Author Contributions: Drs Reulen and Frobisher had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Reulen and Frobisher contributed equally to this article.
Study concept and design: Reulen, Winter, Jenkinson, Hawkins.
Acquisition of data: Reulen, Frobisher, Winter, Kelly, Lancashire, Stiller, Hawkins.
Analysis and interpretation of data: Reulen, Frobisher, Winter, Stiller, Prichard-Jones, Hawkins.
Drafting of the manuscript: Reulen, Frobisher, Hawkins.
Critical revision of the manuscript for important intellectual content: Reulen, Frobisher, Winter, Kelly, Lancashire, Stiller, Prichard-Jones, Jenkinson, Hawkins.
Statistical analysis: Reulen, Frobisher, Hawkins.
Obtained funding: Lancashire, Hawkins.
Administrative, technical, or material support: Winter, Kelly, Lancashire, Hawkins.
Study supervision: Hawkins.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.
The British Childhood Cancer Survivor Study Steering Group for study oversight (without compensation): Douglas Easton, PhD (chair), University of Cambridge; Michael Hawkins, DPhil, University of Birmingham; Helen Jenkinson, MD, Birmingham's Children's Hospital; Meriel Jenney, MD, Children's Hospital for Wales, Cardiff; Emma Lancashire, PhD, University of Birmingham; Kathryn Pritchard-Jones, MD, The Institute of Cancer Research, Surrey; Michael Stevens, MD, University of Bristol; Charles Stiller, Childhood Cancer Research Group, Oxford; Elaine Sugden, MD, Churchill Hospital, Oxford; Andrew Toogood, MD, University Hospital Birmingham; and Hamish Wallace, MD, Royal Hospital for Sick Children, Edinburgh.
Funding/Support: This work was supported by Cancer Research UK and Kay Kendall Leukaemia Fund. The Childhood Cancer Research Group receives funding from the Department of Health and the Scottish Ministers.
Role of the Sponsor: Cancer Research UK, Kay Kendall Leukaemia Fund, the Department of Health, and the Scottish Ministers had no involvement in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Disclaimer: The views expressed here are not necessarily those of Cancer Research UK, Kay Kendall Leukaemia Fund, the Department of Health, or the Scottish Ministers.
Previous Presentation: This study was presented in part at the 11th International Conference of Long-term Complications of Treatment of Children and Adolescents for Cancer, June 11-12, 2010; Williamsburg, Virginia.
Additional Contributions: The British Childhood Cancer Survivor Study (BCCSS) benefits from the contributions of the officers, centers, and individual members of the Children's Cancer and Leukemia Group, the Childhood Cancer Research Group, and the Regional Pediatric Cancer Registries. The BCCSS acknowledges the collaboration of the Office for National Statistics, the General Register Office for Scotland, the National Health Service Central Registers, the regional cancer registries, health authorities, and area health boards for providing general practitioner names and addresses and the general practitioners nationwide who facilitated direct contact with survivors. The BCCSS would not have been possible without the support of our 2 funders: Cancer Research UK and the Kay Kendall Leukaemia Fund, to whom we offer our profound thanks. We thank Trevor Cole, MD, of the West Midlands Regional Genetics Service, for his comments on earlier drafts of the manuscript and all BCCSS staff who have given many years of dedicated work to bring the BCCSS to fruition. The BCCSS staff and Dr Cole were not compensated in association with their contributions to this article.