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PARENTERALLY ADMINISTERED NITROGEN FREE

JAMA. 1941;116(9):838-839. doi:10.1001/jama.1941.02820090038011
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Although the intravenous administration of nutrient dextrose is a method regularly employed in the clinic, this procedure furnishes no other nutritional elements except water. The requirement for electrolyte may be also readily fulfilled by the use of saline solution, and some efforts have been made to meet the nutritional and metabolic needs for fat by the intravenous administration of fine emulsions of fat.1 The problem of protein requirement is more difficult; moreover, the importance of protein in the diet frequently becomes accentuated in instances in which oral intake of this foodstuff becomes difficult or impossible. Several approaches are available for parenteral administration of protein and some of these have yielded encouraging results. It has been possible2 to maintain nitrogen equilibrium by the intravenous administration of plasma. However, the quantity of plasma required daily in order to meet the minimum protein requirements is relatively large. Furthermore, unhydrolyzed proteins, in

REFERENCES

Holt, L. E., Jr.; Tidwell, H. C., and Scott, T. F. M.:  The Intravenous Administration of Fat: A Practical Therapeutic Procedure , J. Pediat. 6:151 ( (Feb.) ) 1935;.
Holman, R. L.; Mahoney, E. B., and Whipple, G. H.:  Blood Plasma Protein Given by Vein, Utilized in Body Metabolism , J. Exper. Med. 59:269 ( (March) ) 1934;.
Rose, W. C.: Physiol. Rev. 18:109 ( (Jan.) ) 1938;.
Rose, W. C., and Rice, E. E.: Science 90:186 ( (Aug. 25) ) 1939;.
Burroughs, E. W.; Burroughs, H. S., and Mitchell, H. H.: J. Nutrition 19:363 ( (April) ) 1940;.
Elman, Robert, and Weiner, D. O.:  Intravenous Alimentation , J. A. M. A. 112:796 ( (March 4) ) 1939;.
Shohl, A. T.; Butler, A. M.; Blackfan, K. D., and Mac-Lachlan, E.: J. Pediat. 15:469 ( (Oct.) ) 1939;.
Farr, L. E., and MacFayden, D. A.: Proc. Soc. Exper. Biol. & Med. 42:444 ( (Nov.) ) 1939;.
Altshuler, S. S.; Hensel, H. M., and Sahyun, M.: Am. J. M. Sc. 200:239 ( (Aug.) ) 1940;.

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Holt, L. E., Jr.; Tidwell, H. C., and Scott, T. F. M.:  The Intravenous Administration of Fat: A Practical Therapeutic Procedure , J. Pediat. 6:151 ( (Feb.) ) 1935;.
Holman, R. L.; Mahoney, E. B., and Whipple, G. H.:  Blood Plasma Protein Given by Vein, Utilized in Body Metabolism , J. Exper. Med. 59:269 ( (March) ) 1934;.
Rose, W. C.: Physiol. Rev. 18:109 ( (Jan.) ) 1938;.
Rose, W. C., and Rice, E. E.: Science 90:186 ( (Aug. 25) ) 1939;.
Burroughs, E. W.; Burroughs, H. S., and Mitchell, H. H.: J. Nutrition 19:363 ( (April) ) 1940;.
Elman, Robert, and Weiner, D. O.:  Intravenous Alimentation , J. A. M. A. 112:796 ( (March 4) ) 1939;.
Shohl, A. T.; Butler, A. M.; Blackfan, K. D., and Mac-Lachlan, E.: J. Pediat. 15:469 ( (Oct.) ) 1939;.
Farr, L. E., and MacFayden, D. A.: Proc. Soc. Exper. Biol. & Med. 42:444 ( (Nov.) ) 1939;.
Altshuler, S. S.; Hensel, H. M., and Sahyun, M.: Am. J. M. Sc. 200:239 ( (Aug.) ) 1940;.
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To understand the clinical management of acute heart failure syndromes.
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