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ARTICLE |

THERAPEUTICS OF TESTICULAR DYSFUNCTION FREE

JAMES B. HAMILTON
[+] Author Affiliations

The following members of the group engaged in study of problems pertaining to androgenic substances gave aid and opinions which were responsible for some of the data presented: Drs. Gilbert Hubert, Judson Gilbert, Edgar Allen, Edward Edwards, Ralph Dorfman and Hubert Catchpole.


JAMA. 1941;116(17):1903-1908. doi:10.1001/jama.1941.62820170003009
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The first major advancements in endocrinologic knowledge came from studies pertaining to the testis. Aristotle1 recognized that the absence of the testis is responsible for the changes observed in castrate animals and man. In 1849 Berthold2 concluded that the testis produces an internal secretion, since capons with an implanted testis have comb growth and other characteristics of the cock. Thereafter, the study of testicular function lagged behind that of other ductless glands until, as a result of intensive study3 during the last decade, the status of androgenic substances shifted abruptly from that of relatively unknown materials to that of highly active crystalline compounds that can be prepared synthetically and are available for therapeutic use.

The androgens of chief interest in therapeusis are testosterone, a substance isolated from testis tissue (of the bull4), and androsterone and dehydroisoandrosterone, which are excreted in human urine.5 Clinically, testosterone is

REFERENCES

Aristotle:  Historia Animalium , translated by D'Arcy Thompson in Works of Aristotle , translated into English under the editorship of J. A. Smith and W. D. Ross, London, Oxford University Press, 1910;, vol. 4.
Berthold, A. A.: Transplantation der Hoden, Arch. f. Anat., Physiol. u. wissensch. Med., 1849, pp. 43-46.
McGee, L. C.; Juhn, M., and Domm, L. V.:  The Development of Secondary Sex Characters in Capons by Injections of Extracts of Bull Testes , Am. J. Physiol. 87:406-435 ( (Dec.) ) 1928;.
Butenandt, A., and Hanisch, G.:  Ueber Testosteron: Umwandlung des Dehydroandrosterons in Androstendiol und Testosteron; ein Weg zur Darstellung des Testosterons aus Cholesterin , Ztschr. f. physiol. Chem. 237:89-97, 1935;.
Ruzicka, L., and Wettstein, A.:  Ueber die künstliche Herstellung des Testikelhormons, Testosteron (Androsten-3-on-17-ol) , Helvet. chim. acta 18:1264-1275, 1935;.
David, K.; Dingemanse, E.; Freud, J., and Laquer, Ernst:  Ueber krystallinisches männliches Hormon aus Hoden (Testosteron) wirksamer als aus Harn oder aus Cholesterin bereitetes Androsteron , Ztschr. f. physiol. Chem. 233:281-282, 1935;.
Butenandt, A., and Tscherning, K.:  Ueber Androsteron, ein krystallisiertes männliches Sexualhormon , Ztschr. f. physiol. Chem. 229:167-184, 1934;.
Moore, C. R.:  Biology of the Testes , in Allen, E.; Danforth, C. H., and Doisy, E. A.: Sex and Internal Secretions , Baltimore, Williams and Wilkins Company, 1939;, chap. 1.
In eunuchoidism, a eunuch-like state, the testes are present but do not secrete properly; the range of patients is from those like castrates to those more like normal men.
Hamilton, J. B., and Hubert, G.:  Vocal Changes in Eunuchoidal and Castrated Men upon Administration of Male Hormone Substance , Am. J. Physiol. 129:372-373 ( (May) ) 1940;.
Gallagher, T. F.; Peterson, D. H.; Dorfman, R. I.; Kenyon, A. T., and Koch, F. C.:  The Daily Urinary Excretion of Estrogenic and Androgenic Substances by Normal Men and Women , J. Clin. Investigation 16:695-703 ( (Sept.) ) 1937;.
