets , J. Biol. Chem. 138:361-368 ( (March) ) 1941;.
Hove, Elias; Elvehjem, C. A., and Hart, E. B.  The Effect of Zinc on Alkaline Phosphatases , J. Biol. Chem. 134:425-442 ( (June) ) 1940;.
Lutz, R. E.:  The Normal Occurrence of Zinc in Biological Materials: A Review of the Literature and a Study of the Normal Distribution of Zinc in the Rat, Cat and Man , J. Indust. Hyg. 8:177-207, 1926;.
Eggleton, W. G. E.:  The Zinc Content of Epidermal Structures in Beriberi , Biochem. J. 33:403-406 ( (April) ) 1939;.
Scoular, Florence I.:  A Quantitative Study, by Means of Spectrographic Analysis, of Zinc in Nutrition , J. Nutrition 17:103-113 ( (Feb.) ) 1939;.
Stern, A.; Naldar, Margaret, and Macy, Icie G.:  Zinc Retention in Childhood , J. Nutrition 21:8, 1941;, Proc.
Macy, Icie G.: Nutrition and Chemical Growth in Childhood , vol. 1, Evaluation, Springfield, Ill., Charles C. Thomas, 1942;.
McClure, F. J.: Fluorides in Food and Drinking Water , Bulletin 172, Nat. Inst. Health, 1939;.
McKay, F. S., in collaboration with Black, G. V.:  An Investigation of Mottled Teeth , Dent. Cosmos 58:477-484 ( (May) ), 627-644 (June) 1916;.
Churchill, H. V.:  Occurrence of Fluorides in Some Waters of the United States , Indust. & Engin. Chem. 23:996-998 ( (Sept.) ) 1931;.
Smith, Margaret C.; Lantz, E. M., and Smith, H. V.: The Cause of Mottled Enamel, a Defect of Human Teeth , Tech. Bull. 32, Univ. Arizona Agr. Exper. Stat., (June) 1931;, pp. 253-282.
Velu, H.:  Dystrophie dentaire des mammifères des zones phosphatées (darmous) et fluorose chronique , Comp. rend. Soc. de biol. 108:750-752 ( (Nov. 21) ) 1931;.
Dean, H. T., and Elvove, E.:  Further Studies on the Minimal Threshold of Chronic Endemic Fluorosis , Pub. Health Rep. 52:1249-1264 ( (Sept. 10) ) 1937;.
Black, G. V., in collaboration with McKay, F. S.:  Mottled Teeth: An Endemic Developmental Imperfection of the Teeth, Heretofore Unknown in the Literature of Dentistry , Dent. Cosmos 58:129-156 ( (Feb.) ) 1916;.
Williams, J. L.:  Mottled Enamel and Other Studies of Normal and Pathological Conditions of This Tissue , J. Dent. Res. 5:117-195, ( (Sept.) ) 1923;.
Beust, T. B.:  A Contribution to the Etiology of Mottled Enamel. J. Am. Dent. A. 12:1059-1066 ( (Sept.) ) 1925;.
Ainsworth, N. J.:  Mottled Teeth , Brit. Dent. J. 55:233-250, 274-276 ( (Sept.) ) 1933;.
Dean, H. T.:  Chronic Endemic Dental Fluorosis (Mottled Enamel) , J. A. M. A. 107:1269-1272 ( (Oct. 17) ) 1936;.
Dean, H. T., and McKay, F. S.:  Production of Mottled Enamel Halted by Change in the Common Water Supply , Am. J. Pub. Health 29:590-596 ( (June) ) 1939;.
Nichols, M. S.:  Occurrence, Pathological Aspects and Treatment of Fluoride Waters , Am. J. Pub. Health 29:991-998 ( (Sept.) ) 1939;.
Dean, H. T.:  Fluorine, Mottled Enamel and Dental Caries , J. Pediat. 16:782-794 ( (June) ) 1940;
Hawkins, J. W., and Gordon, J. E.:  Epidemiological Aspects of Mottled Enamel , Am. J. M. Sc. 199:431-446 ( (March) ) 1940;.
