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The Responses of Children to Combined Measles-Poliomyelitis Vaccine

Joel Warren, PhD; Harry A. Feldman, MD; Domenic Iezzoni, MD; Vincent A. Fulginiti, MD; Thomas Conway, MD; Mary J. Gallian, AB
JAMA. 1963;186(6):533-536. doi:10.1001/jama.1963.03710060019004.
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Vaccine combining inactivated, concentrated measles and poliovirus antigens was prepared and administered to children in 3 doses of 0.5 ml each, 1 month apart. The neutralizing antibody responses to both antigens were determined in a group of 133 persons. The combination vaccine produced as high a percentage and titer of seroconversions as did the individual antigens alone, appeared to be stable for prolonged periods, and caused only minimal reactions upon injection. Although positive seroconversions were less in infants under 4 months of age, combined measles and polio vaccines should be considered for augmenting diphtheria-pertussis-tetanus vaccine to confer basic primary sensitization in young children.

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