Author Contributions: Drs Strangfeld, Listing, and Zink had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Strangfeld, Listing, Zink.
Acquisition of data: Strangfeld, Herzer, Liebhaber, Rockwitz, Richter.
Analysis and interpretation of data: Strangfeld, Listing, Zink.
Drafting of the manuscript: Strangfeld, Listing.
Critical revision of the manuscript for important intellectual content: Herzer, Liebhaber, Rockwitz, Richter, Zink.
Statistical analysis: Listing.
Obtained funding: Zink.
Study supervision: Zink.
Financial Disclosures: None reported.
Funding/Support: RABBIT has been supported by an unconditional joint grant from Essex pharma (since 2001), Wyeth pharma (since 2001), Amgen (since January 2003), Abbott (since September 2003), Hoffmann-La Roche (since January 2007), and Bristol-Myers Squibb (since July 2007).
Role of the Sponsors: All 6 funding companies received the manuscript 30 days prior to submission for the purposes of information. Under the terms of the RABBIT contract the investigators are free to publish all findings; in case the companies do not agree, they can comment on this in a footnote. The sponsors had no influence on design and conduct of the study; the collection or interpretation of the data; the development of the analysis plan; the preparation and conduct of the analysis; or the drafting, critical revision, or approval of the final manuscript.
Additional Contributions: We acknowledge the invaluable contributions of all participating consultant rheumatologists and would like to thank in particular those who enrolled at least 25 patients each: Winfried Demary, MD, Hildesheim; Andreas Krause, MD, Immanuel Hospital Berlin; Maria Stoyanova-Scholz, MD, Wedau Kliniken, Duisburg; Karin Babinsky, MD, Halle; Thilo Klopsch, MD, Neubrandenburg; Gerd-Rüdiger Burmester, MD, Charité University Medicine, Berlin; Arnold Bussmann, MD, Geilenkirchen; Hans Peter Tony, MD, Medizinische Poliklinik der Universität Würzburg; Katja Richter, MD, Universitätsklinikum Carl Gustav Carus Dresden; Brigitte Krummel-Lorenz, MD, Frankfurt/Main; Anett Grässler, MD, Pirna; Elke Wilden, MD, Köln; Michael Hammer, MD, St. Josef-Stift Sendenhorst; Edmund Edelmann, MD, Bad Aibling; Christina Eisterhues, MD, Braunschweig; Wolfgang Ochs, MD, Bayreuth; Thomas Karger, MD, Eduardus-Krankenhaus Köln-Deutz; Michael Bäuerle, MD, Universität Erlangen, Erlangen; Herbert Kellner, MD, München; Silke Zinke, MD, Berlin; Angela Gause, MD, Elmshorn; Lothar Meier, MD, Hofheim; Karl Alliger, MD, Zwiesel; Martin Bohl-Bühler, Brandenburg; Carsten Stille, MD, Hannover; Susanna Späthling-Mestekemper, MD, and Thomas Dexel, MD, München; Harald Tremel, MD, Hamburg; Stefan Schewe, MD, Medizinische Poliklinik der Ludwig-Maximilians-Universität München; Helmut Sörensen, MD, Krankenhaus Waldfriede Berlin; Florian Schuch, MD, Erlangen; Klaus Krüger, MD, München; Andreas Teipel, MD, Leverkusen; Kirsten Karberg, MD, Berlin; Gisela Maerker-Alzer, MD, and Dorothea Pick, MD, Holzweiler; Volker Petersen, MD, Hamburg; Kerstin Weiss, MD, Lichtenstein; Werner Liman, MD, Ev. Krankenhaus Hagen-Haspe; Kurt Gräfenstein, MD, Johanniter-Krankenhaus im Fläming, Treuenbrietzen; Jochen Walter, MD, Rendsburg; Werner A. Biewer, MD, Saarbrücken; Roland Haux, MD, Berlin; Wolfgang Gross, MD, Lübeck; Michael Zänker, MD, Evangelisches Freikirchliches Krankenhaus Eberswalde; Gerhard Fliedner, MD, Osnabrück; Thomas Grebe, MD, Ev. Krankenhaus Kredenbach; Karin Leumann, MD, Riesa; Jörg-Andres Rump, MD, Freiburg; Joachim Gutfleisch, MD, Biberbach; Michael Schwarz-Eywill, MD, Evangelisches Krankenhaus Oldenburg; Kathrin Fischer, MD, Greifswald; Monika Antons, MD, Köln. We also acknowledge the significant contributions to the conception of RABBIT of Rolf Rau, MD, and Matthias Schneider, MD, University of Duesseldorf, and Jörn Kekow, MD, University of Magdeburg, in their function as members of the advisory board. The work in the advisory board of RABBIT is honorary, without any financial compensation. We also recognize the substantial contribution of Christina Bungartz, Ulrike Kamenz, Franka Hierse, and Susanna Zernicke, all employees of the German Rheumatism Research Center, Berlin, in the study monitoring and support of the data analyses; none of these individuals received extra compensation for their contributions.