Roholm, K.: Fluorine Intoxication , London, H. K. Lewis Ltd., 1937;.
Greenwood, D. A.:  Fluoride Intoxication , Physiol. Rev. 20:582-616 ( (Oct.) ) 1940;.
McCollum, E. V.; Simmonds, Nina; Becker, J. Ernestine, and Bunting, R. W.:  The Effect of Additions of Fluorine to the Diet of the Rat on the Quality of the Teeth , J. Biol. Chem. 63:553-562 ( (April) ) 1925;.
Schulz, J. A., and Lamb, A. R.:  The Effect of Fluorine as Sodium Fluoride on the Growth and Reproduction of Albino Rats , Science 61:93-94 ( (Jan. 23) ) 1925;.
McCollum, Simmonds, Becker and Bunting.141 Schulz and Lamb.142
Peirce, A. W.:  Chronic Fluorine Intoxication in Domestic Animals , Nutrition Abstr. & Rev. 9:253-261 ( (Oct.) ) 1939;.
Bosworth, T. J.; Green, H. H., and Murray, M. M.:  Discussion on Fluorosis in Man and Animals , Proc. Roy. Soc. Med. 34:391-396 ( (May) ) 1941;.
Morgareidge, K., and Finn, S. B.:  Effect of Fluorine on the Activity of Vitamin D in Rachitic Rats , J. Nutrition 20:75-84 ( (July) ) 1940;.
Finn, B. B., and Kramer, M.:  Effect of Fluorine on Life Span of Rachitic Rats , Proc. Soc. Exper. Biol. & Med. 45:843-845 ( (Dec.) ) 1940;.
Glock, G. E.:  Glycogen and Calcification , J. Physiol. 98:1-11 ( (March) ) 1940;.
Hodges, P. C.; Fareed, O. J.; Ruggy, George, and Chudnof, J. S.:  Skeletal Sclerosis in Chronic Sodium Fluoride Poisoning , J. A. M. A. 117:1938 ( (Dec. 6) ) 1941;.
Smith, Margaret C.:  Fluorine Toxicosis: A Public Health Problem , Am. J. Pub. Health 25:696-702 ( (June) ) 1935;.
Shortt, H. E.; McRobert, G. R.; Barnard, T. W., and Nayar, A. S. M.:  Endemic Fluorosis in the Madras Presidency , Indian J. M. Res. 25:553-568 ( (Oct.) ) 1937;.
DeEds, Floyd:  Factors in the Etiology of Mottled Enamel , J. Am. Dent. A. 28:1804-1814 ( (Nov.) ) 1941;.
Smith, Margaret C., and Lantz, Edith M.:  The Effect of Fluorine on the Phosphatase Content of Plasma, Bones and Teeth of Albino Rats , J. Biol. Chem. 112:303-311 ( (Dec.) ) 1935;.
Ochoa, S.:  "Coupling" of Phosphorylation with Oxidation of Pyruvic Acid in Brain , J. Biol. Chem. 138:751-773 ( (April) ) 1941;.
Massart, L., and Dufait, R.:  Fluoridhemmung und Metallaktivierung der Hefephosphatase , Naturwissensch. 27:806-807 ( (Dec. 1) ) 1939;.
Loevenhart, A. S., and Peirce, G.:  The Inhibiting Effect of Sodium Fluoride on the Action of Lipase , J. Biol. Chem. 2:397-413, 1908;.
Phillips, P. H.; English, H. E., and Hart, E. B.:  The Influence of Sodium Fluoride on the Basal Metabolism of the Rat Under Several Experimental Conditions , Am. J. Physiol. 113:441-449 ( (Oct.) ) 1935;.
Phillips, P. H.; English, H. E., and Hart, E. B.:  The Augmentation of the Toxicity of Fluorosis in the Chick by Feeding Desiccated Thyroid , J. Nutrition 10:399-407 ( (Oct.) ) 1935;.
