Author Contributions: Dr Ravussin had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: DeLany, Larson-Meyer, Volaufova, Greenway, Deutsch, Williamson, Ravussin.
Acquisition of data: Heilbronn, de Jonge, Frisard, DeLany, Larson-Meyer, Nguyen, Martin, Most, Smith, Williamson, Ravussin.
Analysis and interpretation of data: Heilbronn, de Jonge, DeLany, Rood, Volaufova, Deutsch, Williamson, Ravussin.
Drafting of the manuscript: Heilbronn, Rood, Martin, Most, Deutsch, Williamson, Ravussin.
Critical revision of the manuscript for important intellectual content: de Jonge, Frisard, DeLany, Larson-Meyer, Nguyen, Martin, Volaufova, Greenway, Smith, Deutsch, Williamson, Ravussin.
Statistical analysis: Heilbronn, Volaufova, Ravussin.
Obtained funding: Williamson, Ravussin.
Administrative, technical, or material support: Heilbronn, de Jonge, DeLany, Rood, Nguyen, Martin, Greenway, Smith, Williamson, Ravussin.
Study supervision: Heilbronn, Frisard, Larson-Meyer, Most, Greenway, Deutsch, Williamson, Ravussin.
Financial Disclosures: None reported.
Funding/Support: This work was supported by research grant U01 AG20478 from the National Institutes of Health.
Role of the Sponsor: The funding agency had no role in the analysis or interpretation of the data or in the decision to submit the report for publication.
Other Members of the Pennington CALERIE Research Team: Steven Anton, PhD, Emily York-Crowe, MA, Catherine Champagne, PhD, Paula Geiselman, PhD, Michael Lefevre, PhD, Jennifer Howard, LDN, RD, Jana Ihrig, BSN, Brenda Dahmer, Anthony Alfonso, MS, Darlene Marquis, BS, Connie Murla, BS, Aimee Stewart, BS, Amanda Broussard, BS, and Vanessa Tarver, BS (all from Pennington Biomedical Research Center, Louisiana State University, Baton Rouge).
Acknowledgment: Our gratitude is extended to the excellent staffs of the Outpatient Clinic, Inpatient Clinic, Metabolic Kitchen, and Clinical Chemistry Laboratory. We also want to thank Claudia Van Skiver, LDN, RD (Ochsner Clinic, Baton Rouge, La) for developing the behavioral treatment manual and training the staff on how to use the HMR energy counting system. Our thanks also go to Health and Nutrition Technology, Carmel, Calif, for providing us with the HealthOne formula used in the study. Finally, our profound gratitude goes to all the volunteers who spent so much time participating in this very demanding research study.