Author Contributions: Isakova had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Isakova, Hsu, Leonard, Feldman, Wolf.
Acquisition of data: Anderson, Steigerwalt, He, Schwartz, Lo, Ojo, Sondheimer, Hsu, Leonard, Feldman, Wolf.
Analysis and interpretation of data: Isakova, H. Xie, Yang, D. Xie, Anderson, Scialla, Wahl, Gutierrez, Lash, Kusek, Feldman, Wolf.
Drafting of the manuscript: Isakova, Wolf.
Critical revision of the manuscript for important intellectual content: Isakova, H. Xie, Yang, D. Xie, Anderson, Scialla, Wahl, Gutierrez, Steigerwalt, He, Schwartz, Lo, Ojo, Sondheimer, Hsu, Lash, Leonard, Kusek, Feldman, Wolf.
Statistical analysis: Isakova, H. Xie, Yang, D. Xie, Anderson, Scialla, Wahl, Gutierrez, Lash, Feldman, Wolf.
Obtained funding: He, Hsu, Leonard, Wolf.
Administrative, technical, or material support: Lo, Ojo, Sondheimer, Hsu.
Study supervision: Hsu, Kusek, Wolf.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Wolf reported that he has served as a consultant or received honoraria from Abbott Laboratories, Amgen, Ardelyx, Baxter, Cytochroma, Genzyme, Lutipold, Novartis, Mitsubishi, and Shire. Dr Isakova reported that she has served as a consultant for and received honoraria from Shire. No other conflicts of interest were disclosed.
Funding/Support: This CRIC ancillary study was supported by National Institutes of Health grants R01DK081374 (Dr Wolf), K23DK087858 (Dr Isakova), and R01DK077128 (Dr Leonard). The CRIC Study is supported by cooperative agreement project grants 5U01DK060990, 5U01DK060984, 5U01DK06102, 5U01DK061021, 5U01DK061028, 5U01DK60980, 5U01DK060963, and 5U01DK060902 from the National Institute of Diabetes and Digestive and Kidney Diseases, and by grants UL1RR024134, UL1RR025005, M01RR16500, UL1RR024989, M01RR000042, UL1RR024986, UL1RR029879, RR05096, and UL1RR024131 from the National Institutes of Health.
Role of the Sponsors: The National Institutes of Health (NIH) contributed to the design, development and steering (Dr Kusek) of the Chronic Renal Insufficiency Cohort Study. For the current report, one NIH coauthor (Dr Kusek) contributed to the design and conduct of the study, analysis and interpretation of the data, and review and approval of the manuscript.