Just over 6 months ago a decision was made to reinstitute smallpox vaccination
for selected segments of the US population.1 This
decision to implement a pre-event smallpox vaccination program was based on
the concern that smallpox could be used as an agent of bioterrorism; however,
certain questions about the risk of smallpox vaccination in a 21st-century
setting arose.2,3 Among these
was the possibility that the current United States population might be more
vulnerable to serious adverse effects of the smallpox vaccine due to a relative
increase—compared with 3 to 4 decades ago—in conditions affecting
the immune system such as the use of immunosuppressive drugs and the presence
of human immunodeficiency virus infection in the community. A consequence
of this change in population profile could be an increased incidence of established
adverse events as well as the emergence of heretofore unrecognized adverse
events. At the same time that these issues were being raised, there was also
an appreciation that the immunization of a new generation of individuals provided
an opportunity to apply 21st-century technology to the study of vaccinia-induced
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 4
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.