Author Contributions: Mr Nunn had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Lienhardt, Kim, Jindani, Enarson, Nunn.
Acquisition of data: Lienhardt, Cook, Burgos, Yorke-Edwards, Rigouts, Anyo, Enarson.
Analysis and interpretation of data: Lienhardt, Burgos, Rigouts, Enarson, Nunn.
Drafting of the manuscript: Lienhardt, Enarson, Nunn.
Critical revision of the manuscript for important intellectual content: Lienhardt, Cook, Burgos, Yorke-Edwards, Rigouts, Anyo, Kim, Jindani, Enarson, Nunn.
Statistical analysis: Nunn.
Obtained funding: Jindani, Enarson.
Administrative, technical, or material support: Lienhardt, Cook, Yorke-Edwards, Rigouts, Anyo, Kim, Jindani, Enarson.
Study supervision: Lienhardt, Cook, Burgos, Rigouts, Anyo, Kim, Jindani, Enarson.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.
Funding/Support: This study was supported by United States Agency for International Development (USAID) cooperative agreement GHS-A-00-03-00045-00.
Role of the Sponsor: USAID had no role in the design and conduct of the study; the collection, analysis, and interpretation of the data; or the preparation, review, or approval of the manuscript.
Study C Trial Group Members:Algiers, Algeria: Service de Pneumo-phtisiologie de Matiben, CHU de Béni-Messous (investigators: Zidouni Noureddine, Pierre Chaulet, Djillali Larbaoui; person in charge: Dalila Mekideche; microbiologists: Djamel Yala, Fadila Boulahbal); Cali, Colombia: Centro Internacional de Entrenamiento e Investigaciones Médicas–CIDEIM (investigators: Hildegard Piñeros, Beatriz Ferro; persons in charge: Hildegard Piñeros, Cristian Rojas, Margarita Chamorro, Sonia Villegas; microbiologists: Beatriz E. Ferro, Edna Hernández); Conakry, Guinea: Service de Pneumo-Phtisiologie (investigators: Boubacar Bah, Barry Mamadou Dian, Dumou Bah-Sow; persons in charge: Boubacar Bah, Mariama Tata Barry; microbiologist: Barry Mamadou Dian); Hanoi, Vietnam: National TB Programme, National Hospital of TB and Respiratory Diseases–NHTRD: (investigators: Dinh Ngoc Sy, Luu Thi Lien; persons in charge: Nguyen Thi Thuy Ha, Pham Huu Thuong; microbiologist: Nguyen Van Hung); Ho Chi Minh City, Vietnam: National TB Programme, National Hospital of TB and Respiratory Diseases–NHTRD (investigators: Tran Ngoc Buu, Hoang Thi Quy; persons in charge: Tran Ngoc Buu, Phan Thanh Liem; microbiologist: Nguyen Thi Ngoc Lan); Kathmandu, Nepal: German Nepal Tuberculosis Project (GENETUP)/Nepal Anti-Tuberculosis Association–NATA (investigator: Bhabana Shrestha; person in charge: Sanu Kaji Tandukar; microbiologist: Bhagwan Maharjan); Nepalgunj, Nepal: International Fellowship TB/Leprosy Project (investigator: Keshava Raj Sharma; persons in charge: Keshava Raj Sharma, Hikmat Bahadur Khadha; microbiologist: Bhagwan Maharjan); Lima, Peru: Servicio de Enfermedades Infecciosas y Tropicales, Hospital Nacional Dos de Mayo, Parque Historia de la Medicina Peruana (investigator: Eduardo Ticona; persons in charge: Milagros Chumpitaz, Rosmery Gutierrez, Angie Roldan, Jackeline Aspajo; microbiologist: Luz Maria Huaroto; Manhiça, Mozambique: Centro de Investigaçao en Saúde de Manhiça (investigators: Mateu Espasa Soley, Jose Muñoz, Julian Gonzalez Martin; persons in charge: Issufo Juma Aly, Maria Catarina Marcelino, Sonia Machevo; microbiologist: Luis Morais); Mwanza, Tanzania: National Institute for Medical Research, NIMR/AMREF/LSHTM Collaborative Projects (investigator: John Changalucha; persons in charge: Manset Temu, Stanslaus Mayunga; microbiologist: Apolinary Mgomela); Santa Cruz, Bolivia: Responsable del Programa Nacional de Control de la Tuberculosis (investigators: Ilona Patino Wastermann, Dra Mirtha Camacho; persons in charge: Ilona Patino Wastermann, Rosario Ruiz, Guzmán Segundo; microbiologist: Ingrid Bozo). Technical Assistance:Microbiology: Mourad Gumusboga (Institute of Tropical Medicine, Antwerp, Belgium), Dhanida Rienthong (National Tuberculosis Reference Laboratory, Bangkok, Thailand), Gabriella Torrea and Armand van Deun (Institute of Tropical Medicine, Antwerp, Belgium); Data Management: Laura Belton, Natalie Young (Medical Research Council Clinical Trials Unit, London, United Kingdom); Administration: Thuy Duong, Martine Fontayne, Ludmilla Hermite, Laetitia Ruffle (International Union Against Tuberculosis and Lung Disease, Paris, France).
Disclaimer: The contents of this article are the responsibility of the authors and do not necessarily reflect the views of USAID or the US government.
Additional Contributions: We are grateful to all of the patients who voluntarily contributed to the trial and to all staff in the various sites who contributed wholeheartedly to its success.