Wilson, R. H., and DeEds, Floyd:  Synergistic Action of Thyroid on Fluorine Toxicity , Endocrinology 26:851-856 ( (May) ) 1940;.
DeEds, Floyd; Wilson, R. H., and Cutting, W. C.:  Thyrotropic Hormone and Fluorine Activity , Endocrinology 26:1053-1056 ( (June) ) 1940;.
Phillips, P. H.; Hart, E. B., and Bohstedt, G.:  The Influence of Fluorine Ingestion on the Nutritional Qualities of Milk , J. Biol. Chem. 105:123-134 ( (April) ) 1934;.
Smith, Margaret C.; Vavich, M., and Smith, H. V.:  Fluorine Content of Milk as Affected by the Amount of Fluorine in the Drinking Water of the Cow , J. Dent. Res. 20:286-287 ( (June) ) 1941;, Proc.
Brinch, O., and Roholm, K.: Paradentium 6:147, 1934;
Hart, E. B.; Phillips, P. H., and Bohstedt, G.:  Relation of Soil Fertilization with Superphosphate and Rock Phosphate to Fluorine of Plants and Drainage Waters , Am. J. Pub. Health 24:936-940 ( (Sept.) ) 1934;.
Mackle, W.; Scott, E. W., and Treon, J.:  Normal Urinary Fluoride Excretion and the Fluorine Content of Food and Water , Am. J. Hyg. 29:139-145 (sec. A., (May) ) 1939;.
DeEds, F.:  The Toxicity of Fluorine in Dicalcium Phosphate , Am. J. M. Sc. 203:687-692 ( (May) ) 1942;.
Armstrong, W. D.:  Fluorine Content of Enamel and Dentin of Sound and Carious Teeth , Proc. Am. Soc. Biol. Chem., J. Biol. Chem. 119:v, 1937;.
Armstrong, W. D., and Brekhus, P. J.:  Possible Relationship Between the Fluorine Content of Enamel and Resistance to Dental Caries , J. Dent. Res. 17:393-399 ( (Oct.) ) 1938;.
Bunting, R. W.; Crowley, M.; Hard, D. H., and Keller, M.:  Further Studies on Relation of B. Acidophilus to Dental Caries , Dent. Cosmos 70:1002-1009 ( (Oct.) ) 1928;.
McKay, F. S.:  Establishment of Definite Relation Between Enamel That Is Defective in Structure, as Mottled Enamel, and Its Liability to Decay , Dent. Cosmos 71:747-755 ( (Aug.) ) 1929;.
Arnim, S. S.; Aberle, S. D., and Pitney, E. H.:  A Study of Dental Changes in a Group of Pueblo Indian Children , J. Am. Dent. A. 24:478-480 ( (March) ) 1937;.
Masaki, T.; Gakuho Shikwa 26:17, 1931;
Dean, H. T.:  Endemic Fluorosis and Its Relation to Dental Caries , Pub. Health Rep. 53:1443-1452 ( (Aug. 19) ) 1938;.
Dean, H. T.; Jay, P.; Arnold, F. A., Jr.; McClure, F., and Elvove, E.:  Domestic Water and Dental Caries, Including Certain Epidemiological Aspects of Oral L. Acidophilus , Pub. Health Rep. 54:862-888 ( (May 26) ) 1939;.
Dean, H. T.; Jay, P.; Arnold, F. A., Jr., and Elvove, E.:  Domestic Water and Dental Caries: II. A Study of 2,832 White Children, Aged 12 to 14 Years, of Eight Suburban Chicago Communities, Including Lactobacillius Acidophilus Studies of 1,761 Children , Pub. Health Rep. 56:761-792 ( (April 11) ) 1941;.
