Like many patients, pioneering genetic researcher James Watson had a hard time tolerating the β-blockers he was taking to control hypertension. “They put me to sleep,” he said during a February symposium at the National Institutes of Health (NIH). But unlike most patients, Watson was able to deduce the cause of this adverse effect by examining his genes.
One of the first human beings to undergo whole-genome sequencing(Wheeler DA et al. Nature. 2008;45:872-876), Watson found that he carried a certain genetic variant that made him a slow metabolizer of the drug. So he and his physician reduced his dose, and he is now able to control his blood pressure without such adverse effects.
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Graphic Jump Location
Scientists are hoping to build on the scaffolding of information gleaned from the Human Genome Project to develop improved clinical interventions for patients.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 1
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
All results at
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.