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ARTICLE |

THE INCUBATION PERIOD IN EPIDEMIC POLIOMYELITIS FREE

ALBERT E. CASEY, M.D.
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This work was supported by the National Foundation for Infantile Paralysis and the Alabama and Walker County departments of public health.


JAMA. 1942;120(11):805-807. doi:10.1001/jama.1942.02830460003002
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Recent reviews of work on poliomyelitis1 contain no data pertinent to the incubation period of this disease in man. Many persons following Wickmann's2 lead attempted to estimate the incubation period from the occurrence of multiple cases in given families. Aycock and Eaton,3 in studies of multiple cases in more than 500 families, demonstrated that simultaneous infection is the rule in familial poliomyelitis and that the shorter intervals are probably due to a variation in the incubation period in simultaneously infected persons. Since the method of transmission of the disease has not been proved for man,4 the only feasible method of estimating the incubation period directly is to collect a series of instances in which the initial victim in a neighborhood either visited or was visited by a patient with acute poliomyelitis from some other neighborhood.

In an extensive outbreak in Walker County, Ala., in the summer

REFERENCES

Survey by the International Committee for the Study of Infantile Paralysis , Organized by Jeremiah Milbank, Baltimore, Williams & Wilkins Company, 1932;, p. 370.
Wickmann, O. I.: Beitrage zur Kenntniss der Heine-Medinschen Krankheit , Berlin, Verlag Karger, 1907;.
Aycock, W. L., and Eaton, P.:  The Epidemiology of Infantile Paralysis: The Relation Between Multiple Cases in the Same Family , Am. J. Hyg. 5: 724-732, 1925;.
Clark, P. F.; Armstrong, C.; Rivers, T. M.; Goodpasture, E. W.; Paul, J. R., and Ober, F. R.: Infantile Paralysis: A Symposium Delivered at Vanderbilt University , National Foundation for Infantile Paralysis, Inc., New York, 1941;.
Casey, A. E.:  Observations on an Epidemic of Poliomyelitis , Science 95:359-360 ( (April 3) ) 1942;.
The minimum incubation period of three days, as previously published,5 was in error and was the interval between the onset of the prodromal period in the 2 cases rather than the period from exposure to onset of prodromal symptoms of the victim.
Lennon, G. T.:  A Report of the Infantile Paralysis Epidemic in Haverhill , Boston M. & S. J. 197:916-920 ( (Nov. 17) ) 1927;.
Crouch, J. H.:  Epidemiological Aspects of the Recent Poliomyelitis Outbreak in Fort Worth, Texas , Texas State J. Med. 23:414-416 ( (Oct.) ) 1927;.
Aycock, W. L., and Luther, E. H.:  The Incubation Period in Poliomyelitis , J. Prev. Med. 3: 103-120 ( (March) ) 1929;.
Perkins, J. E.:  Apparent Spread of Poliomyelitis Through Four Families , Minnesota Med. 24:924-935 ( (Nov.) ) 1941;.
Aycock and Eaton (footnotes 3 and 9).
Aycock, W. L., and Eaton, P.:  A Comparison Between Multiple Cases of Measles, Scarlet Fever and Infantile Paralysis , Am. J. Hyg. 5:733-741 ( (Nov.) ) 1925;.
Howe, H. A., and Bodian, David: Neural Mechanisms in Poliomyelitis , The Commonwealth Fund, New York, Oxford University Press, 1942;.
Faber, H. K., and Silverberg, R. J.:  Experimental Air-Borne Infection with Poliomyelitis Virus , Science 94: 566-568 ( (Dec. 12) ) 1941;.

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Survey by the International Committee for the Study of Infantile Paralysis , Organized by Jeremiah Milbank, Baltimore, Williams & Wilkins Company, 1932;, p. 370.
Wickmann, O. I.: Beitrage zur Kenntniss der Heine-Medinschen Krankheit , Berlin, Verlag Karger, 1907;.
Aycock, W. L., and Eaton, P.:  The Epidemiology of Infantile Paralysis: The Relation Between Multiple Cases in the Same Family , Am. J. Hyg. 5: 724-732, 1925;.
Clark, P. F.; Armstrong, C.; Rivers, T. M.; Goodpasture, E. W.; Paul, J. R., and Ober, F. R.: Infantile Paralysis: A Symposium Delivered at Vanderbilt University , National Foundation for Infantile Paralysis, Inc., New York, 1941;.
Casey, A. E.:  Observations on an Epidemic of Poliomyelitis , Science 95:359-360 ( (April 3) ) 1942;.
The minimum incubation period of three days, as previously published,5 was in error and was the interval between the onset of the prodromal period in the 2 cases rather than the period from exposure to onset of prodromal symptoms of the victim.
Lennon, G. T.:  A Report of the Infantile Paralysis Epidemic in Haverhill , Boston M. & S. J. 197:916-920 ( (Nov. 17) ) 1927;.
Crouch, J. H.:  Epidemiological Aspects of the Recent Poliomyelitis Outbreak in Fort Worth, Texas , Texas State J. Med. 23:414-416 ( (Oct.) ) 1927;.
Aycock, W. L., and Luther, E. H.:  The Incubation Period in Poliomyelitis , J. Prev. Med. 3: 103-120 ( (March) ) 1929;.
Perkins, J. E.:  Apparent Spread of Poliomyelitis Through Four Families , Minnesota Med. 24:924-935 ( (Nov.) ) 1941;.
Aycock and Eaton (footnotes 3 and 9).
Aycock, W. L., and Eaton, P.:  A Comparison Between Multiple Cases of Measles, Scarlet Fever and Infantile Paralysis , Am. J. Hyg. 5:733-741 ( (Nov.) ) 1925;.
Howe, H. A., and Bodian, David: Neural Mechanisms in Poliomyelitis , The Commonwealth Fund, New York, Oxford University Press, 1942;.
Faber, H. K., and Silverberg, R. J.:  Experimental Air-Borne Infection with Poliomyelitis Virus , Science 94: 566-568 ( (Dec. 12) ) 1941;.
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