Dean, H. T.; Jay, P.; Arnold, F. A., Jr., and Elvove, E.:  A Dental Caries Study, Including L. Acidophilus Estimations of a Population Severely Affected by Mottled Enamel and Which for the Past Twelve Years Has Used a Fluoride Free Water , Pub. Health Rep. 56:365-381 ( (Feb. 28) ) 1941;.
Arnold, F. A.; Dean, H. T., and Elvove, E.:  Domestic Water and Dental Caries, IV. Effect of Increasing the Fluoride Content of a Common Water Supply on the Lactobacillus Acidophilus Counts of the Saliva , Pub. Health Rep. 57:773-780 ( (May 22) ) 1942;.
Cox, G. J.: Matuschak, Margaret C.; Dixon, Sara F.; Dodds, Mary L., and Walker, W. E.:  Fluorine and Its Relation to Dental Caries , J. Dent. Res. 18:481-490 ( (Dec.) ) 1939;.
Miller, B. F.:  Inhibition of Experimental Dental Caries in the Rat by Fluoride and Iodoacetic Acid , Proc. Soc. Exper. Biol. & Med. 39:389-393 ( (Nov.) ) 1938;.
Hodge, H. C., and Finn. S. B.:  Reduction in Experimental Rat Caries by Fluorine , Proc. Soc. Exper. Biol. & Med. 42:318-320 ( (Oct.) ) 1939;.
Sognnaes. R. F.:  Effect of Local and Systemic Fluorine Administration on Experimental Rat Caries , J. Dent. Res. 19:287 ( (June) ) 1940;, Proc.
Cheyne, V. D.:  Inhibition of Experimental Dental Caries by Fluorine in the Absence of Saliva , Proc. Soc. Exper. Biol. & Med. 43:58-61 ( (Jan.) ) 1940;
 Study of the Mechanism of Inhibition of Dental Caries by Fluorine , J. Dent. Res. 19:280-281 ( (June) ) 1940;
McClure, F. J., and Arnold, F. A.. Jr.:  Observations on Induced Dental Caries in Rats: Reduction by Fluorides and Iodoacetic Acid . J. Dent. Res. 20:97-105 ( (April) ) 1941;.
Finn, S. B., and Hodge, H. C.:  Reduction in Experimental Caries by Fluorine . J. Nutrition 22:255-266 ( (Sept.) ) 1941;.
McClure, F. J.:  Effect of Fluoride on Rat Caries and on Composition of Rat's Teeth , J. Nutrition 22:391-398 ( (Oct.) ) 1941;.
Bibby, B. G., and Van Kesteren. M.:  The Effect of Fluorine on Mouth Bacteria , J. Dent. Res. 19:391-402 ( (Aug.) ) 1940;.
Harrison, R. W.:  Bacterial Flora in Experimental Dental Caries of the Rat , Proc. Soc. Exper. Biol. & Med. 39:459-461 ( (Dec.) ) 1938;.
Volker, J. F.; Hodge, H. C.; Wilson, H. J., and Van Voorhis, S. N.:  The Adsorption of Fluorides by Enamel, Dentin, Bone and Hydroxyapatite as Shown by the Radioactive Isotope , J. Biol. Chem. 134:543-548 ( (July) ) 1940;.
Perry, Mabel W., and Armstrong, W. D.:  On the Manner of Acquisition of Fluorine by Mature Teeth , J. Nutrition 21:35-44 ( (Jan.) ) 1941;.
Norvold, R. W.; Inglis, J. H., and Armstrong, W. D.:  External Acquisition of Fluorine by Enamel , J. Dent. Res. 20:232-233 ( (June) ) 1941;, Proc.
McClure, F. J.:  Fluorine Acquired by Mature Dog's Teeth , Science 95:256 ( (March 6) ) 1942;.
Volker, J. F.:  Effect of Fluorine on Solubility of Enamel and Dentin , Proc. Soc. Exper. Biol. & Med. 42:725-727 ( (Dec.) ) 1939;
 Solubility of Fluorosed Enamel and Dentin , VolkerProc. Soc. Exper. Biol. & Med. 43:643-645 ( (April) ) 1940;.
