0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

THE ADMINISTRATION OF CALCIUM SALTS IN NEPHROLITHIASIS DUE TO URIC ACID CALCULI.

ALFRED C. CROFTAN, M.D.
JAMA. 1903;XL(13):818-820. doi:10.1001/jama.1903.92490130002001a.
Text Size: A A A
Published online

THE UNDERLYING FACTS AND PRINCIPLES.  Phosphoric acid forms three salts with sodium, as follows :H3PO4, phosphoric acid.NaH2PO4, mono-sodium-phosphate.Na2HPO4, di-sodium-phosphate.Na3PO4, tri-sodium-phosphate.The mono- and the di-sodium phosphate normally occur in the urine. Uric acid is readily soluble in di-sodium phosphate, but it is not soluble in mono-sodium phosphate. The addition, in fact, of mono-sodium phosphate to a solution of uric acid in di-sodium phosphate will cause the precipitation of the uric acid.It is clear, therefore, that the solubility of uric acid in the urine is enhanced by the presence of di-sodium phosphate and that the tendency to the formation of uric acid concretions increases in proportion to the amount of mono-sodium phosphate that is excreted through the kidneys.It is also clear that any endeavor directed toward preventing the precipitation of uric acid in the urinary passages must be concerned with increasing the amount of

Topics

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();