Author Contributions: Drs Wang and Larson had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Cheng, Larson, Benjamin, Vasan, Wang.
Acquisition of data: Cheng, Benjamin, Vasan, Wang.
Analysis and interpretation of data: Cheng, Keyes, Larson, McCabe, Newton-Cheh, Levy, Benjamin, Vasan, Wang.
Drafting of the manuscript: Cheng, Vasan, Wang.
Critical revision of the manuscript for important intellectual content: Keyes, Larson, McCabe, Newton-Cheh, Levy, Benjamin.
Statistical analysis: Keyes, Larson, McCabe.
Obtained funding: Vasan, Wang.
Administrative, technical, or material support: Levy, Vasan, Wang.
Study supervision: Vasan, Wang.
Financial Disclosures: None reported.
Funding/Support: The Framingham Heart Study is funded by National Institutes of Health contract N01-HC-25195. Dr Vasan was supported in part by grant K24-HL-04334.
Role of the Sponsor: The National Heart, Lung, and Blood Institute (NHLBI) had no role in the design and conduct of the study; the collection, analysis, and interpretation of the data; or the drafting of the manuscript. The NHLBI reviews all manuscripts submitted for publication but had no role in the decision to publish this article.