Arnold, F. A., Jr., and McClure, F. J.:  Observations on Induced Dental Caries in Rats: II. The Effect of Subcutaneous Injection of Fluoride , J. Dent. Res. 20:457-463 ( (Oct) ) 1941;.
Cheyne, V. D.: J. Am. Dent. A. 29:804-807 ( (May) ) 1942;.
Sharpless, G. R., and McCollum, E. V.:  Is Fluorine an Indispensable Element in the Diet? J. Nutrition 6:163-178 ( (March) ) 1933;.
Evans, R. J., and Phillips, P. H.:  A New Low Fluorine Diet and Its Effect on the Rat , J. Nutrition 18:353-360 ( (Oct.) ) 1939;.
Robinson, W. O.:  Determination of Selenium in Wheat and Soils , J. A. Off. Agr. Chem. 16:423-424, 1933;.
Franke, K. W.:  A New Toxicant Occurring Naturally in Certain Samples of Plant Foodstuffs. I. Results Obtained in Preliminary Feeding Trials , J. Nutrition 8:597-608 ( (Nov.) ) 1934;.
Moxon, A. L.: Alkali Disease or Selenium Poisoning , Bull. 311. South Dakota Agr. Exper. Sta., (May) 1937;. pp. 1-91.
Franke, K. W., and Painter, E. P.:  Selenium in Proteins from Toxic Foodstuffs: 1. Remarks on the Occurrence and Nature of the Selenium Present in a Number of Foodstuffs or Their Derived Products , Cereal Chem. 13:67-70 ( (Jan.) ) 1936;.
Jones, D. B.; Horn, M. J., and Gersdorff, C. E. F.:  The Selenium and Cystine Contents of Some Partial Hydrolysis Products of Gluten from Toxic Wheat , Cereal Chem. 14:130-134 ( (Jan.) ) 1937;.
Trealease, S. F.:  Bad Earth , Scient. Month. 54:13-28 ( (Jan.) ) 1942;.
Moxon.174 Smith, Lillie, Stohlman and Westfall.179
Franke, K. W., and Tully, W. C.:  A New Toxicant Occurring Naturally in Certain Samples of Plant Foodstuffs: V. Low Hatchability Due to Deformities in Chicks , Poultry Sc. 14:273-279, 1935;.
Franke, K. W.; Moxon, A. L.; Foley, W. E., and Tully, W. C.:  Monstrosities Produced by the Injection of Selenium Salts into Hen's Eggs , Anat. Rec. 65:15-22 ( (April) ) 1936;.
Smith, M. I.; Lillie, R. D.; Stohlman, E. F., and Westfall, B. B.: Studies in Chronic Selenosis , Bull., 174, Nat. Inst. Health, 1940;.
Smith, M. I.:  The Influence of Diet on the Chronic Toxicity of Selenium , Pub. Health Rep. 54:1441-1453 ( (Aug. 4) ) 1939;
Lewis, H. B.; Schultz, J., and Gortner, R. A., Jr.:  Dietary Protein and the Toxicity of Sodium Selenite in the White Rat , J. Pharmacol. & Exper. Therap. 68:292-299 ( (Feb.) ) 1940;.
Wright, C. I.:  The Effect of Sodium Selenite and Selenate on the Oxygen Consumption of Mammalian Tissues , Pub. Health Rep. 53:1825-1836 ( (Oct. 14) ) 1938;
 Effect of Selenium on Urease and Arginase , J. Pharmacol. & Exper. Therap. 68:220-230 ( (Feb.) ) 1940;.
Smith, M. T.; Franke, K. W., and Westfall, B. B.:  Selenium Problem in Relation to Public Health: Preliminary Survey to Determine Possibility of Selenium Intoxication in the Rural Population Living on Seleniferous Soil , Pub. Health Rep. 51:1496-1505 ( (Oct. 30) ) 1936;.
