The Women's Health Initiative (WHI) trial of estrogen plus progestin
hormone therapy represents a major landmark in medical research. The study
demonstrates that alteration of a woman's basic hormonal physiology over decades
in the interest of long-term disease prevention is fraught with hazard.1 The WHI investigators terminated the trial after an
assessment of the overall risk-benefit ratio of this combined hormone therapy
regimen failed to demonstrate a benefit. A statistically significant 26% increase
in breast cancer incidence contributed to the overall negative effect of estrogen
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