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ARTICLE |

GLIOMA RETINÆ WITH REPORT OF FIVE CASES.

CHRISTIAN R. HOLMES, M.D.
JAMA. 1903;XL(13):820-828. doi:10.1001/jama.1903.92490130004001b.
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Glioma is a disease limited to childhood, and we may consider it the only true neoplasm developing in the retina. Its synonyms are: "Neuro-epithelioma" (Wintersteiner), "gliosarcoma" (Virchow), "glio-angio-sarcoma" and "tubular gliosarcoma" (De Gama Pinto).

H. Knapp, in 1867, appears to have been the first to give an accurate and thoroughly scientific description of this class of tumors. In 1868 appeared Hirschberg's classical work on this subject, with a report of 77 cases collected from different sources. Virchow believed the cells of this class of tumors to be derived from the supporting fibers of the retina (the glia), and hence gave it the name of glioma retinæ.

Iwanhoff, in 1869, described the structure of the glioma as follows: "The larger nodules are always very vascular, with a characteristic arrangement of the cells which are concentrically grouped around the blood vessels. On section the whole nodule appears to consist of closely arranged

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