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THE RELIEF OF MENOPAUSE SYMPTOMS BY ESTROGENIC PREPARATIONS FREE

ELMER L. SEVRINGHAUS, M.D.
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Read before the Section on Pharmacology and Therapeutics at the Eighty-Fifth Annual Session of the American Medical Association, Cleveland, June 15, 1934.


JAMA. 1935;104(8):624-628. doi:10.1001/jama.1935.02760080020005
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Therapeutic use of ovarian preparations for relief of the symptoms accompanying the menopause has met with varying and unpredictable success until within the last few years. The production of estrogenic preparations in biologically assayed form was the occasion for substantial improvement in clinical management of these patients. In 1929 the first American report of dependable treatment of the menopause with such material was published.1 Corroborative reports have appeared by Bowman and Bender2 in the field of psychiatry, by Hamblen3 in gynecology and by Werner and Collier4 in internal medicine. Experience with several standardized ovarian preparations is now so widespread among clinicians that there can no longer be the doubt of the efficacy of treatment expressed by King5 in 1928. The usefulness of the estrogenic substance has been shown to extend not only to the commoner types of climacteric symptoms but also to the not infrequent

REFERENCES

Sevringhaus, E. L., and Evans, J. S.:  Clinical Observations on the Use of an Ovarian Hormone: Amniotin , Am. J. M. Sc. 178: 638 ( (Nov.) ) 1929;.
Bowman, K. M., and Bender, Lauretta:  The Treatment of Involution Melancholia with Ovarian Hormone , Am. J. Psychiat. 11:867 ( (March) ) 1932;.
Hamblen, E. C.:  Clinical Experience with Follicular and Anterior Pituitary Sex Hormones: A Study of the Results of Treatments in 120 Patients , Virginia M. Monthly 59:464 ( (Nov.) ) 1932;.
Werner, A. A., and Collier, W. D.:  The Effect of Theelin Injections on the Castrated Woman , J. A. M. A. 100: 633 ( (March 4) ) 1933;.
King, J. T., and Patterson, Ellen:  Observations on the Menopause: II. The Effects of Various Ovarian Preparations on Symptoms of the Menopause and on Basal Metabolism , J. A. M. A. 91:1423 ( (Nov. 10) ) 1928;.
Sevringhaus, Elmer:  The Use of Folliculin in Involutional States , Am. J. Obst. & Gynec. 25:361 ( (March) ) 1933;.
Sevringhaus, E. L.:  Differentiation of Thyrotoxicosis and the Menopausal Disturbances . Endocrinology 15:536 ( (Nov.) -Dec.) 1931;.
Squibb's amniotin has been used in aqueous solution hypodermically, in hardened gelatin vaginal suppositories, in oil solution orally, and in oil solution hypodermically. Parke, Davis & Co.'s theelin has been given in aqueous hypodermic solution and in vaginal suppositories, and theelol has been given in tablets and capsules orally, Progynon, produced in Germany by Kahlbaum and imported by the Schering Corporation, has been used only in the tablets orally. For much of this material I am indebted to Dr. J. F. Anderson of E. R. Squibb and Sons and to Dr. E. A. Sharp of Parke, Davis & Co. A preliminary supply of progynon was also furnished by the Schering Corporation.
Since this manuscript was prepared, I have learned that the American products will be markedly reduced in retail cost shortly. Purchase may therefore well be made on a basis of cost per unit and type of medication desired.

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Sevringhaus, E. L., and Evans, J. S.:  Clinical Observations on the Use of an Ovarian Hormone: Amniotin , Am. J. M. Sc. 178: 638 ( (Nov.) ) 1929;.
Bowman, K. M., and Bender, Lauretta:  The Treatment of Involution Melancholia with Ovarian Hormone , Am. J. Psychiat. 11:867 ( (March) ) 1932;.
Hamblen, E. C.:  Clinical Experience with Follicular and Anterior Pituitary Sex Hormones: A Study of the Results of Treatments in 120 Patients , Virginia M. Monthly 59:464 ( (Nov.) ) 1932;.
Werner, A. A., and Collier, W. D.:  The Effect of Theelin Injections on the Castrated Woman , J. A. M. A. 100: 633 ( (March 4) ) 1933;.
King, J. T., and Patterson, Ellen:  Observations on the Menopause: II. The Effects of Various Ovarian Preparations on Symptoms of the Menopause and on Basal Metabolism , J. A. M. A. 91:1423 ( (Nov. 10) ) 1928;.
Sevringhaus, Elmer:  The Use of Folliculin in Involutional States , Am. J. Obst. & Gynec. 25:361 ( (March) ) 1933;.
Sevringhaus, E. L.:  Differentiation of Thyrotoxicosis and the Menopausal Disturbances . Endocrinology 15:536 ( (Nov.) -Dec.) 1931;.
Squibb's amniotin has been used in aqueous solution hypodermically, in hardened gelatin vaginal suppositories, in oil solution orally, and in oil solution hypodermically. Parke, Davis & Co.'s theelin has been given in aqueous hypodermic solution and in vaginal suppositories, and theelol has been given in tablets and capsules orally, Progynon, produced in Germany by Kahlbaum and imported by the Schering Corporation, has been used only in the tablets orally. For much of this material I am indebted to Dr. J. F. Anderson of E. R. Squibb and Sons and to Dr. E. A. Sharp of Parke, Davis & Co. A preliminary supply of progynon was also furnished by the Schering Corporation.
Since this manuscript was prepared, I have learned that the American products will be markedly reduced in retail cost shortly. Purchase may therefore well be made on a basis of cost per unit and type of medication desired.
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