Author Contributions: Drs Ding and Larson had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Welch, Westervelt, Ding, Larson, Klco, Watson, Tomasson, Link, Graubert, DiPersio, Mardis, Ley, Wilson.
Acquisition of data: Klco, Kulkarni, Fulton, Veizer, Vickery, Heath, Watson, Wilson.
Analysis and interpretation of data: Welch, Westervelt, Ding, Larson, Klco, Kulkarni, Wallis, Chen, Payton, Fulton, Veizer, Schmidt, Vickery, Mardis, Ley, Wilson.
Drafting of the manuscript: Welch, Westervelt, Ley.
Critical revision of the manuscript for important intellectual content: Welch, Westervelt, Ding, Larson, Klco, Kulkarni, Wallis, Chen, Payton, Fulton, Veizer, Schmidt, Vickery, Heath, Watson, Tomasson, Link, Graubert, DiPersio, Mardis, Ley, Wilson.
Statistical analysis: Ding, Larson, Wallis, Chen, Schmidt, Vickery.
Obtained funding: Ley, Wilson.
Administrative, technical, or material support: Welch, Klco, Fulton, Vickery, Heath, Watson, Graubert, Ley, Wilson.
Sequence analysis: Ding, Larson, Wallis, Chen, Schmidt, Vickery.
Drs Welch and Westervelt contributed equally to this work.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Westervelt reported receiving lecture fees from Celgene and Novartis; Dr DiPersio reported receiving consulting and lecture fees from Genzyme. No other authors reported disclosures.
Funding/Support: This study was supported by the Washington University Cancer Genome Initiative, by National Institutes of Health (NIH) grant PO1 CA101937, by Barnes-Jewish Hospital Foundation grant 00335-0505-02 (Dr Ley), and by NIH grant U54 HG003079 (Dr Wilson). Dr Welch is a fellow of the Leukemia Lymphoma Society.
Role of the Sponsor: The funding organizations had no role in design and conduct of the study; the collection, management, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
Additional Contributions: We thank the Washington University Cancer Genomics Initiative for its support and Charles W. Caldwell, MD, PhD, and Carl Freter, MD (both at University of Missouri-Columbia School of Medicine), for referring the patient and for collecting, storing, and contributing the cryopreserved bone marrow cells used for this study. Neither of these individuals received compensation for their contributions.