Smith, M. I., and Westfall, B. B.:  Further Field Studies on the Selenium Problem in Relation to Public Health , Pub. Health Rep. 52:1375-1384 ( (Oct. 1) ) 1937;.
Sterner, J. H., and Lidfeldt, Viola:  The Selenium Content of "Normal" Urine , J. Pharmacol. & Exper. Therap. 73:205-211 ( (Oct.) ) 1941;.
Smith, M. I.:  Chronic Endemic Selenium Poisoning , J. A. M. A. 116:562-567 [ (Feb. 15) ] 1941;
Dudley, H. C.:  Selenium as a Potential Industrial Hazard , Pub. Health Rep. 53:281-292 [ (Feb. 25) ] 1938;
Bertrand, G., and Aqulhon, H.:  Sur la présence normale du bore chez les animaux , Compt. rend. Acad. d. sc. 155:248-251, 1912;.
Yue, Pao Sen: The Biological Distribution of Boron, dissertation, Johns Hopkins University, May 1937.
Hove, E.; Elvehjem, C. A., and Hart, E. B.:  Boron in Animal Nutrition , Am. J. Physiol. 127:689-701 ( (Nov.) ) 1939;.
Wright and Papisch.9 Blumberg and Rask.9 Drea: Spectrum Analysis for Trace Elements in the Ashes of Human, Goat and Cow Milk.9
Drea, W. F.:  Spectrum Analysis of Hen Eggs and Chick Tissues , J. Nutrition 10:351-355 ( (Oct.) ) 1935;.
Kent, N. L., and McCance, R. A.:  The Absorption and Excretion of "Minor" Elements by Man: 1. Silver, Gold, Lithium, Boron and Vanadium , Biochem. J. 35:837-844 ( (July) ) 1941;.
Orent-Keiles, E.:  The Role of Boron in the Diet of the Rat , Proc. Soc. Exper. Biol. & Med. 44:199-202 ( (May) ) 1940;.
McCollum, E. V.; Rask, O. S., and Becker, J. E.:  A Study of the Possible Role of Aluminum Compounds in Animal and Plant Physiology , J. Biol. Chem. 77:753-768, 1928;.
Myers, V. C., and Mull, J. W.:  The Influence of the Administration of Aluminum on the Aluminum Content of the Tissues and on the Growth and Reproduction of Rats , J. Biol. Chem. 78:605-613, 1928;.
Mackenzie, K.:  Excretion and Absorption of Aluminum in the Pig , Biochem. J. 24:1433-1441, 1930;
 Excretion and Absorption of Aluminum in the Rat , MackenzieBiochem. J. 25:287-291, 1931;.
Wührer, J.:  Zur Frage der Resorption von Aluminium im Organismus, mit Berücksichtigung des normalen Aluminiumgehalts tierischer Gewebe , Biochem. Ztschr. 265:169-180, 1933;.
Burn, J. H.: Aluminium and Foods , Res. Rep. Ext. Ser. 162 Brit. Non-Ferrous Metals Res. Assn., (April) 1932;, p. 1-29.
Beal, G. D.: Unangst, R. B.; Wigman, H. B., and Cox, G. J.:  Aluminum Content of Foodstuffs Cooked in Aluminum and in Glass , Indust. & Engin. Chem. 24:405-407 ( (April) ) 1932;.
Monier-Williams, G. W.: Aluminum in Food , Reports on Public Health and Medical Subjects 78, London, Ministry of Health, 1935;.
Hove, E.; Elvehjem, C. A., and Hart, E. B.:  Aluminum in the Nutrition of the Rat , Am. J. Physiol. 123:640-643 ( (Sept.) ) 1938;.
Scoular, Florence I.:  A Quantitative Study by Means of Spectrographic Analysis of Aluminum in Nutrition , J. Nutrition 17:393-405 ( (April) ) 1939;.
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To understand the clinical management of acute heart failure syndromes.
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