Kenyon, A. T.; Gallagher, T. F.; Peterson, D. H.; Dorfman, R. I., and Koch, F. C.:  The Urinary Excretion of Androgenic and Estrogenic Substances in Certain Endocrine States: Studies in Hypogonadism, Gynecomastia and Virilism , J. Clin. Investigation 16:705-717 ( (Sept.) ) 1937;.
Hamilton, J. B., and Hubert G.:  Photographic Nature of Tanning of the Human Skin as Shown by Studies of Male Hormone Therapy , Science 88:481 ( (Nov. 18) ) 1938;.
Edwards, E.; Hamilton, J. B.; Duntley, S. Q., and Hubert, G.:  Cutaneous Vascular and Pigmentary Changes in Castrate and Eunuchoid Men , Endocrinology 28:119-128 ( (Jan.) ) 1941;.
Hamilton, J. B., and Hubert, G.:  Male Hormone Substance, Inductor of Acne , Anat. Rec. 76 ( (supp. 2) ):28-29 (Feb. 24) 1940;.
Hamilton, J. B., and Hubert, G.:  Differential Diagnosis of Pseudocryptorchidism and True Cryptorchidism , Endocrinology 21:644-648 ( (Sept.) ) 1937;.
Carmichael, H. T., and Kenyon, A. T.:  Eunuchoidism: A Psychiatric and Endocrine Study of Six Cases , Arch. Neurol. & Psychiat. 40:717-742 ( (Oct.) ) 1938;.
Howard, J. E., and Vest, S. A.:  II. Further Observations on Testosterone Propionate in Adult Hypogonadism, and Preliminary Report on the Implantation of Testosterone , Am. J. M. Sc. 198:823-837 ( (Dec.) ) 1939;.
McCullagh, E. P., and McGurl, F. J.:  The Effects of Testosterone Propionate on Epiphyseal Closure, Sodium and Chloride Balance and on Sperm Counts , Endocrinology 26:377-384 ( (March) ) 1940;.
Hamilton, J. B.:  Treatment of Sexual Underdevelopment with Synthetic Male Hormone Substance , Endocrinology 21:649-654 ( (Sept.) ) 1937;.
Eidelsberg, J., and Ornstein, E. A.:  Observations on the Continued Use of Male Sex Hormone Over Long Periods of Time , Endocrinology 26:46-53 ( (Jan.) ) 1940;.
Kenyon, A. T.:  The Effect of Testosterone Propionate on the Genitalia, Prostate, Secondary Sex Characters, and Body Weight in Eunuchoidism , Endocrinology 23:121-134 ( (Aug.) ) 1938;.
Deanesly, R., and Parkes, A. S.:  Factors Influencing the Effectiveness of Administered Hormone , Proc. Roy Soc., London, s. B 124:279-298 ( (Dec. 7) ) 1937;.
Hamilton, J. B., and Dorfman, R. I.:  Influence of the Vehicle upon the Length and Strength of the Action of Male Hormone Substance, Testosterone Propionate , Endocrinology 24:711-719 ( (May) ) 1939;.
Vest, S. A., and Howard, J. E.:  Clinical Experiments with Androgens: IV. A Method of Implantation of Crystalline Testosterone , J. A. M. A. 113:1869-1872 ( (Nov. 18) ) 1939;.
Dorfman, R. I., and Hamilton, J. B.:  Urinary Excretion of Androgenic Substances After Intramuscular and Oral Administration of Testosterone Propionate to Humans , J. Clin. Investigation 18:67-71 ( (Jan.) ) 1939;.
Callow, N. H.:  The Isolation of Two Transformation Products of Testosterone from Urine , Biochem. J. 33:559-564 ( (April) ) 1939;.
Dorfman, R. I.; Cook, J. W., and Hamilton, J. B.:  Conversion by the Human of the Testis Hormone, Testosterone, into the Urinary Androgen, Androsterone , J. Biol. Chem. 130:285-295 ( (Sept.) ) 1939;.
