Author Contributions: Dr Schaan had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Leitao, Gross, Ribeiro, Schaan.
Acquisition of data: Umpierre, Ribeiro, Zucatti, Schaan.
Analysis and interpretation of data: Umpierre, Ribeiro, Kramer, Leitao, Azevedo, Gross, Ribeiro, Schaan.
Drafting of the manuscript: Umpierre, Ribeiro, Kramer, Leitao, Zucatti, Ribeiro, Schaan.
Critical revision of the manuscript for important intellectual content: Leitao, Azevedo, Gross, Ribeiro, Schaan.
Statistical analysis: Umpierre, Ribeiro, Kramer.
Obtained funding: Leitao, Azevedo, Gross, Schaan.
Administrative, technical, or material support: Zucatti, Azevedo.
Study supervision: Azevedo, Ribeiro, Schaan.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Gross reports having attended advisory board meetings, received research support, and undertaking clinical trials sponsored by Bristol-Myers Squibb; and delivered continuing medical educational programs sponsored by Bristol-Myers Squibb, GlaxoSmithKline, and Merck Sharp & Dohme. Dr Ribeiro reports having received consulting fees from Merck Sharp & Dohme and Servier; lecturing fees from Abbott, Aventis, Bioassist, Merck Sharp & Dohme, and Servier; and grant support from Boehringer Ingelheim, Bristol-Myers Squibb, Merck Sharp & Dohme, and Servier. The other authors reported no disclosures.
Funding/Support: This study was partially supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) grant 576627/2008-9 and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) PNPD 03021/09-2.
Role of the Sponsor: The sponsors of the study had no role in the study design, data collection, data analysis, data interpretation, or writing of the report.