To reduce the incidence of neural tube defects, the US Food and Drug Administration (FDA) mandated folic acid fortification of flour and other grains beginning in 1998.1 Subsequent studies showed an overall increase in mean folic acid levels among US residents.2,3 Within a few years of this mandate, a decrease in the incidence of neural tube defects was noted in newborns.4 However, longer-term benefits of folic acid fortification for disease prevention,5 including multiple cancers,6- 8 remain to be documented. Animal studies suggest that modest supplementation can reduce carcinogenesis. On the other hand, high doses of folic acid may speed cell division and increase tumor progression in preneoplastic lesions.9,10 Better understanding of time frame and dosage is key to balancing risk and benefits.
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 2
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.