Author Contributions: Dr Conen had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Conen, Albert.
Acquisition of data: Conen, Chae, Tedrow, Everett, Buring, Albert.
Analysis and interpretation of data: Conen, Chae, Glynn, Tedrow, Everett, Buring, Albert.
Drafting of the manuscript: Conen, Albert.
Critical revision of the manuscript for important intellectual content: Conen, Chae, Glynn, Tedrow, Everett, Buring, Albert.
Statistical analysis: Conen, Glynn.
Obtained funding: Buring, Albert.
Administrative, technical, or material support: Everett.
Study supervision: Albert.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Conen reports receiving research grants from Boehringer Ingelheim, Sanofi-Aventis, Novartis, the Swiss National Science Foundation (PP00P3_133681), and the University of Basel. Dr Glynn reports receiving an honorarium for an invited talk from Merck and research grants for data monitoring and analysis of clinical trials from AstraZeneca. Dr Tedrow reports receiving consultancy fees from St Jude Medical, research grants from Biosense Webster, and grants from Biosense Webster, St Jude Medical, and Medtronic Inc to support the fellows' program at Brigham and Women's Hospital that she directs. Dr Albert reports receiving grant and administrative support from the National Institutes of Health/National Heart, Lung, and Blood Institute (NHLBI), American Heart Association, Siemens Healthcare Diagnostics, and St Jude Medical, consultancy fees from Novartis, and speaker honorarium from Boston Scientific and St Jude Medical. No other conflict of interest disclosures were reported.
Funding/Support: This study was supported by grant HL-093613 from the NHLBI to Dr Albert. The WHS was supported by grants HL-043851, HL-080467, and HL-099355 from the NHLBI and grant CA-047988 from the National Cancer Institute.
Role of the Sponsors: The funding organizations had no role in the design and conduct of the study; in the collection, management, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.