Published Online: April 11, 2011. doi:10.1001/jama.2011.468
Author Contributions: Drs Peralta, Shlipak, Muntner, and Judd had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Peralta, Shlipak, Cushman, Muntner, Warnock.
Acquisition of data: Zhang.
Analysis and interpretation of data: Peralta, Shlipak, Judd, Cushman, McClellan, Zakai, Safford, Muntner, Warnock.
Drafting of the manuscript: Peralta.
Critical revision of the manuscript for important intellectual content: Peralta, Shlipak, Judd, Cushman, McClellan, Zakai, Safford, Zhang, Muntner, Warnock.
Statistical analysis: Judd.
Obtained funding: Peralta, Safford, Warnock.
Study supervision: Shlipak, Cushman, Muntner.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Warnock reported that he is a consultant for Amgen Corp and has received research support from Amgen. Dr Cushman reported receiving research support from Amgen. Dr McClellen reported receiving research support from Amgen. Otherwise, no other conflicts of interest were reported.
Funding/Support: This research project is supported by cooperative agreement U01 NS041588 from the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Services. Additional funding was provided by an investigator-initiated grant-in-aid from Amgen Corp. Dr Peralta is funded by the National Institutes of Diabetes and Digestive and Kidney Diseases grant 1K23SK082793-01 and a Robert Wood Johnson Harold Amos award. Dr Shlipak is funded by grants R01AG034853 (PI), R01DK066488 (PI), R01HL085757 (Co-Investigator), R01DK078124 (Co-Investigator), and R21HL091217 (Co-Investigator) and by an American Heart Association Established Investigator Award (0640012N; PI).
Role of the Sponsor: Amgen had no role in the design and conduct of the study, the collection, management, analysis, and interpretation of the data, or the preparation or approval of the manuscript.
Additional Contributions: We thank the staff members at the USRDS Coordinating Center for their assistance with the linkage to the USRDS under a data-use agreement between the USRDS and the University of Alabama at Birmingham. The manuscript was sent to Amgen for review prior to submission for publication. The authors thank the investigators, staff, and participants of the REGARDS study for their valuable contributions. A full list of participating REGARDS investigators and institutions can be found at http://www.regardsstudy.org.