In the United States, national influenza vaccine recommendations have
typically been based on the prevention of complications and death among high-risk
persons. More recent is the increasing awareness that above and beyond the
more severe individual medical consequences of influenza, enormous societal
economic costs are associated with disruptions due to school and work absences
and days of illness. In this issue of THE JOURNAL, Nichol et al1
report that use of a live, attenuated influenza virus (LAIV) vaccine, administered
by intranasal spray to healthy, working adults (a group without a routine
recommendation to receive influenza vaccine), was followed in the subsequent
influenza epidemic season by a significant reduction in severe febrile illness,
days lost from work, health care visits, and the medication use that accompanies
these illnesses. Are these findings important? From an individual, medical,
and public health point of view, the answer is clearly yes. Reductions in
febrile illnesses, defined in various ways, ranged from approximately 13%
to 27%, reductions in work days lost from 18% to 28%, and reductions in health
care visits from 25% to 41%.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 11
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Users' Guides to the Medical Literature
The Rational Clinical Examination
Make the Diagnosis: Influenza
All results at
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.