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Letters |

Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome

Jeffrey L. Jackson, MD; Jeffrey M. Cohen; Jordan Dimitrakoff, MD, PhD
JAMA. 2011;305(13):1298-1299. doi:10.1001/jama.2011.399.
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To the Editor: Although the direct meta-analysis methods that Dr Anothaisintawee and colleagues used in their review of the management of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)1 are mostly appropriate, we are concerned about the alternation between a random-effects and a fixed-effects model. In meta-analysis theory, when the heterogeneity of the studies is sufficiently low, the 2 models should produce the same result.2 However, if there is a significant difference between the results using fixed- and random-effects models, then a random-effects model should be used because it is more conservative. The tests for heterogeneity are notoriously insensitive.2


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April 6, 2011
Ammarin Thakkinstian, PhD; John Attia, MD, PhD, FRCPC, FRACP
JAMA. 2011;305(13):1298-1299. doi:10.1001/jama.2011.400.
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