Biskind, G. R., and Mark, J.:  The Inactivation of Testosterone Propionate and Estrone in Rats , Bull. Johns Hopkins Hosp. 65:212-217 ( (Aug.) ) 1939;.
Pfeiffer, C. A.:  Sexual Differences of the Hypophyses and Their Determination by the Gonads , Am. J. Anat. 58:195-225 ( (Jan.) ) 1936;.
Dorfman, R. I., and Hamilton, J. B.:  Concerning the Metabolism of Testosterone to Androsterone , J. Biol. Chem. 133:753-760 ( (May) ) 1940;.
Foss, G. L.:  Effect of Testosterone Propionate on a Post-Puberal Eunuch , Lancet 2:1307-1309 ( (Dec. 4) ) 1937;.
Callow.23a Dorfman and others.23b Dorfman and Hamilton.25
Kenyon, A. T.; Sandiford, I.; Bryan, A. H.; Knowlton, K., and Koch, F. C.:  The Effect of Testosterone Propionate on Nitrogen, Electrolyte, Water and Energy Metabolism in Eunuchoidism , Endocrinology 23:135-153 ( (Aug.) ) 1938;.
Moore, C. R., and Gallagher, T. F.:  Seminal-Vesicle and Prostate Function as a Testis-Hormone Indicator: The Electric Ejaculation Test , Am. J. Anat. 45:39-69 ( (Jan.) ) 1930;.
Jeffries, M. E.:  Hormone Production by Experimental Cryptorchid Rat Testes as Indicated by the Seminal-Vesicle and Prostate-Cytology Tests , Anat. Rec. 48:131-139 ( (Jan. 25) ) 1931;.
Nelson, W. O.: Some Factors Involved in the Control of the Gametogenic and Endocrine Functions of the Testis, Cold Spring Harbor Symposia on Quantitative Biology , Cold Spring Harbor, L. I., New York, The Biological Laboratory 1937;, vol. 5, pp. 123-135.
Fukui, N.:  On the Action of Heat Rays upon the Testicle: An Historical, Hygienic and Endocrinological Study , Acta scholae med. univ. imp. in Kioto 6:225-258, 1923;
Moore, C. R.:  Properties of the Gonads as Controllers of Somatic and Psychical Characteristics: VIII. Heat Application and Testicular Degeneration; the Function of the Scrotum , Am. J. Anat. 34:337-357 ( (Nov.) ) 1924;.
Gilbert, J. B., and Hamilton, J. B.:  Incidence and Nature of Tumors in Ectopic Testes , Surg., Gynec. & Obst. 71:731-743 ( (Dec.) ) 1940;.
Shapiro, B.:  Klinische Studien über die Wirkung des Hypophysenvorderlappens auf den männlichen Genitalapparat , Ztschr. f. klin. Med. 114:610-622, 1930;.
Engle, E. T.:  Experimentally Induced Descent of the Testis in the Macacus Rhesus Monkey by Hormones from the Anterior Pituitary and Pregnancy Urine , Endocrinology 16:513-520 ( (Sept.) -Oct.) 1932;.
Thompson, W. O., and Heckel, N. J.:  Undescended Testes: Present Status of Glandular Treatment , J. A. M. A. 112:397-403 ( (Feb. 4) ) 1939;.
Hamilton, J. B., and Hubert, G.:  Effect of Synthetic Male Hormone Substance on Descent of Testicles in Human Cryptorchidism , Proc. Soc. Exper. Biol. & Med. 39:4-5 ( (Oct.) ) 1938;.
Hotchkiss, R. S.; Brunner, E. K., and Grenley, P.:  Semen Analyses of Two Hundred Fertile Men , Am. J. M. Sc. 196:362-384 ( (Sept.) ) 1938;.
Moench, G. L.:  The Relation of Certain Seminal Findings to Fertility, with Special Reference to Sperm Concentration and the Significance of Testicular Epithelial Cells in Semen , Am. J. Surg. 47:586-596 ( (March) ) 1940;.
