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JAMA. 1890;XIV(18):658-659. doi:10.1001/jama.1890.02410180030009.
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Experiments demonstrating that Physical Fatigue is a powerful factor in the Production of Infectious Diseases—The Etiology of Asthenopia— Treatment of Endometritis by the Curettage of the Uterus—On Spontaneous Fracture in Tabetic Subjects—A Formula for an Antiseptic Paper.

In a note by Drs. Charrin and Roger published in the Revue Sciéntifique, the authors endeavored to afford experimental confirmation of the generally received view that physical fatigue is a powerful factor in the production of infectious disease. They subjected a number of white rats to severe exercise (running in a rotating cage) for four consecutive days, at seven hours each day. Eight of these tired out animals were then inoculated with attenuated anthrax virus, four animals in a normal condition of health being inoculated with the same virus at the same time, in order to serve as a standard of comparison. The result was, that seven of the


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