Author Contributions: Dr Wald had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Tronstein, Corey, Wald.
Acquisition of data: Huang, Warren, Corey, Wald.
Analysis and interpretation of data: Tronstein, Johnston, Selke, Magaret, Corey, Wald.
Drafting of the manuscript: Tronstein, Johnston, Selke, Wald.
Critical revision of the manuscript for important intellectual content: Tronstein, Johnston, Huang, Magaret, Warren, Corey, Wald.
Statistical analysis: Tronstein, Johnston, Selke, Magaret, Corey, Wald.
Obtained funding: Corey, Wald.
Administrative, technical, or material support: Huang, Corey, Wald.
Study supervision: Johnston, Corey, Wald.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Ms Tronstein, Ms Selke, and Dr Huang all reported receiving research support from National Institutes of Health (NIH) P01AI030731. Dr Johnston reported receiving research support from NIH K23AI079394 and having received funding from GlaxoSmithKline and AiCuris. Dr Magaret reported receiving funding from NIH (P01AI030731 and K24AI071113) and consulting for Immune Design. Ms Warren reported having received research support from AiCuris and having served on the GlaxoSmithKline speakers' bureau. Dr Corey reported receiving research support from NIH (P01AI030731, R37AI042528) and consulting for AiCuris; he reports being listed as a coinventor on several patents describing antigens and epitopes to which T-cell responses to HSV-2 are directed (these proteins have the potential to be used in candidate vaccines against HSV), and he has received fees for serving as the head of the scientific advisory board of Immune Design, including equity shares that are less than 1% ownership. Dr Wald reported receiving research support from NIH (K24AI071113, P01AI030731) and GlaxoSmithKline and consulting for AiCuris.
Funding/Support: This work was supported by NIH grants PO1A1030731 and K24 AI 071113.
Role of the Sponsor: The NIH has had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Additional Contributions: We are indebted to the study participants and the study clinicians.