Smith, P. E.:  Comparative Effects of Hypophysectomy and Therapy on the Testes of Monkeys and Rats , in Brouha, L.: Les hormones sexuelles , Paris, J. Hermann, 1938;, pt. (3) , pp. 201-208.
Huberman, J.; Israeloff, H. H., and Hymowitz, B.:  Effects on Spermatogenesis of a Follicle-Stimulating Extract Obtained from Menopausal or Castrate Urines , Endocrinology 21:67-71 ( (Jan.) ) 1937;.
Heckel, N. J.:  The Gonadotropic and the Gonadotropic-like Factor in the Treatment of Male Sterility , Endocrinology 22:111-114 ( (Jan.) ) 1938;.
Rubinstein, H. S.:  The Induction of Sexual Maturity in the Genitally Hypoplastic Adult Through the Use of Testosterone Propionate , J. A. M. A. 111:1818-1821 ( (Nov. 12) ) 1938;.
Rubinstein, H. S., and Kurland, A. A.:  Effect of Testosterone Propionate on Spermatogenesis in Human , South. M. J. 32:499-503 ( (May) ) 1939;.
Heckel, N. J.:  The Influence of Testosterone-Propionate upon Benign Hypertrophy and Spermatogenesis: A Clinical and Pathological Study in the Human , J. Urol. 43:268-308 ( (Feb.) ) 1940;.
Ferguson, R. S.:  Quantitative Behavior of Prolan A in Teratoma Testis , Am. J. Cancer 18:269-295 ( (June) ) 1933;.
Hamilton, J. B., and Gilbert, J.:  New Conception of Etiological Factors in the Production of Symptoms Observed in Benign Prostatic Hypertrophy: Mechanism of Control by Male Hormone Substance , Tr. West. Branch Soc., Am. Urol. A. 7: 144-145, 1938;.
Hesser, F. H.; Langworthy, O. R., and Vest, S. A.:  Muscle Strength in Myotonia Atrophica (Dystrophia Myotonica) Improved by Testosterone Propionate , Endocrinology 26:241-243 ( (Feb.) ) 1940;.
Hamilton, J. B., and Wolfe, J. M.:  The Effect of Synthetic Androgen upon the Gonadotropic Potency of the Anterior Pituitary , Endocrinology 22:360-365 ( (March) ) 1938;.
Greene, R. R., and Ivy, A. C.:  The Experimental Production of Intersexuality in the Female Rat with Testosterone , Science 86:200-201 ( (Aug. 27) ) 1937;
Dantchakoff, V.:  Sur la faculté des tissus induits par l'hormone mâle, d'édifier de nouvelles structures chez l'embryon de cobaye femelle , Compt. rend. Soc. de biol. 124:516-518, 1937;.

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Aristotle:  Historia Animalium , translated by D'Arcy Thompson in Works of Aristotle , translated into English under the editorship of J. A. Smith and W. D. Ross, London, Oxford University Press, 1910;, vol. 4.
Berthold, A. A.: Transplantation der Hoden, Arch. f. Anat., Physiol. u. wissensch. Med., 1849, pp. 43-46.
McGee, L. C.; Juhn, M., and Domm, L. V.:  The Development of Secondary Sex Characters in Capons by Injections of Extracts of Bull Testes , Am. J. Physiol. 87:406-435 ( (Dec.) ) 1928;.
Butenandt, A., and Hanisch, G.:  Ueber Testosteron: Umwandlung des Dehydroandrosterons in Androstendiol und Testosteron; ein Weg zur Darstellung des Testosterons aus Cholesterin , Ztschr. f. physiol. Chem. 237:89-97, 1935;.
Ruzicka, L., and Wettstein, A.:  Ueber die künstliche Herstellung des Testikelhormons, Testosteron (Androsten-3-on-17-ol) , Helvet. chim. acta 18:1264-1275, 1935;.
David, K.; Dingemanse, E.; Freud, J., and Laquer, Ernst:  Ueber krystallinisches männliches Hormon aus Hoden (Testosteron) wirksamer als aus Harn oder aus Cholesterin bereitetes Androsteron , Ztschr. f. physiol. Chem. 233:281-282, 1935;.
