Author Contributions: Dr Gong had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Cooper-DeHoff, Handberg, Pepine.
Acquisition of data: Cooper-DeHoff, Handberg, Pepine.
Analysis and interpretation of data: Cooper-DeHoff, Gong, Handberg, Bavry, Denardo, Bakris, Pepine.
Drafting of the manuscript: Cooper-DeHoff.
Critical revision of the manuscript for important intellectual content: Cooper-DeHoff, Gong, Handberg, Bavry, Denardo, Bakris, Pepine.
Statistical analysis: Gong.
Obtained funding: Pepine, Handberg.
Administrative, technical, or material support: Cooper-DeHoff, Gong, Handberg, Bavry, Denardo, Bakris, Pepine.
Study supervision: Pepine, Handberg, Cooper-DeHoff.
Financial Disclosures: Dr Cooper-DeHoff reported receiving research funding from Abbott Laboratories during the conduct of INVEST. Dr Handberg reported receiving grant support from National Heart, Lung, and Blood Institute (NHLBI), Abbott Laboratories, Fujisawa, Pfizer, GlaxoSmithKline, and educational grants from the Vascular Biology Working Group (AstraZeneca, Sanofi Aventis, Schering-Plough, Daiichi Sankyo Lilly, AtCor Medical, XOMA. Dr Bakris reported receiving grant and research support from the Juvenile Diabetes Research Foundation, GlaxoSmithKline, Forest Laboratories, and CVRx; reported also serving as a consultant for GlaxoSmithKline, Merck, Novartis, Boehringer-Ingelheim, Takeda, Abbott Laboratories, Walgreens, Bristol Meyer Squibb/Sanofi, Gilead, Forest Labs and CVRx, Fibrogen, Spherix, Johnson & Johnson, Daiichi Sankyo, and Mitsubishi. Dr Pepine reported receiving research grants from the NHLBI, Abbott Laboratories, Baxter, Pfizer, GlaxoSmithKline, and Bioheart Inc; serving as consultant for Abbott Laboratories, Forest Laboratories, Novartis/Cleveland Clinic, NicOx, Angloblast, Sanofi-Aventis, NHLBI, NIH, Medtelligence, and SLACK Inc; receiving unrestricted educational grants from AstraZeneca, AtCor Medical Inc, Daiichi Sankyo Inc, Eli Lilly, Pfizer Inc, Sanofi-Aventis, and Schering-Plough. Drs Gong, Bavry, and Denardo reported that they have no financial disclosures.
Funding/Support: INVEST was funded by a grant from Abbott Laboratories and the University of Florida Opportunity Fund. The present research is supported in part by grants K23HL086558 and UOIGM074492 from the National Institutes of Health (Dr Cooper-DeHoff).
Role of the Sponsors: Abbott Laboratories had no role in the design or conduct of the study, collection or analysis of the data, or preparation or approval of the manuscript.