Prophylactic vaccines have forever reduced the burden of disease in the United States and around the world.1 One of the critical keys to success for prophylactic vaccines was that scientists set their sights on high-burden infectious diseases—frequently with high incidence, and often with high rates of mortality and morbidity and minimally effective therapeutic options at the time vaccines were developed.
Now, in the midst of a golden era of continuing prophylactic vaccine successes,2 therapeutic vaccines for cancer are being developed. Currently available treatments with surgery, chemotherapy, and radiation therapy help about 2 of every 3 patients diagnosed with cancer survive for at least 5 years in the United States,3 but many of those patients experience treatment complications and morbidities that reduce their quality of life. Therapeutic vaccines that trigger individuals' targeted immune response against tumor-specific antigens and tumor-associated antigens may offer patients with cancer dual benefits of improved survival and reduced adverse effects.
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Quadrants are designated based on median values of the axes (incidence = 43 050; 5-year survival = 65.2%). Five-year survival data are based on 2001-20073; incidence data are estimated for 2010.6 Not shown are Kaposi sarcoma and mesothelioma, for which estimates of mortality in 2010 were not available.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 1
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.