Butenandt, A., and Tscherning, K.:  Ueber Androsteron, ein krystallisiertes männliches Sexualhormon , Ztschr. f. physiol. Chem. 229:167-184, 1934;.
Moore, C. R.:  Biology of the Testes , in Allen, E.; Danforth, C. H., and Doisy, E. A.: Sex and Internal Secretions , Baltimore, Williams and Wilkins Company, 1939;, chap. 1.
In eunuchoidism, a eunuch-like state, the testes are present but do not secrete properly; the range of patients is from those like castrates to those more like normal men.
Hamilton, J. B., and Hubert, G.:  Vocal Changes in Eunuchoidal and Castrated Men upon Administration of Male Hormone Substance , Am. J. Physiol. 129:372-373 ( (May) ) 1940;.
Gallagher, T. F.; Peterson, D. H.; Dorfman, R. I.; Kenyon, A. T., and Koch, F. C.:  The Daily Urinary Excretion of Estrogenic and Androgenic Substances by Normal Men and Women , J. Clin. Investigation 16:695-703 ( (Sept.) ) 1937;.
Kenyon, A. T.; Gallagher, T. F.; Peterson, D. H.; Dorfman, R. I., and Koch, F. C.:  The Urinary Excretion of Androgenic and Estrogenic Substances in Certain Endocrine States: Studies in Hypogonadism, Gynecomastia and Virilism , J. Clin. Investigation 16:705-717 ( (Sept.) ) 1937;.
Hamilton, J. B., and Hubert G.:  Photographic Nature of Tanning of the Human Skin as Shown by Studies of Male Hormone Therapy , Science 88:481 ( (Nov. 18) ) 1938;.
Edwards, E.; Hamilton, J. B.; Duntley, S. Q., and Hubert, G.:  Cutaneous Vascular and Pigmentary Changes in Castrate and Eunuchoid Men , Endocrinology 28:119-128 ( (Jan.) ) 1941;.
Hamilton, J. B., and Hubert, G.:  Male Hormone Substance, Inductor of Acne , Anat. Rec. 76 ( (supp. 2) ):28-29 (Feb. 24) 1940;.
Hamilton, J. B., and Hubert, G.:  Differential Diagnosis of Pseudocryptorchidism and True Cryptorchidism , Endocrinology 21:644-648 ( (Sept.) ) 1937;.
Carmichael, H. T., and Kenyon, A. T.:  Eunuchoidism: A Psychiatric and Endocrine Study of Six Cases , Arch. Neurol. & Psychiat. 40:717-742 ( (Oct.) ) 1938;.
Howard, J. E., and Vest, S. A.:  II. Further Observations on Testosterone Propionate in Adult Hypogonadism, and Preliminary Report on the Implantation of Testosterone , Am. J. M. Sc. 198:823-837 ( (Dec.) ) 1939;.
McCullagh, E. P., and McGurl, F. J.:  The Effects of Testosterone Propionate on Epiphyseal Closure, Sodium and Chloride Balance and on Sperm Counts , Endocrinology 26:377-384 ( (March) ) 1940;.
Hamilton, J. B.:  Treatment of Sexual Underdevelopment with Synthetic Male Hormone Substance , Endocrinology 21:649-654 ( (Sept.) ) 1937;.
Eidelsberg, J., and Ornstein, E. A.:  Observations on the Continued Use of Male Sex Hormone Over Long Periods of Time , Endocrinology 26:46-53 ( (Jan.) ) 1940;.
Kenyon, A. T.:  The Effect of Testosterone Propionate on the Genitalia, Prostate, Secondary Sex Characters, and Body Weight in Eunuchoidism , Endocrinology 23:121-134 ( (Aug.) ) 1938;.
Deanesly, R., and Parkes, A. S.:  Factors Influencing the Effectiveness of Administered Hormone , Proc. Roy Soc., London, s. B 124:279-298 ( (Dec. 7) ) 1937;.
