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Analgesic Nephritis

Francis X. Fellers, MD; John Craig, MD
JAMA. 1963;186(6):610. doi:10.1001/jama.1963.03710060096023.
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To the Editor:  —We have read with interest the articles on analgesic nephritis by Reynolds and Edmondson and by Harrow and his associates in the May 11 issue of The Journal (184:435, 445).With the young albino rat as the experimental animal, we have been able to reproduce the characteristic lesion of renal papillary necrosis and renal tubular acidosis following the administration of salicylate or salicylate and acetazolamide sodium. These lesions occur with serum levels of salicylate (20-70 mg/100 ml) comparable to those obtainable in humans with the described oral dosage of 100 mg/kg by weight per day, which, in the face of the described severe renal impairment, were most likely cumulative levels. Although bacterial cultures of the urine or kidney tissues were not made in these animals, microscopic studies of these tissues involved failed to show an inflammatory response or the presence of bacteria in the kidney lesions


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