Hamilton, J. B., and Dorfman, R. I.:  Influence of the Vehicle upon the Length and Strength of the Action of Male Hormone Substance, Testosterone Propionate , Endocrinology 24:711-719 ( (May) ) 1939;.
Vest, S. A., and Howard, J. E.:  Clinical Experiments with Androgens: IV. A Method of Implantation of Crystalline Testosterone , J. A. M. A. 113:1869-1872 ( (Nov. 18) ) 1939;.
Dorfman, R. I., and Hamilton, J. B.:  Urinary Excretion of Androgenic Substances After Intramuscular and Oral Administration of Testosterone Propionate to Humans , J. Clin. Investigation 18:67-71 ( (Jan.) ) 1939;.
Callow, N. H.:  The Isolation of Two Transformation Products of Testosterone from Urine , Biochem. J. 33:559-564 ( (April) ) 1939;.
Dorfman, R. I.; Cook, J. W., and Hamilton, J. B.:  Conversion by the Human of the Testis Hormone, Testosterone, into the Urinary Androgen, Androsterone , J. Biol. Chem. 130:285-295 ( (Sept.) ) 1939;.
Biskind, G. R., and Mark, J.:  The Inactivation of Testosterone Propionate and Estrone in Rats , Bull. Johns Hopkins Hosp. 65:212-217 ( (Aug.) ) 1939;.
Pfeiffer, C. A.:  Sexual Differences of the Hypophyses and Their Determination by the Gonads , Am. J. Anat. 58:195-225 ( (Jan.) ) 1936;.
Dorfman, R. I., and Hamilton, J. B.:  Concerning the Metabolism of Testosterone to Androsterone , J. Biol. Chem. 133:753-760 ( (May) ) 1940;.
Foss, G. L.:  Effect of Testosterone Propionate on a Post-Puberal Eunuch , Lancet 2:1307-1309 ( (Dec. 4) ) 1937;.
Callow.23a Dorfman and others.23b Dorfman and Hamilton.25
Kenyon, A. T.; Sandiford, I.; Bryan, A. H.; Knowlton, K., and Koch, F. C.:  The Effect of Testosterone Propionate on Nitrogen, Electrolyte, Water and Energy Metabolism in Eunuchoidism , Endocrinology 23:135-153 ( (Aug.) ) 1938;.
Moore, C. R., and Gallagher, T. F.:  Seminal-Vesicle and Prostate Function as a Testis-Hormone Indicator: The Electric Ejaculation Test , Am. J. Anat. 45:39-69 ( (Jan.) ) 1930;.
Jeffries, M. E.:  Hormone Production by Experimental Cryptorchid Rat Testes as Indicated by the Seminal-Vesicle and Prostate-Cytology Tests , Anat. Rec. 48:131-139 ( (Jan. 25) ) 1931;.
Nelson, W. O.: Some Factors Involved in the Control of the Gametogenic and Endocrine Functions of the Testis, Cold Spring Harbor Symposia on Quantitative Biology , Cold Spring Harbor, L. I., New York, The Biological Laboratory 1937;, vol. 5, pp. 123-135.
Fukui, N.:  On the Action of Heat Rays upon the Testicle: An Historical, Hygienic and Endocrinological Study , Acta scholae med. univ. imp. in Kioto 6:225-258, 1923;
Moore, C. R.:  Properties of the Gonads as Controllers of Somatic and Psychical Characteristics: VIII. Heat Application and Testicular Degeneration; the Function of the Scrotum , Am. J. Anat. 34:337-357 ( (Nov.) ) 1924;.
Gilbert, J. B., and Hamilton, J. B.:  Incidence and Nature of Tumors in Ectopic Testes , Surg., Gynec. & Obst. 71:731-743 ( (Dec.) ) 1940;.
Shapiro, B.:  Klinische Studien über die Wirkung des Hypophysenvorderlappens auf den männlichen Genitalapparat , Ztschr. f. klin. Med. 114:610-622, 1930;.
Engle, E. T.:  Experimentally Induced Descent of the Testis in the Macacus Rhesus Monkey by Hormones from the Anterior Pituitary and Pregnancy Urine , Endocrinology 16:513-520 ( (Sept.) -Oct.) 1932;.
Thompson, W. O., and Heckel, N. J.:  Undescended Testes: Present Status of Glandular Treatment , J. A. M. A. 112:397-403 ( (Feb. 4) ) 1939;.
Hamilton, J. B., and Hubert, G.:  Effect of Synthetic Male Hormone Substance on Descent of Testicles in Human Cryptorchidism , Proc. Soc. Exper. Biol. & Med. 39:4-5 ( (Oct.) ) 1938;.
Hotchkiss, R. S.; Brunner, E. K., and Grenley, P.:  Semen Analyses of Two Hundred Fertile Men , Am. J. M. Sc. 196:362-384 ( (Sept.) ) 1938;.
Moench, G. L.:  The Relation of Certain Seminal Findings to Fertility, with Special Reference to Sperm Concentration and the Significance of Testicular Epithelial Cells in Semen , Am. J. Surg. 47:586-596 ( (March) ) 1940;.
Smith, P. E.:  Comparative Effects of Hypophysectomy and Therapy on the Testes of Monkeys and Rats , in Brouha, L.: Les hormones sexuelles , Paris, J. Hermann, 1938;, pt. (3) , pp. 201-208.
Huberman, J.; Israeloff, H. H., and Hymowitz, B.:  Effects on Spermatogenesis of a Follicle-Stimulating Extract Obtained from Menopausal or Castrate Urines , Endocrinology 21:67-71 ( (Jan.) ) 1937;.
Heckel, N. J.:  The Gonadotropic and the Gonadotropic-like Factor in the Treatment of Male Sterility , Endocrinology 22:111-114 ( (Jan.) ) 1938;.
Rubinstein, H. S.:  The Induction of Sexual Maturity in the Genitally Hypoplastic Adult Through the Use of Testosterone Propionate , J. A. M. A. 111:1818-1821 ( (Nov. 12) ) 1938;.
Rubinstein, H. S., and Kurland, A. A.:  Effect of Testosterone Propionate on Spermatogenesis in Human , South. M. J. 32:499-503 ( (May) ) 1939;.
Heckel, N. J.:  The Influence of Testosterone-Propionate upon Benign Hypertrophy and Spermatogenesis: A Clinical and Pathological Study in the Human , J. Urol. 43:268-308 ( (Feb.) ) 1940;.
Ferguson, R. S.:  Quantitative Behavior of Prolan A in Teratoma Testis , Am. J. Cancer 18:269-295 ( (June) ) 1933;.
Hamilton, J. B., and Gilbert, J.:  New Conception of Etiological Factors in the Production of Symptoms Observed in Benign Prostatic Hypertrophy: Mechanism of Control by Male Hormone Substance , Tr. West. Branch Soc., Am. Urol. A. 7: 144-145, 1938;.
Hesser, F. H.; Langworthy, O. R., and Vest, S. A.:  Muscle Strength in Myotonia Atrophica (Dystrophia Myotonica) Improved by Testosterone Propionate , Endocrinology 26:241-243 ( (Feb.) ) 1940;.
Hamilton, J. B., and Wolfe, J. M.:  The Effect of Synthetic Androgen upon the Gonadotropic Potency of the Anterior Pituitary , Endocrinology 22:360-365 ( (March) ) 1938;.
Greene, R. R., and Ivy, A. C.:  The Experimental Production of Intersexuality in the Female Rat with Testosterone , Science 86:200-201 ( (Aug. 27) ) 1937;
Dantchakoff, V.:  Sur la faculté des tissus induits par l'hormone mâle, d'édifier de nouvelles structures chez l'embryon de cobaye femelle , Compt. rend. Soc. de biol. 124:516-518, 1937;.
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